1. CUBA CLINICAL TRIALS Dr. Juan C. Vazquez PRACTIHC MEETING

2. 1- Does not exist any National or Official Register of Clinical Trials. 2- Some Institutions maintain its own register. 3- Only finished and published research are available.

3. Sources: MEDLINE (cuba* clinical trial*); CENTRAL [The Cochrane Central Register of Controlled Trials (cuba*)]; web pages of important Cuban research institutions (Infomed, IPK, CECMED) and others (FDA, ICH, self-experience) After excluding duplicated, reports of the same clinical trial, reports of descriptive therapeutic trials without comparisons, etc

4. Antioxidant 2 Asthma & Allergology 13 Cancer 14 Cardiovascular surgery and diseases 12 Gastroenterology 10 Human recombinant epidermal growth factor 1 Human reproduction 12 Immunology 1 Neurology 7 Odontology 2 Policosanol 19 Propoleum 2 Vaccines 19 Total: 114 Total: 114 Range (years): 1973-2002

5. HUMAN REPRODUCTION: 12 1: Study 95915: WHO antenatal care randomised trial for the evaluation of a new model of routine antenatal care. 2- MAGPIE Trial. 3- Study A05217: Comparison of two routes and two intervals of administration of misoprostol for termination of early pregnancy: a randomized multicentre trial. 4- Study A15066: Comparison of two doses and two intervals of misoprostol administration for medical abortion – Clinical Trial. In Progress

6. 1- Estudio Latinoamericano de Cesárea (Latin American Study on Cesarean Section). 2- Medical versus surgical abortion. 3- Oral methotrexate and vaginal misoprostol for early abortion. 4- Misoprostol 3, 4, or 5 days after methotrexate for early abortion. A randomized trial. FINISHED AND PUBLISHED (I) 5- The Latin American Multicenter Trial on psychosocial support during pregnancy: methodology and baseline comparability. 6- Comparative study between IUD TCu 380D and Flexigard.

7. FINISHED AND PUBLISHED (II) 7- The WHO multicentre trial of the vasopressor effects of combined oral contraceptives. 8- Phase I clinical trial of two contraceptive preparations. Norethisterone enanthate (NEN) and norethisterone acetate (NET).