1. LB145 Sec 001-004

2. Today’s Outline Biology Assessment Introductions Syllabus / Course Overview Class Meetings Introductory Activities What’s coming up in the next few weeks

3. About Me: Who am I? Dr. Pete White email: pwhite@msu.edupwhite@msu.edu Office: E186 [and] NKL 111 Office Hours: TTh 9-10am http://tiny.cc/lb145

4. About You: Who are you?

5. Syllabus / Course Overview This is your education – you have input! – Periodical anonymous feedback on teaching and learning. – Guided independent inquiry in labs. – Flexible grade weightings.

6. Syllabus / Course Overview What are “flexible grade weightings?” There are 750 gradepoints in this course. – 300 are earned in lab (non-flexible). – 450 are earned in “lecture” (flexible).

7. Default Option StudyNotes Option Exams Option Midterm Exam 150 Midterm Exam 2756090 Midterm Exam 3756090 Final Exam10080120 StudyNotes501000 In-Class Exercises30 Homework70 LECTURE TOTAL450 Syllabus / Course Overview Exams67%56%78% Study Notes11%22%0% Exercises + Homework22%

8. Syllabus / Course Overview What are “flexible grade weightings?” There are 750 gradepoints in this course. – 300 are earned in lab (non-flexible). – 450 are earned in “lecture” (flexible). How and when do I choose? – Choices are made after Exam 1 (by Jan 31st) – You will be given a piece of paper, indicate your choice and sign.

9. Syllabus / Course Overview What are StudyNotes? – Go to http://tiny.cc/lb145http://tiny.cc/lb145 – Click on Syllabus and look under sub-heading STUDYNOTES…

10. Syllabus / Course Overview

11. Your FIRST StudyNotes Assignment is due on THURSDAY, Jan 10 th. You need to summarize Chapters 6.3 and 6.4 of the textbook. *See the example on the website for guidance.

12. Syllabus / Course Overview Midterm Exam 1 is on Thursday January 24 th http://tiny.cc/lb145 – Mini-Exam – Covers first ~ three weeks of class. – 50 points – Short Answers + Long Answers – Consult your StudyNotes and Study Questions on the website

13. Syllabus / Course Overview Other important dates: http://tiny.cc/lb145 – Midterm Exam 1 is on Thursday January 24 th Last day to drop course w/ refund February 1st – Midterm Exam 2: Thursday February 28 th Spring Break is March 4 th - 8 th – Midterm Exam 3: Thursday April 11 th – Final Exam: Monday April 29 th, 12:45-2:45 pm

14. Homework SIX homework assignments throughout the year. Your grade is split between the quality of work you hand in AND your ability to evaluate someone else’s work. More details on this next week.

15. I may use TurnItIn for homework assignments in this course. When I do: – I will openly disclose use of Turnitin in this course on the syllabus and at the time assignments are announced. – For a given assignment, I will use Turnitin for all papers. – I will make the final determination of originality and integrity. – To ensure privacy, I will ask students to remove identification (e.g. names & student numbers) from submissions.

16. Syllabus / Course Overview Clickers! – You need a clicker. – You must register your clicker. – iClicker.com

17. Syllabus / Course Overview Honors Option! Something cool? t.b.a.

18. Class Meetings

19. Class Meeting Overview General course structure: – Tuesdays: lecture and class activities Short lecturing blocks interspersed with clicker questions, minute papers, discussions, etc. – Thursdays: activities and problem solving Molecular Sculpting, Match’Em, Trivia Game, DYKWYTYK, etc.

20. Class Meeting Overview WHY not just lecture? – Whoever does the most work learns the most.

21. Attention Span Study Johnstone & Percival Observed 12 lecturers over 90 lectures. Within 10-18 minutes students lost interest. Attention span decreased over the course of the lecture. – By the end, attention span was about 3-4 minutes.

22. Classroom Environment Your Task: Create a classroom code of conduct. WRITE DOWN: List 3 behaviors that we should include in a classroom code of conduct. Think about what others can do to disrupt your learning and/or what other can do to enhance your learning. I will compile the results. We will review them on Thursday and vote on them as classroom code of conduct policy guidelines.

