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Published byBrittney York Modified over 9 years ago
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Abstract We start with a statistical formulation of Helmholtz’s ideas about neural energy to furnish a model of perceptual inference and learning that can explain a remarkable range of neurobiological facts. Using constructs from statistical physics it can be shown that the problems of inferring what cause our sensory inputs and learning causal regularities in the sensorium can be resolved using exactly the same principles. Furthermore, inference and learning can proceed in a biologically plausible fashion. The ensuing scheme rests on Empirical Bayes and hierarchical models of how sensory information is generated. The use of hierarchical models enables the brain to construct prior expectations in a dynamic and context-sensitive fashion. This scheme provides a principled way to understand many aspects of the brain’s organization and responses. Perceptual inference and learning Collège de France 2008
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Inference and learning under the free energy principle Hierarchical Bayesian inference A simple experiment Bird songs (inference) Structural and dynamic priors Prediction and omission Perceptual categorisation Bird songs (learning) Repetition suppression The mismatch negativity Overview
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agent - m environment Separated by a Markov blanket External states Internal states Sensation Action Exchange with the environment
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Perceptual inference Perceptual learning Perceptual uncertainty Action to minimise a bound on surprise The free-energy principle Perception to optimise the bound The ensemble density and its parameters
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Prediction error Generation Hierarchical models and message passing time Top-down messagesBottom-up messages Recognition
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Empirical Bayes and hierarchical models Bottom-upLateral E-Step Perceptual learning M-Step Perceptual uncertainty D-Step Perceptual inference Recurrent message passing among neuronal populations, with top-down predictions changing to suppress bottom- up prediction error Friston K Kilner J Harrison L A free energy principle for the brain. J. Physiol. Paris. 2006 Associative plasticity, modulated by precision Encoding of precision through classical neuromodulation or plasticity in lateral connections Top-down
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Bottom-up prediction errors Top-down predictions spiny stellate and small basket neurons in layer 4 superficial pyramidal cells double bouquet cells deep pyramidal cells Neural implementation in cortical hierarchies (c.f. evidence accumulation models)
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Inference and learning under the free energy principle Hierarchical Bayesian inference A simple experiment Bird songs (inference) Structural and dynamic priors Prediction and omission Perceptual categorisation Bird songs (learning) Repetition suppression The mismatch negativity Overview
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A brain imaging experiment with sparse visual stimuli V2 V1 Angelucci et al Coherent and predicable Random and unpredictable top-down suppression of prediction error when coherent? CRF V1 ~1 o Horizontal V1 ~2 o Feedback V2 ~5 o Feedback V3 ~10 o Classical receptive field V1 Extra-classical receptive field Classical receptive field V2 ?
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V2 V1 V5 pCG V5 Random Stationary Coherent V1 V5 V2 Suppression of prediction error with coherent stimuli regional responses (90% confidence intervals) decreasesincreases Harrison et al NeuroImage 2006
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Inference and learning under the free energy principle Hierarchical Bayesian inference A simple experiment Bird songs (inference) Structural and dynamic priors Prediction and omission Perceptual categorisation Bird songs (learning) Repetition suppression The mismatch negativity Overview
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Synthetic song-birds Syrinx Neuronal hierarchy
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Song recognition with DEM
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… and broken birds
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… omitting the last chirps
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omission and violation of predictions Stimulus but no percept Percept but no stimulus
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Inference and learning under the free energy principle Hierarchical Bayesian inference A simple experiment Bird songs (inference) Structural and dynamic priors Prediction and omission Perceptual categorisation Bird songs (learning) Repetition suppression The mismatch negativity Overview
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A simple song Encoding sequences in terms of attractor manifolds
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Categorizing sequences 90% confidence regions
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Inference and learning under the free energy principle Hierarchical Bayesian inference A simple experiment Bird songs (inference) Structural and dynamic priors Prediction and omission Perceptual categorisation Bird songs (learning) Repetition suppression The mismatch negativity Overview
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Suppression of inferotemporal responses to repeated faces Main effect of faces Henson et al 2000 Repetition suppression and the MMN The MMN is an enhanced negativity seen in response to any change (deviant) compared to the standard response.
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2500 3000 3500 4000 4500 5000 Prediction error encoded by superficial pyramidal cells A simple chirp
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Perceptual inference: suppressing error over peristimulus time Perceptual learning: suppression over repetitions Simulating ERPs to repeated chirps
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The MMN Enhanced N1 (primary area) MMN (secondary area) Last presentation (after learning) First presentation (before learning) P300 (tertiary area)?
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Summary A free energy principle can account for several aspects of action and perception The architecture of cortical systems speak to hierarchical generative models Estimation of hierarchical dynamic models corresponds to a generalised deconvolution of inputs to disclose their causes This deconvolution can be implemented in a neuronally plausible fashion by constructing a dynamic system that self-organises when exposed to inputs to suppress its free energy Minimisation of free energy proceeds over many spaces, including the state of a model (perception), its parameters (learning), its hyperparameters (salience and attention) and the model itself (selection in somatic or evolutionary time).
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