1. Supplementary Fig.1 Native expression Relative expression ratio vs. HKsRNAs a Relative expression ratio vs. pCMX DAOY Med8A Relative expression ratio vs. pCMX Stable overexpression b D458 Med Relative expression ratio vs. pCMX

2. Supplementary Fig.1 Relative expression ratio vs. siCtrl Relative expression ratio vs. siCtrl Transient knockdown DAOY Med8A c Relative expression ratio vs. siCtrl D458 Med

3. Supplementary Fig.2

4. Supplementary Fig.3

5. Molecular subgroup miR-182miR-183 miR-96 Supplementary Fig.4

6. Supplementary Fig. 5

7. Transient knockdown Day Metabolic activity, ratio vs. Day1 Metabolic activity, ratio vs. Day1 Stable overexpression Day Metabolic activity, ratio vs. Day1 Metabolic activity, ratio vs. Day1 DAOY Med8A * * ** Supplementary Fig. 6