1. Case Study Student Name: Brittany Dalton Date: 11/9/2010

2. Patient: Cleid Sponger Age: 22 Gender: Male Height: 5’6” Weight: 140 Vital Signs: HR: 65 BPM Respiratory rate: 14 RPM Blood Pressure: 110/70 mm/Hg Temperature: 97.5 Degrees Fahrenheit Chief complaint He is unhappy with the appearance of his teeth and his occlusion. Medical Alert Has hypertension and Osteoporosis, has the syndrome Cleidocranial Dysplasia Name of Syndrome:Cleidocranial Dysplasia Cause of Syndrome - Medical History (if applicable) The RUNX2 gene that is like the master switch for regulating a number of all the genes involved in the development of cells that build bone is decreased or prematurely shortened. This causes a decrease in the protein found in RUNX2. The shortage of this protein causes a problem with normal bone and cartilage development.

3. Orofacial Clinical Features Wide short skull, prominent forehead, wide-set eyes, flat nose, small upper jaw, delayed loss of primary teeth, delayed arrival of permanent teeth, unusually shaped teeth, malocclusion, Supernumerary teeth. Age/race/sex predilections and Systemic Clinical Features: Age and Sex: Always affects people at birth and it doesn’t happen more often in either sex. Race: No discrimination Systemic features: None Clinical features: Short tapered, fingers and broad thumbs, short forearms, Knock knees, abnormal curvature to the spine, absent clavicles, and open fontanelles Radiographic Features of this Syndrome Multiple impacted teeth

4. Special considerations in Treatment of this patient? How is it Diagnosed? How common is it? Is it a horse or zebra? Extractions orthodontia or removing teeth before orthodontic braces. Also may have discomfort sitting in chair for long periods of time because of the scoliosis. Cleidocranial Dysplasia is diagnosed by a genetic disorder, and by defects in the collarbone, late ossification of cranial structures, and delayed tooth eruption. Cleidocranial Dysplasia is common in about 1 per million individuals. Its classified as a Zebra, because it is rare.

5. Pictures of Disease or Syndrome

6. Intraoral Pictures

7. List Sources and References (This should be more than your text book!) Oral Pathology for the Dental Hygienist Fifth Edition www.medicinenet.com/cleidocranial_dyspalsia/article.htm www.google.comwww.google.com Images for Cleidocranial Dysplasia