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How effective is taxol Is there any other alternative What is the chemical structure of taxol What the iupac name for taxol
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Taxol is effective in the treatment of metastatic breast cancer because it targets the the mitotic spindle and the drug promotes polymerization and stabilization of tubulins to microtubulins.
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Yes there is!! Taxotere is another alternative for taxol and is more effective in the treatment of metastatic breast cancer with fewer side effect Also taxotere is more soluble than taxol.
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2α,4α,5β,7β,10β,13α)-4,10-bis(acetyloxy)- 13-{[(2R,3S)- 3-(benzoylamino)-2-hydroxy-3- phenylpropanoyl]oxy}- 1,7-dihydroxy-9-oxo- 5,20-epoxytax-11-en-2-yl benzoate
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George AO, Pascal VP, Hayley M and Susan BH: Mechanism of taxol resistance to microtubules. Oncogene 2003:22:7280-7295. 2nd November, 2012. Ringel I, Horwitz SB. Studies with RP 56976 (Taxotere ® ): a semisynthetic analogue of Taxol. J Natl Cancer Inst. 1991; 83:288-291. 2nd November, 2012
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