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CORR Report, 2012: CST Annual General Meeting S. Joseph Kim, MD, PhD, FRCPC Vice President, CORR Board of Directors Friday, February 24, 2012 1.

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Presentation on theme: "CORR Report, 2012: CST Annual General Meeting S. Joseph Kim, MD, PhD, FRCPC Vice President, CORR Board of Directors Friday, February 24, 2012 1."— Presentation transcript:

1 CORR Report, 2012: CST Annual General Meeting S. Joseph Kim, MD, PhD, FRCPC Vice President, CORR Board of Directors Friday, February 24, 2012 1

2 Outline Donor activity Waiting list statistics Transplant activity Transplant outcomes 2

3 Donor Activity 3

4 Deceased Donor Rate (PMP), by Year 4 Source Canadian Organ Replacement Register, 2012, Canadian Institute for Health Information.

5 Deceased Donor Rate (PMP), by Region 5 Source Canadian Organ Replacement Register, 2012, Canadian Institute for Health Information.

6 Deceased Donor Rate (PMP), by Region 6 2001200220032004200520062007200820092010 Deceased Donor13.412.913.312.912.714.114.714.4 13.6 Province B.C.9.17.39.47.45.98.48.812.37.210.8 Alta.17.017.311.416.214.114.813.711.410.68.9 Sask.15.012.017.19.015.110.114.012.812.612.5 Man.7.89.510.36.05.111.012.611.611.515.4 Ont.10.811.311.612.311.813.615.513.616.715.1 Que.18.316.819.018.017.818.2 19.517.615.1 N.B.22.714.716.013.321.313.317.410.714.710.6 N.S./P.E.I.9.711.8 9.613.920.315.017.116.020.1 N.L.28.727.019.39.713.623.59.915.813.89.8 Source Canadian Organ Replacement Register, 2012, Canadian Institute for Health Information.

7 Deceased Donor Rate (PMP), by Age Group 7 Source Canadian Organ Replacement Register, 2012, Canadian Institute for Health Information.

8 Donor Rate (PMP), by Donor Source (Deceased Versus Living) 8 Source Canadian Organ Replacement Register, 2012, Canadian Institute for Health Information.

9 Living Donor Rate (PMP), by Region 9 Source Canadian Organ Replacement Register, 2012, Canadian Institute for Health Information.

10 Number of Canadian Organ Donors, by Donor Source 10 Source Canadian Organ Replacement Register, 2012, Canadian Institute for Health Information.

11 Number of Solid Organ Transplants, by Donor Source 11 Source Canadian Organ Replacement Register, 2012, Canadian Institute for Health Information.

12 Deceased Donor Organ Utilization 12 Source Canadian Organ Replacement Register, 2012, Canadian Institute for Health Information.

13 Canada Deceased Donation, 2001 to 2011 2011: DD = 517, NDD = 449, DCD = 68 (13%) Record year for Canada in both total DD and DCD activity 13 Sources 2001 to 2010: Canadian Organ Replacement Register, Canadian Institute for Health Information; 2011: Personal Communication, Dr. S. Joseph Kim.

14 Province200620072008200920102011 B.C.002017 Alta.001113 Ont.41730373542 Que.0475713 N.S.012022 Total42242434667 Donation After Cardiac Death, by Province, 2006 to 2011 14 Sources 2001 to 2006: Canadian Organ Replacement Register, Canadian Institute for Health Information; 2011: Personal Communication, Dr. S. Joseph Kim.

15 Waiting List Statistics 15

16 Number of Wait-Listed Transplant Candidates, by Organ Type 16 Source Canadian Organ Replacement Register, 2012, Canadian Institute for Health Information.

17 Duration of Dialysis Prior to First Kidney Transplant, by Province, 2008 to 2010 17 Source Canadian Organ Replacement Register, 2012, Canadian Institute for Health Information.

18 Number of Wait-Listed Kidney Transplant Candidates and Death Rates on the Waiting List 18 Source Canadian Organ Replacement Register, 2012, Canadian Institute for Health Information.

19 Number of Wait-Listed Liver Transplant Candidates and Death Rates on the Waiting List 19 Source Canadian Organ Replacement Register, 2012, Canadian Institute for Health Information.