23. Teaching Expectations Class begins at 12:40 and ends at 2:00. Be respectful of students and student learning. I will be organized and prepared. I will follow the syllabus. I will maintain and foster a respectful and inclusive learning environment. I will respect the classroom code of conduct policy guidelines voted on by the class.

24. How to Prepare for Class Complete StudyNotes. – I will not cover 100% of the course material in Tuesday lectures. Do study questions and homework. I will not always post PowerPoint slides before class.

25. Learning

26. What are your learning goals? Develop a list of 3 goals you hope to achieve in this course. List the goals as statements about knowledge skills, behaviors or interests.

27. What are MY goals for your learning? I want you to learn everything you can about proteins. I want you to be able to describe complex micro-biological systems. The course is divided into three units:

28. Unit 1: Cells and Organelles; Membranes and Lipids

29. Unit 2: Cellular Bioenergetics

30. Unit 3: DNA, Gene Expression and Everything in Between

31. Think about Learning…. What is learning?

32. Learning Survey 1.) What is learning? Write a 1-2 sentence definition of learning.

33. Learning Survey 2.) Suppose you have a younger cousin who will be a freshman at MSU next year. She solicits advice from you on how to learn in college. Drawing on your understanding of learning, list 4 recommendations for your friend that would lead to better learning. Explain your reasoning for each of these items.

34. Introductory Activity The case of PARALYIC SHELLFISH POISONING

35. Paralytic Shellfish Poisoning Paralytic shellfish poisoning (PSP) is primarily associated with bivalve mollusks (such as mussels, clams, oysters and scallops). These shellfish are filter feeders and, therefore, accumulate neurotoxins, called Saxitoxin, produced by microscopic algae, such as dinoflagellates, diatoms, and cyanobacteria…. Human toxicity and mortality can occur after ingestion of affected shellfish. The principal toxin responsible for PSP is saxitoxin. Some shellfish can store this toxin for several weeks after a harmful algal bloom passes, but others, are known to store the toxin for up to two years. PSP acts primarily on the nervous system.

36. Paralytic Shellfish Poisoning PSP can be fatal in some cases, particularly in immunocompromised individuals and children. Symptoms can appear ten to 30 minutes after ingestion, and include nausea, vomiting, diarrhea, abdominal pain, tingling or burning lips, gums, tongue, face, neck, arms, legs, and toes. Shortness of breath, dry mouth, a choking feeling, confused or slurred speech, and loss of coordination are also possible.

37. Saxitoxin Sensitivity vs. Saxitoxin Resistance Resistant clams accumulate saxitoxin and are harmful to humans. Not all clams are resistant to saxitoxin: (dead clams  )

38. Minute paper: From a cell and molecular biology perspective, why are some clams resistant to saxitoxin while others are sensitive? HINTS: Resistant clams have the genotype DE or DD. Sensitive clams have the genotype EE. (What does D do?)

39. Answer the following questions: 1.What is a protein? 2.Draw a protein. 3.What does a protein do?

40. Question: What is a Protein? Answer: A chain of amino acids.

41. Question: What does a protein look like? Answer: There are many ways to visualize a protein:

42. Question: What do the D and E alleles do? Answer: They code for different variants of a protein. One version of the protein results in resistance to saxitoxin.

43. Proteins Everything we will learn in LB145 relates to proteins. Unit 1: Proteins and membranes/organelles Unit 2: Proteins and energy Unit 3: Proteins and DNA Proteins are everywhere and do almost everything.

44. Lipids and Lipid biolayers Fluid Mosaic Models How does stuff get into and out of cells? How does stuff move around within cells? Campbell 8e, Fig. 6.12 Unit 1: Cells and Organelles; Membranes and Lipids

45. Building Mental Models Think about a cell membrane – how would you draw one? Membrane?

46. Building Mental Models Cell membrane

47. Looking Ahead..

49. Due on Thursday: Get the Lab Book! Lab starts on Jan. 9 th /10 th Bring your folder (with name, artifact & descriptor). Study Notes are due on Jan 10 th. – READ  Freeman Biology, Sec 6.1-6.4 – Make notes on Carbonless paper for sections 6.3-6.4. – You can find carbonless notebooks on Amazon.com and at most bookstores. Register your clicker. CATME (by midnight tonight)