1. Delivering clinical research to make patients, and the NHS, better Lymphs & Haems Cancer Research Report Site Specific Group Meeting Weds 11 th March 2015 Maxine Taylor Senior Research Delivery Manager

2. Content of report Update of network changes and objectives Overview of research activity Role of sub specialty research leads & SSG 2

3. 15 Clinical Research Networks in England

4. Purpose of the network Translation of national workstreams and objectives (generic and specialty specific) with strategic oversight of research activity within the geography of CRN - West of England in terms of: –Portfolio Balance, new studies, feasibility, industry trials –Performance Targets, support timely set up, support timely recruitment –People Skill mix, workforce flexibility, training, resources 4

5. Network Clinical Divisions Cancer Division 1 DiabetesRenal StrokeMetabolic & endocrine Cardiovascular Division 2 ChildrenReproductive health & childbirth GeneticsHaematology Division 3 Mental Health Dementias & neurodegenerative diseases Neurology Division 4 Primary careAgeingHealth services research Oral & dentalDermatology MusculoskeletalPublic Health Division 5 ENTAnaesthesia & pain management SurgeryCritical care RespiratoryOpthalmology Critical careInfectious diseases HepatologyGastroenterology Division 6

6. CRN - West of England Management Model Division s 2 & 6 Division s 3 & 4 Division 5 Division 1 Maxine Taylor Senior RDM Workforce Development Mary Griffin RDM RM&G and Industry Lead Ruth Allen RDM Business Intelligence lead Chantal Sunter RDM PCPIE and Comms Lead Mary Perkins Chief Operating Officer

7. The Clinical Team Dr Steve Falk Clinical Director 6 Divisional Clinical Leads Prof Hugh Barr for Div 1 30 Specialty Leads Sub Specialty Leads Sue Taylor Network Consultant Nurse Clinical Research Teams

8. NIHR CRN High Level Objectives Set up as fast as you can Recruit as many and as fast as you can All organisations involved Commercial and non commercial portfolio studies

9. Cancer specific objectives Each network to have a named lead for each of the 13 cancer sub specialties Each sub specialty to have a defined portfolio of available studies 9

10. Cancer Subspecialty Research Leads Mapping onto the national Clinical Studies Groups with the aim of: –Providing link between local network and CSGs –Promoting the research agenda to clinical colleagues across the network and encouraging referrals –Advising on portfolio planning locally –Attendance at annual national meeting to discuss portfolio planning and delivery and horizon scan for new studies – first meeting 9 th March 2015 –Supporting the research delivery manager for the cancer specialty Role complimenting SSG Research Lead role 10

11. Imaging Adv. panel Screening, Prevention & Early Diagnosis CTRad (Radiotherapy) Psychosocial & Survivorship Teenage & Young Adult Teenage & Young Adult Palliative & Supportive Care Palliative & Supportive Care Biomarkers Adv. panel Primary Care Primary Care Consumer Liaison Group Breast Cancer CSG Breast Cancer CSG Lung Cancer CSG Lung Cancer CSG Upper GI Cancer CSG Upper GI Cancer CSG Colorectal Cancer CSG Colorectal Cancer CSG Kidney Cancer CSG Kidney Cancer CSG Bladder Cancer CSG Bladder Cancer CSG Testis Cancer CSG Testis Cancer CSG Gynae Cancer CSG Gynae Cancer CSG PPI Brain Tumours CSG Brain Tumours CSG Head & Neck CSG Head & Neck CSG Sarcoma CSG Sarcoma CSG Melanoma CSG Melanoma CSG Lymphoma CSG Lymphoma CSG Haematol. CSG Haematol. CSG Prostate Cancer CSG Prostate Cancer CSG Children’s Cancer & Leukaemia National Clinical Studies Groups

12. LCRN sub specialty leads NCRI CSGs NIHR CRN cancer leadership 12

13. Division 1 Clinical Lead Brain cancer H&N cancer Lung cancer Breast cancer Sarcoma Skin Cancer Children/young people Upper GI cancer Colorectal cancer Urological cancer Gynae cancer Haem/lymphoma Pall/Supportive & Psychosocial 13 LCRN Subspecialty Leads: LCRN (x15) Clinical Director CRN WE Exec Board COO Division 1 RDM Research Delivery Teams Partnership Group Clin. Advisory Group [ +/- other clinical roles]

14. Cancer specific objectives Action plan in place in each sub specialty to increase access to research eg. –Mapping portfolio across the network –Improve referral pathways for research –Encourage more referral for research –Question sites without key studies –Question sites with studies open without recruitment –Consider economies of scale for rare disease studies 14

15. Cancer specific objectives Recruit at or above national target of 20% incidence Recruit at or above national target of 7.5% incidence for interventional studies Recruit into studies in: –Cancer surgery –Radiotherapy –Rare cancers (incidence <6/100,000/year) –Children’s cancers –TYA cancers 15

16. Overall recruitment as a %age of incidence per LCRN 2014-15 16

17. Interventional study recruitment as a %age of incidence per LCRN 2014-15 17

18. 18

19. 19

20. New studies http://csg.ncri.org.uk/portfolio-maps/

21. Contact & reference details Maxine.taylor@nihr.ac.uk Hugh.barr@glos.nhs.uk http://csg.ncri.org.uk/portfolio-maps/ https://www.edge.nhs.uk/Account/Index?ReturnUrl=%2f http://www.crn.nihr.ac.uk/can-help/funders- academics/nihrcrn-portfolio/http://www.crn.nihr.ac.uk/can-help/funders- academics/nihrcrn-portfolio/ 21