1. Gut And Psychology Syndrome Gut And Physiology Syndrome
The 1st WAPF UK conference
Dr Natasha Campbell-McBride MD 1

2. All diseases begin in the gut
All diseases begin in the gut! Hippocrates, BC Gut And Psychology / Gut And Physiology Syndrome
GAP Syndrome establishes a connection between the state of the gut and the health of the rest of the body

3. Roles of Gut Flora Protection from Invaders
Health and Integrity of the Gut
Appropriate Digestion and Absorption
Vitamin Production
Detoxification
Immune System Modulation

4. What can damage gut flora
Antibiotics
Steroids, The Pill
Other Drugs
Stress
Poor Diet
Infections
Disease
Bottle Feeding
Old Age
Pollution
Radiation
Alcohol
Toxic Chemicals
Dental Work

5. A Typical Scenario Mother with gut dysbiosis
The baby does not develop normal gut flora
Immune system compromised
Ear infections, antibiotics
Chest infections, antibiotics
Further damage to gut flora & immune system
Vaccinations
Usual weaning diet
Gut dysbiosis leads to damaged gut wall
Toxins, microbes, undigested foods enter the body
Autoimmunity joins in 5

9. DAMAGED GUT WALL Lack of protection by beneficial gut flora
Attack by pathogenic microbes & toxins
Enterocytes degenerate, tight junctions open
Foods absorb partially digested leading to food allergies & intolerances
Damaged gut lets toxins & microbes through into the blood steam
General toxicity in the body
Immune system reacts adding autoimmunity

10. Cleaning the flow from the gut Water soluble nutrients & toxins
Stage 1: through the gut wall into the blood steam
Stage 2: liver
Stage 3: lungs
Fat soluble nutrients & toxins
Stage 1: through the gut wall into lymph
Stage 2: lungs

11. Liver Greatly increased toxic flow from the gut Blocked detox pathways
Toxins by-pass filtering & go into the blood stream
From the environment: heavy metals, phenols, petro-chemicals, glue adhesives, agricultural chemicals, personal care & cleaning products, plasticisers, etc, etc
By-products of body’s own metabolism
All liver functions suffer

12. Lungs
Toxins, undigested foods, microbes eliminate through phagocytes & “mucociliary escalator”
Toxic gases escape
Damage to bronchi
Bronchospasm (wheeze) - a protective mechanism for healing bronchi
Anti-asthma drugs stop this mechanism leading to long-term lung damage
D Freed, J Mansfield. Asthma: What we do and why we do it. JNutr&EnvirMed, June 2008,17(2):97-110

13. Gut and Physiology Syndrome: Asthma
Used to be a benign condition (no asthma mortality) until anti-asthma drugs invented in s
Now a deadly disease
Anti-asthma drugs do not allow the lungs to eliminate toxins and heal the damage
Toxins go elsewhere in the body, causing damage
Fatal food allergies are associated with “well- controlled” asthma
Committee on Toxicity of Chemicals in Food. CTCFCPE; 2007, p.25, Crown Copyright

14. Gut and Physiology Syndrome
Elimination of toxins & undigested food
through lungs: asthma, other chronic lung conditions
through skin: eczema, other skin problems
through urine: chronic cystitis, bed wetting, thrush
through mucous membranes: sinusitis, post- nasal drip, rhinitis, gingivitis, vaginitis, diarrhoea/constipation, etc – all chronic

15. Gut and Physiology Syndrome Autoimmunity
Caused by absorption of protein and peptide complexes through damaged gut wall
Immune system produces antibodies, which then attack body’s own tissues
In type 1 diabetes pancreatic cells are attacked
In celiac disease small intestine is attacked
In MS, autism & other neurological problems nervous system is attacked
Always more than one tissue is attacked

16. Gut And Physiology Syndrome
Autoimmunity: multiple sclerosis, rheumatoid arthritis, diabetes type one, celiac disease, osteoarthritis, lupus, etc
Arthritis of any kind
ME, fybromialgia, chronic fatigue
Allergies
Migraines & other headaches
Chronic cystitis
Skin problems: psoriasis, eczema, etc

17. BLOOD - BRAIN BARRIER Very selective in letting things through
Tight junctions & zonulin
Microbial toxins and autoimmune attack
Damaged blood – brain barrier
Toxins, microbes & antibodies get through
Impaired brain function leads to impaired learning, behaviour, social skills & perception
Epileptic seizures

18. Gut And Psychology Syndrome Child Adult
SUBSTANCE ABUSE
DEPRESSION
OBSESSIVE- COMPULSIVE
MANIC- DEPRESSIVE
SCHIZOPHRENIA
AUTISM
ADHD/ADD
DYSLEXIA
DYSPRAXIA
LEARNING, BEHAVIOURAL, SOCIAL PROBLEMS

19. Epilepsy in children 1% of population under the age of 20
50% of children with mental problems
70% - no cause is apparent
In vast majority of cases childhood epilepsy
is due to toxicity coming from the gut
The treatment needs to concentrate
on the gut health

20. GAPS Nutritional Protocol
GAPS Diet
An Effective Probiotic
Address Nutritional Deficiencies
Detoxification 20