1. NIH/NASA Meeting on Space-Related Health Research Henry Rodriguez, Ph.D., M.B.A. Director, Clinical Proteomic Technologies Initiative National Cancer Institute December 8, 2006

2. Technology Benefits Bio-Technology Benefits to NASA Technology Benefits to NCI  Miniaturized biochemical analytic laboratories  Bio-Astronautics and Human Exploration  Fabrication of ultra rugged materials and structures  Early detection  Accurate diagnosis  Prevention and improved therapies

3. Fundamental Technologies in Biomolecular Sensors (NCI-NASA)  Workshop (June 1999) on Sensors for Bio-Molecular Signatures – Richard Klausner, Director NCI; Daniel Goldin, NASA Administrator – April 2000 MOU, Oct. 2000 launched  Total 6 awards, $13.6M over 4 yrs. – Launching companies & Building foundation for NCI Alliance for Nanotechnology in Cancer A. Peptide Functionalized Nanoparticles (Alnis Biosciences Inc., collaboration with UNC Center of Cancer Nanotechnology Excellence) B. Ultra-bright Near Infrared Fluorophores (possible synergy with Emory and MIT/Harvard Centers of Cancer Nanotechnology Excellence) C. Molecular Beacons (PI became co-PI of MIT/Harvard Center of Cancer Nanotechnology Excellence) Nanogel (carbohydrate or PEG nanoparticle – targeted drug delivery tool) A B C Molecular Beacons (enabling live detection of gene expression) Ultra-bright contrast agent (deep tissue imaging, > 1 cm)

4. Object Oriented Data Technology (NCI-NASA/JPL)  OODT’s architecture originally developed for NASA’s planetary data system (PDS) project by JPL – Open source & Based on open standards: Java, XML, Web Services – Distributed network that is secure and confidential  EDRN’s Virtual Specimen distributed query system (ERNE) is based on NASA’s OODT – Existing sites specimen databases maintained locally – Uses EDRN Common Data Elements (CDEs)  OODT Framework includes: – Name Server; Query Server; Archive Server; Profile Server; Product Server; Server Manager

5. Nanowire arrays for early detection (NCI/NASA-Goddard/U. Maryland)  Controlled on-chip synthesis (SiNWs and carbon nanotubes)  Surface mod. readily achieved for affinity-capture material  Ultra-sensitive and fast sensors for electrical, real-time and label-free detection sensing of chemical or biological species (amplicon - femtomolar)  Nucleic acid sequence detection, protein marker detection, and single viral particle detection Nanomedicine (2006) 1(1), 51-65 Nature Protocols (2006) 1(4), 1711-1724