1. S T U S T 1 Development of Portable PAD Assessment System in Diabetic Mellitus Chairman: Dr. Hung-Chi Yang Presenter: Bee-Yen Lim Adviser: Dr. Yi-Chun Du

2. Outline ٥ Introduction ٥ Purposes ٥ Material and Methods ٥ Results ٥ Discussion and Conclusions ٥ References 2

3. 3 Introduction Diabetes is No 4 of the most common cause of death’s ranking in Taiwan and rose by 9% of death increments year by year, it’s beyond higher than any other disease. In 2014, the whole world approximately has 330 million people to suffer from diabetes. Year 20032014(Prediction) Adult Population630 Million People 800 Million People Diabetics’ Amount190 Million People 330 Million People Suffering from of rate diabetes 5.1%6.3% Data source : (Industrial Economics & Knowledge Center ， IEK)

4. 4 Introduction In 2025, Asia will have over 300 million diabetics at the appointed time will burn out the Asian medical system. （ LANCET, 2006 ） Diabetes became the Asian epidemic disease (TIME, 2003)

5. Introduction Chronic disease: A Multisystem Disease ٥ Eye pathological change Soaks for a long time in hyperglycemia‘s small-vessel. ٥ Kidney pathological change Every three nephritis patient simultaneously has one person is the diabetic. ٥ Nerve pathological change The nerve receives the destruction to cause the function damage: The foot pain, bad to the luminance adaptation and easy to tumble. ٥ Foot blood vessel pathological change(PAD) Limps, foot ulcer and fester. 5

6. ٥ Peripheral Artery Disease(PAD) 6 Purposes ٥ The clinical research report that over 25% diabetic concurrent foot ulcer! ٥ Ulcer surpasses 50% are create by PAD, defect patient almost needs to carry on treats positively (surgical operation) ٥ PAD’s patient 50% not subjective symptom; But after if has limps, (Second Stage), some 20% patients need the amputation! ٥ Earlier detection, may effectively reduce ulcer and amputation risks. Diabetic Foot Care, http://physicaltherapy.about.com

7. 7 References ٥ Speckman RA, Frankenfield DL, Roman SH, Eggers PW, Bedinger MR, Rocco MV, McClellan WM (2004) Diabetes Is the Strongest Risk Factor for Lower- Extremity Amputation in New Hemodialysis Patients, Diabetes Care, 27(9): 2198- 2203. ٥ Diabetic neuropathy, http://www.daviddarling.info/encyclopedia /D/diabetic_neuropathy.html ٥ Willian J Jeffcoate,Keith G Harding (2003) Diabetic foot ulcers, The lancet, 361:1545-1551. ٥ Allen, J (2007) Photoplethysmography and its application in clinical physiological measurement, Physiological measurement, 28(3):1-39. ٥ Du, Y.C. and Lin, C.H (2012) Adaptive network-based Fuzzy inference system for assessment of lower limb peripheral vascular occlusive disease, J. Med. Syst, 36(1):301-310. ٥ J.-X. Wu, C.-H. Lin, Y.-C. Du, T. Chen (2012) Sprott chaos synchronisation classifier for diabetic foot peripheral vascular occlusive disease estimation, IET Science, Measurement & Technology, 6(6):533-540.

8. 8 Thanks for your attention!