1.  Hemochromatosis  Alzheimer's  Constant company  A global, evolutionary Macarena  It’s not only good for X-Men  DNA is history o Somewhere in your genetic code is the tale of every plague, every predator, every parasite, and every planetary upheaval your ancestors mangled to survive

2.  Hemochromatosis is inherited—and the gene for it is very common in certain populations  Iron Locking- Vivkings- founder’s effect  Bubonic plague: 1/3 to ½= 25 million people  People with Hemochromatosis are less susceptible?  Increase in European populations every time the disease resurfaced over the ensuing three hundred years  Evolutionary bottleneck  We did ask for it!  Cystic fibrosis and TB

3.  Sunlight: Vitamin D and Folic Acid  Skin Color o Dark to protect folate o Light to manufacture vitamin D o Inuit  High cholesterol to increase vitamin D  ACHOO  Alcohol flush response (alcohol vs. tea)  Slave trade and salt- evolutionary bottleneck  Environmentally dependent  What happens when the environment changes (moves or migrations?)

4.  The fava bean- Where’s there folklore smoke, there’s medical fire  Free radicals and enzyme deficiency  Fava cultivation and favism o >400 million  Fruit, botanical birth control & poison  JBS Haldane o SCD o Favism o Malaria  Why cultivate what can kill you?