20 Number of Wait-Listed Heart Transplant Candidates and Death Rates on the Waiting List 20 Source Canadian Organ Replacement Register, 2012, Canadian Institute for Health Information.

21 Number of Wait-Listed Lung Transplant Candidates and Death Rates on the Waiting List 21 Source Canadian Organ Replacement Register, 2012, Canadian Institute for Health Information.

22 Number of Wait-Listed Kidney–Pancreas Transplant Candidates and Death Rates on the Waiting List 22 Source Canadian Organ Replacement Register, 2012, Canadian Institute for Health Information.

23 Transplant Activity 23

24 Number of Kidney Transplants, by Donor Type 24 Source Canadian Organ Replacement Register, 2012, Canadian Institute for Health Information.

25 Proportion of Kidney Transplants, by Donor Type 25 Source Canadian Organ Replacement Register, 2012, Canadian Institute for Health Information.

26 Kidney Transplants, by Year and Donor Type, 2001 to 2010 26 Source Canadian Organ Replacement Register, 2012, Canadian Institute for Health Information.

27 Kidney Transplants, by Year and Donor Type, 2001 to 2010 27 Source Canadian Organ Replacement Register, 2012, Canadian Institute for Health Information.

28 Number of Kidney Transplants, by Donor Type and Re-Transplant Status 28 Source Canadian Organ Replacement Register, 2012, Canadian Institute for Health Information.

29 Deceased Donor Kidney Transplants, by Year and Province, 2001 to 2010 29 Source Canadian Organ Replacement Register, 2012, Canadian Institute for Health Information.

30 Deceased Donor Kidney Transplants, by Year and Province, 2001 to 2010 30 Source Canadian Organ Replacement Register, 2012, Canadian Institute for Health Information.

31 Living Donor Kidney Transplants, by Year and Province, 2001 to 2010 31 Source Canadian Organ Replacement Register, 2012, Canadian Institute for Health Information.

32 Living Donor Kidney Transplants, by Year and Province, 2001 to 2010 32 Source Canadian Organ Replacement Register, 2012, Canadian Institute for Health Information.

33 Number of Kidney Transplants, by Diagnosis, 2001 to 2010 33 Source Canadian Organ Replacement Register, 2012, Canadian Institute for Health Information.

34 Kidney Transplant Recipients, by Age Group and End-Stage Renal Disease Diagnosis, 2010 34 Source Canadian Organ Replacement Register, 2012, Canadian Institute for Health Information.

35 Number of Pre-Emptive Kidney Transplants, 2001 to 2010 35 Source Canadian Organ Replacement Register, 2012, Canadian Institute for Health Information.

36 Kidney Transplant Recipients, by Age Group and End-Stage Renal Disease Diagnosis, 2010 36 Source Canadian Organ Replacement Register, 2012, Canadian Institute for Health Information.

37 Number of Kidney Transplants, by Centre, 2010 37 Source Canadian Organ Replacement Register, 2012, Canadian Institute for Health Information.

38 Proportion of Kidney Transplants, Deceased Versus Living Donors, 2010 38 Source Canadian Organ Replacement Register, 2012, Canadian Institute for Health Information.

39 Number of Liver Transplants, by Age, Donor Type and Re-Transplant Status 39 Source Canadian Organ Replacement Register, 2012, Canadian Institute for Health Information.

40 Combination Liver Transplants, Canada, 2001 to 2010 40 Source Canadian Organ Replacement Register, 2012, Canadian Institute for Health Information.

41 Number of Heart Transplants, by Age, Donor Type and Re-Transplant Status 41 Source Canadian Organ Replacement Register, 2012, Canadian Institute for Health Information.

42 Number of Lung Transplants, by Age, Donor Type and Re-Transplant Status 42 Source Canadian Organ Replacement Register, 2012, Canadian Institute for Health Information.

43 Number of Lung Transplants, by Age, Donor Type and Re-Transplant Status 43 Source Canadian Organ Replacement Register, 2012, Canadian Institute for Health Information.

44 Number of Pancreas and Islet Transplants 44 Source Canadian Organ Replacement Register, 2012, Canadian Institute for Health Information.

45 Transplant Outcomes 45

46 Total Graft Survival, First Kidney, by Donor Type, 2001 to 2010 46 Log Rank P < 0.0001 Source Canadian Organ Replacement Register, 2012, Canadian Institute for Health Information.

