1. March 19, 2007 Center for Faculty Development and Diversity Office for Postdoctoral Careers Postdoctoral Research Fellow Luncheon Barbara E. Bierer, M.D. Senior Vice President, Research, BWH Director, Office for Postdoctoral Careers (OPC) Director, Center for Faculty Development & Diversity Caroline Rotondi Administrative Director Office for Postdoctoral Careers (OPC) Center for Faculty Development & Diversity

2. Center for Faculty Development and Diversity Office for Postdoctoral Careers OPC Homepage – Recent Updates: http://bwhbri.partners.org/bwh-opc/home.asp Resource Center for Career & Professional Development information: - Knowledge - Best Practices - Ideas - Advice - Helpful Links - Resources Email your content suggestions to BWHPostdocCareers@partners.orgBWHPostdocCareers@partners.org

3. Center for Faculty Development and Diversity Office for Postdoctoral Careers Email your content suggestions to BWHPostdocCareers@partners.orgBWHPostdocCareers@partners.org Postdoc Life @ BWH:

4. Center for Faculty Development and Diversity Office for Postdoctoral Careers Email your content suggestions to BWHPostdocCareers@partners.orgBWHPostdocCareers@partners.org Orientation:

5. Center for Faculty Development and Diversity Office for Postdoctoral Careers Email your content suggestions to BWHPostdocCareers@partners.orgBWHPostdocCareers@partners.org International Center:

6. Center for Faculty Development and Diversity Office for Postdoctoral Careers Email your content suggestions to BWHPostdocCareers@partners.orgBWHPostdocCareers@partners.org Lab Management:

7. Center for Faculty Development and Diversity Office for Postdoctoral Careers Email your content suggestions to BWHPostdocCareers@partners.orgBWHPostdocCareers@partners.org Science & Resources:

8. Center for Faculty Development and Diversity Office for Postdoctoral Careers Upcoming Events: Registration NOT required

9. Center for Faculty Development and Diversity Office for Postdoctoral Careers 4/23Promotions on the Research Track Jaya Kumar, Program Director, HMS Office for Faculty Affairs 5/24Mentoring and Individual Development Plans Orfeu Buxton, Instructor, Division of Sleep Medicine, BWH *4:30pm – 6:00pm BWH Postdoctoral Research Fellow Luncheons Carrie Hall Conference Room 12:30pm – 2:00pm* See BWH Event Calendar for details and registration

10. Center for Faculty Development and Diversity Office for Postdoctoral Careers 4/5Effective Presentations Thomas Lee, M.D., Network President, Partners Healthcare System 4/27Grant Writing Workshop Various Faculty 4/30Effective Negotiations Linda Wilcox, HMS Ombudsperson 5/9How to Get Your Paper Published Caren Solomon, M.D., Associate Professor of Medicine, BWH 6/11Writers Workshop Jaylyn Olivo and Paul Guttry, BWH Editorial Service Career & Professional Development Events See BWH Event Calendar for details and registration

11. Imaging Program Seminar Series Wednesday, April 4, 2007 4:00 - 5:30pm Bornstein Amphitheater Nathan McDannold, Ph.D. Assistant Professor of Radiology MRI-guided Focused Ultrasound: A Noninvasive Method for Thermal Ablation and Targeted Drug Delivery Ron Kikinis, M.D. Director, Surgical Planning Laboratory Professor of Radiology Computerized Image Analysis Please register by sending an email to BWHBRI@partners.orgBWHBRI@partners.org A networking reception will follow in Cabot Atrium. CME Credits are available for this seminar.

12. Brigham Research Community Monthly Forum April 9, 2007 12:00-2:00PM Carrie Hall Conference Room Animal Space Discussion More to follow… Please register at: http://www.brighamandwomens.org/view/EventDetails.aspx?eventID=36809 http://www.brighamandwomens.org/view/EventDetails.aspx?eventID=36809

13. Center for Faculty Development and Diversity Office for Postdoctoral Careers HMS “ RED BOOK” INVITATIONAL RESEARCH FELLOWSHIP & GRANT OPPORTUNITIES CALL FOR NOMINATIONS !!! DUE APRIL 9, 2007 Postdoctoral and Faculty Fellowships/Grants available to HMS include: Burroughs Wellcome Awards, Culpeper Scholarships, Medical Foundation Smith Family New Investigator Awards, Pew Scholars Program, Searle Scholars Program …and many more!!! If you think you are an appropriate candidate for any of the awards listed on the website, please contact your division or department head. Please direct all inquiries to: Office of Academic and Clinical Programs Stacy A. McGrath, 617/432-3667, stacy_mcgrath@hms.harvard.edu or Erin Cromack, 617/432-3633, erin_cromack@hms.harvard.edu http://medapps.med.harvard.edu/fellowships

