1. Buck Institute for Age Research Review of the Nathan Shock Center of Excellence in Basic Biology of Aging at the Buck Institute for Age Research

2. What are Nathan Shock Centers? First RFA -- 1999 Support Admin core, 2 or more research resource cores, research development core Enhance basic biology of aging research; establish regional/national resources; enhance aging research environment for junior/other investigators Second RFA -- 2004 Fund research and training related to the basic biology of aging Intended for institutions with substantial investment in/commitment to aging research Not intended to support clinical research Third RFA -- 2009 Applications due early May, 2009

3. 1999 -- four centers funded (U Michigan, U Rochester, U Texas San Antonio, U Washington) Buck Institute applied (same yr Buck opened) 2004 -- five centers funded (Buck Institute, Jackson Labs, U Michigan, U Texas San Antonio, U Washington) 2009 -- # to be funded unknown (Buck's competitive renewal)

4. Buck Institute's Nathan Shock Center (organization) Director and PI -- Dale Bredesen (Buck CEO) Transferred to Campisi July, 2008 Administrative Core (Bredesen/Campisi) Four research Cores: Animal/transgenic (Kerby/McDonald, Zhang) Genomics (Melov) Proteomics (Gibson) Imaging (Nicholls/Brand) Research & Development Core (Greenberg)

5. Buck Institute's Nathan Shock Center (resource allocation) Awarded Requested Total award (yr 1): $383 K 633 K Administrative core:$52 K86 K Animal/transgenic core:$60 K 100 K Genomics core:$60 K 101 K Proteomics core:$61 K 102 K Imaging core:$51 K 85 K Research/development core:$99 K 157 K

6. Buck Institute's Nathan Shock Center (activities) Annual Buck symposium (partial) Special courses (2-3/yr) Weekly seminar series (6/yr) High school internships (2/yr) Pilot projects (2/yr) Core activities

8. Buck Institute's Nathan Shock Center (future plans) Continue support for: Research and Development Core (Annual symposium -- partial Seminars -- 4-6 Courses -- 2-3 Pilot projects -- at least 2)

9. Buck Institute's Nathan Shock Center (future plans) Continue support for: Animal core (Reduced emphasis on transgenics Expand with small animal imaging)

10. Buck Institute's Nathan Shock Center (future plans) Continue support for: Genomics core (Incorporate SOLID sequencing Lunyak as co-director)

11. Buck Institute's Nathan Shock Center (future plans) Continue support for: Proteomics core (Biomolecular Mass Spectrometry Core Expand to include lipid, carbohydrate analyses)

12. Buck Institute's Nathan Shock Center (future plans) Continue support for: Imaging core (Bioenergetics and Imaging Core Expand to include Seahorse analyses)

13. Buck Institute's Nathan Shock Center (future plans) Continue support for: Imaging core (Bioenergetics and Imaging Core Expand to include Seahorse analyses)

14. Buck Institute's Nathan Shock Center (future plans) Establish new core: Small molecule screening core (Bob Hughes Tools for drug discovery Tools for animal model testing Tools for pathway identification)