47 Death-Censored Graft Survival, First Kidney, by Donor Type, 2001 to 2010 47 Log Rank P < 0.0001 Source Canadian Organ Replacement Register, 2012, Canadian Institute for Health Information.

48 Patient Survival, First Kidney, by Donor Type, 2001 to 2010 48 Log Rank P < 0.0001 Source Canadian Organ Replacement Register, 2012, Canadian Institute for Health Information.

49 Total Graft Survival, First Kidney, by Age Group, 2001 to 2010 49 Log Rank P < 0.0001 Source Canadian Organ Replacement Register, 2012, Canadian Institute for Health Information. AgegroupTx1year2years3years4years5years >=65years100.091.687.984.280.276.3 50-64years100.094.091.688.686.783.9 35-49years100.096.394.392.990.888.4 18-34years100.094.892.690.787.384.3 0-17years100.096.293.591.790.487.8

50 Death-Censored Graft Survival, First Kidney, by Age Group, 2001 to 2010 50 Log Rank P < 0.0001 Source Canadian Organ Replacement Register, 2012, Canadian Institute for Health Information. AgegroupTx1year2years3years4years5years >=65years100.095.694.693.292.691.2 50-64years100.096.094.993.592.691.7 35-49years100.096.995.794.893.491.6 18-34years100.095.293.191.488.285.4 0-17years100.096.694.092.390.988.3

51 Patient Survival, First Kidney, by Age Group, 2001 to 2010 51 Log Rank P < 0.0001 Source Canadian Organ Replacement Register, 2012, Canadian Institute for Health Information. AgegroupTx1year2years3years4years5years >=65years100.095.892.990.386.683.6 50-64years100.098.096.594.893.691.4 35-49years100.099.398.698.097.296.5 18-34years100.099.699.499.199.098.7 0-17years100.099.699.499.499.499.4

52 Total Graft Survival, First Kidney, by End- Stage Renal Disease Diagnosis, 2001 to 2010 52 Log Rank P < 0.0001 Source Canadian Organ Replacement Register, 2012, Canadian Institute for Health Information.

53 Death-Censored Graft Survival, First Kidney, by End-Stage Renal Disease Diagnosis, 2001 to 2010 53 Log Rank P = 0.0023 Source Canadian Organ Replacement Register, 2012, Canadian Institute for Health Information.

54 Patient Survival, First Kidney, by End-Stage Renal Disease Diagnosis, 2001 to 2010 54 Log Rank P < 0.0001 Source Canadian Organ Replacement Register, 2012, Canadian Institute for Health Information.

55 Total Graft Survival, First Kidney, by Transplant Era, 2001 to 2010 55 Log Rank P = 0.18 Source Canadian Organ Replacement Register, 2012, Canadian Institute for Health Information.

56 Death-Censored Graft Survival, First Kidney, by Transplant Era, 2001 to 2010 56 Log Rank P = 0.062 Source Canadian Organ Replacement Register, 2012, Canadian Institute for Health Information.

57 Patient Survival, First Kidney, by Transplant Era, 2001 to 2010 57 Log Rank P = 0.40 Source Canadian Organ Replacement Register, 2012, Canadian Institute for Health Information.

58 Liver Transplant Survival, by Age Group, 2001 to 2010 58 Log Rank P =0.07 Source Canadian Organ Replacement Register, 2012, Canadian Institute for Health Information.

59 Liver Transplant Survival, by Donor Type, 2001 to 2010 59 Log Rank P =0.27 Source Canadian Organ Replacement Register, 2012, Canadian Institute for Health Information.

60 Heart Transplant Survival, by Age Group 60 Source Canadian Organ Replacement Register, 2012, Canadian Institute for Health Information.

61 Lung Transplant Survival, by Age Group 61 Source Canadian Organ Replacement Register, 2012, Canadian Institute for Health Information.

62 Summary and Conclusions 62 Gains in deceased donation activity in some regions; activity stagnant in others Donation after cardiac death continues to be a promising means to expand the deceased donor pool Ongoing mismatch between supply and demand for all solid organ transplants Relative stability in number of solid organ donors and transplants over the last several years Favourable outcomes for recipients of solid organ transplants

63 Questions 63

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