14. Center for Faculty Development and Diversity Office for Postdoctoral Careers BWH Event Calendar: http://www.brighamandwomens.org http://www.brighamandwomens.org Health Information  Classes and Programs  List Events

15. Center for Faculty Development and Diversity Office for Postdoctoral Careers Professional Pathways Program “What is Technology Transfer and is it a Potential Career Path for You?” Brian N. Hicks, Director, Nicole D. Chiravuri, Ph.D., Licensing Associate, BWH Corporate Sponsored Research & Licensing The BWH Corporate Sponsored Research and Licensing (CSRL) business unit of Research Ventures and Licensing, presents: -a summary of academic Technology Transfer and potential career paths -skills and abilities required for scientists professionally interested in Tech Transfer -day to day aspects of working in the Tech Transfer field.

16. Research Ventures and Licensing Brian N. Hicks, Director Nicole D. Chiravuri, Ph.D., Licensing Associate Corporate Sponsored Research and Licensing Brigham and Women’s Hospital Presentation to: Office for Postdoctoral Careers March 19, 2007

17. Agenda Technology Transfer Overview Licensing Associate Profile Discussion

18. PHS HealthCare Business: Research Profile Largest academic biomedical facility in the world ~1,900 Principal Investigators (MDs, PhDs, MDs/PhDs)* * >5,000 total scientists involved in medical research Principal Investigators as of March ‘06 MGH975 BWH762 McLean132 Spaulding15 Total1,884

19. PHS Research Enterprise: NIH Research Funding Since 1994, PHS Hospitals are the largest (MGH) and second largest (BWH) non-university recipients of NIH research funding 2005* ranking among independent hospitals –FIRST - MGH $287 million 694 awards –SECOND - BWH $253 million 566 awards * Most current available data from NIH

20. Technology Transfer Overview What is it? How does it get transferred? Who owns the technology? Who gets the money? What about funding for research?

21. What is Technology Transfer? Transfer of technological innovation from one party to another for purpose of developing and commercializing useful products – From academia to industry: benefits and challenges for both — and for the investigator/inventor

22. What Technology is Transferred? Intellectual Property – Inventions (usually patentable) New, useful, not obvious Determined by patent lawyers, patent office, courts – Copyrightable works - (mainly software) – Trademarks; trade secrets Tangible Research Property - (unpatentable biological materials) Intangible Research Property – (research results, know-how)

23. More On Patents Legal right to exclude others To preserve patentability: disclose to technology transfer office before public disclosure (oral presentations, publication) because foreign patent protection may be jeopardized (US: one-year grace period; ROW: must be first to file). Loss of foreign patent rights can greatly impact the financial value of an invention

24. Who Owns the Technology and Why? Intellectual Property, TRP: the hospitals Unless: unrelated, no hospital resources, or made under approved consulting arrangement (and no hospital resources) Why? - Federal law: Bayh-Dole Act of 1980 permitting universities/hospitals to elect ownership of inventions made under federal funding - Obligated to have a written policy with its employees requiring disclosure and assignment of inventions and in return must share with the inventor(s) a portion of any revenue received from licensing the invention. - Institutional policy: Intellectual Property Policy

25. How is Technology Transferred? Informally Formally- agreements – Licenses, material transfer agreements, confidentiality agreements, research agreements – Negotiated by technology transfer offices – Signed by authorized institutional representative- investigators not authorized

26. PHS Technology Portfolio FY03FY04FY05FY06 Invention disclosures received 132146164277 US patent filings145151153172 PHS currently has ~900 technologies available for licensing, and our portfolio is grows annually

27. Research Ventures and Licensing (RVL) Number of Agreements Fiscal Year Sponsored Research Agreements Licenses and Options Annual Licenses & Options / Sponsored Research Agreements / Start-Ups Start-Ups PHS Technology Portfolio

28. Selected PHS Licensed Products Embrel Hs CRP diagnostic Licensed to Pepcid Complete FY06 Licensing Income: $328M FY06 Royalty Income: $69M

29. Who Gets The Money?* Inventor(s) (25%): Divided equally among all co-inventors Inventor’s Lab (25%) BWH (25%) Inventor’s Department (25%) *After deducting unreimbursed patent/legal/marketing expenses

30. What About Funding For Research? Industry sponsored research – Part of license package, or separate – Academic rights (publication, collaboration, no secrecy of research results) preserved – Intellectual property rights narrowly defined – Commingling with government funds OK – FY06 PHS Corporate Sponsored Research Expenditures: >$75MM

31. Technology Transfer as a Career Path What is this profession all about? Where do these professionals work? What skills do I need? What do technology transfer professionals do? What are some resources? Where do I start?

