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SOL Genomics Network Formed in 2003 to answer two questions: – How can a common set of genes give rise to such a wide range of morphologically and ecologically.

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Presentation on theme: "SOL Genomics Network Formed in 2003 to answer two questions: – How can a common set of genes give rise to such a wide range of morphologically and ecologically."— Presentation transcript:

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2 SOL Genomics Network Formed in 2003 to answer two questions: – How can a common set of genes give rise to such a wide range of morphologically and ecologically distinct organisms that occupy our planet? – How can a deeper understanding of the genetic basis of plant diversity be harnessed to better meet the needs of society in an environmentally- friendly and sustainable manner?

3 Lynn Bohs More than 3,000 Solanaceae species world-wide. Major evolutionary progress in South America unaltered by ice-ages and fueled by extreme climates.

4 2n=2x=24 950 Mb 2n=2x=24 3000 Mb 2n=4x=24 1800 Mb 2n=2x=24 1300 Mb 2n=2x= 22 ca. 1000 Mb

5 SOL Tomato Sequencing Genome size of 950 Mb. ~35,000 genes. 25% DNA lies in gene-dense euchromatin regions. Anchor BACs to genetic map (S. esculentum x S. pennellii F2) then choose new BACs based on sequenced ends. Verify physical location by FISH.

6 Comparable Maps Arabidopsis: – Arabidopsis COSII Eggplant: – Eggplant-LXM 2002 Pepper: – Pepper-FA03 – Pepper-AC99 Potato: – Potato-TXB 1992 Tobacco: – Tobacco SSR 2007 Tomato: – Tomato FISH map – Tomato-EXPIMP 2001 – Tomato-EXHIR 1997 – Tomato-EXPIMP 2008 – Tomato-EXPEN 1992 – Tomato-EXPEN 2000 – Tomato IL map (2) – Tomato physical map – Tomato FPC map – Tomato AGP map

7 123456789101112 euchromatin heterochromatin AT-rich satellite DNA Short arm Centromere Long arm 2426 191120271716101311 T=220 Mb* USA Korea China UK Chrom. USA The Netherlands France USA Spain USA Italy * Euchromatin portion

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10 The 10 missions of SOL 1) Sequence the reference tomato genome using BAC minimal tiling paths. 2)Develop deep EST databases and shotgun genomic sequences for other Solanaceae crops as well as SNP analysis of diverse germplasm. 3)Construct COS maps and interspecific introgression resources for all SOL crops 4)Establish a saturation set of mutagenesis lines and cloned gene specific tags (GST). 5)Construct a comprehensive phylogenetic and geographical distributional information network. 6)Apply transcription, proteomic & metabolic profiling to explore chemical and developmental evolution. 7)Apply non-destructive ‘Real Time’ physiology and phenotyping. 8)Improve the efficiency of plant breeding -- especially through use of natural diversity. 9)Educate the public about the value of biodiversity, domestication and plant improvement. 10)Develop an international bioinformatics platform which will facilitate a systems approach to SOL research.


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