1. Atherosclerosis

2. Normal coronary artery

3. Early coronary atherosclerosis

6. Atherosclerosis
Chronic, progressive, multifocal disease of the vessel wall intima within large /medium sized arteries
Atheroma or plaque formation
İntimal thickening (smooth muscle cell proliferation)
Lipid accumulation

7. Arteriosclerosis
Diffuse process that involves distal vessels well

8. Basic processes in atherosclerosis

9. Stage I
monocyte adhesion/migration through
Vessel wall into intima to become maccrophages
Stage II
foam cells (lipid containing macrophages) in intima
Stage III
appearance of extracellular lipid

10. Fibrous Cap and Core formation
Stage IV
Core formation
(extracellular lipid coalescing into the center of the plaque)
Stage VI
Thrombosis
Stage V
Fibrous Cap and Core formation
(fully formed lipid core and well developed cap of fibrous tissue seperating the core from the lumen)

11. Stable angina. Eccentric coronary stenosis

12. Stable angina. Eccentric coronary stenosis
thick cap

13. Unstable angina with plaque disruption
The plaque cap is torn,
projects into the lumen, exposing a mass of thrombus filling the lipid core

14. Unstable angina with
plaque disruption

16. Causes High blood cholesterol High blood pressure Smoking Obesity
Lack of physical activity

17. Risk Factors Uncontrollable Controllable Sex Hereditary Race Age
High blood pressure
High blood cholesterol
Smoking
Physical activity
Obesity
Diabetes
Stress and anger

18. Treatment
Lipid lowering drugs
Life style modification