32. Where is the Technology Transfer Office? (and what do they do?) There are technology transfer offices at universities, medical schools, hospitals, government agencies and in industry. Most offices provide technology transfer, research support, licensing and start-up activities. Not all technology transfer offices are called the same name or do all the same things! Intellectual Property Office Licensing Office Some are part of a university’s Research Foundation OTL, TLO, TVO, OTTL, TCO, OTD Corporate Sponsored Research and Licensing (CSRL)

33. CSRL is part of Research Ventures and Licensing (RVL) RVL Mission: To support innovative research and the broad translation of Partners HealthCare science to the patient bedside Technology Transfer at Partners HealthCare

34. CSRL (Corporate Sponsored Research and Licensing) –Provides technology transfer, research support, and licensing and start-up activities across MGH, BWH, and other Partners institutions BD (Business Development) –Markets intellectual property and establishes system-wide strategic alliances with the life sciences industries to leverage Partners’ science base CIV (Center for Innovative Ventures) –Promotes a culture of entrepreneurship by educating PHS faculty and supporting the creation and financing of start-up ventures that result from inventions in PHS laboratories CSCR (Corporate Sponsored Clinical Research) –Negotiates agreements and budgets for industry-sponsored clinical research across PHS Research Ventures and Licensing (RVL) Research Ventures and Licensing (RVL) Overview

35. What is a Technology Transfer Professional? Someone who assists in the transfer of technological innovation(s) from one party to another for purposes of developing and commercializing useful products. Different titles depending upon the office: Case Manager Licensing Manager/Associate Business Development Manager Intellectual Property Manager/Associate Industry Agreement Specialist/Associate

36. Who are Technology Transfer Professionals? We come from a variety of backgrounds (some in combination): Science - Ph.D., M.S., B.S. Business – M.B.A., Marketing Law – J.D., patent agent

37. Technology Transfer as a Career Path A Variety of Skills are Needed from: Science Law Business Such as: People Skills Negotiating skillsDecision-making skills Multi-tasking skillsDelegation skills Writing skillsCommunication Skills Management SkillsEvaluation Skills

38. Technology Transfer as a Career Path A Mix of Daily Activities related to: Science Law Business Such as: Negotiating License Term Sheets and License Agreements Reviewing Invention Disclosures and Filing Patents Drafting and Negotiating Agreements (Research, Material Transfer, Confidentiality, Consulting, Interinstitutional, Other) Managing Investigator Portfolios and Existing Licenses Evaluating Potential Start Up Opportunities Interface with OGC, Research Administration, VPs

39. PHS CSRL Agreements in FY 2006 MTA (675) Consulting (696) CDA (302) License/ Options (179) SRAs (104) Gifts/Other Agreements (72) IIA (36) FY2006 Executed Agreements (Total =1794)

40. Learn More about Technology Transfer Association of University Technology Managers (AUTM) http://www.autm.net/index.cfm Bayh-Dole Act Public Benefits of Tech Transfer Licensing Surveys Issues in Technology Transfer Look for a Job Massachusetts Association of Technology Transfer Offices (MATTO) http://www.masstechtransfer.org/index.php Local Events Local Members Look for a Job

41. The Job Hunt No experience in technology transfer? Translate your Ph.D., post-doc, lab life into work experience by highlighting your skills Do an internship (usually unpaid) Go on informational interviews Go to local events and meetings Create a network

42. CSRL: A Day in the Tech Transfer Life... Y4 YEAR 1 Y0 YEAR 2YEAR 3 CM Do Good Dr. Inventor Invention Disclosure Form Review Assignment POA Declaration Contact LicCo Technical Summary CDAs Negotiate License Option Manage LicCo Relationship Review PATENT FILING PROSECUTIONISSUANCE Identify LicCo Start-up? VC?

43. Additional Information In case you’re interested: RVL Website http://www.partners.org/rvlhttp://www.partners.org/rvl BWH CSRL Website http://csrl.bwh.harvard.eduhttp://csrl.bwh.harvard.edu Intellectual Property Policy for Partners-Affiliated Hospitals and Institutions http://intranet.partners.org/OGC/IPPolicy/IP_Index.html http://intranet.partners.org/OGC/IPPolicy/IP_Index.html

44. Questions? Thank you