1. William S. Klug Michael R. Cummings Charlotte A. Spencer Concepts of Genetics Eighth Edition Chapter 18 Cell Cycle Regulation and Cancer Copyright © 2006 Pearson Prentice Hall, Inc.

3. Cancer Is a Genetic Disease About 1% are associated with germline mutations

4. Figure 18-1a Copyright © 2006 Pearson Prentice Hall, Inc.

5. Figure 18-1b Copyright © 2006 Pearson Prentice Hall, Inc.

6. Cancer Is a Genetic Disease What Is Cancer? The Clonal Origin of Cancer Cells Cancer As a Multistep Process, Requiring Multiple Mutations

7. Figure 18-2 Copyright © 2006 Pearson Prentice Hall, Inc.

8. Figure 18-3 Copyright © 2006 Pearson Prentice Hall, Inc. Cancers often develop in progressive steps

9. Cancer Cells Contain Genetic Defects Affecting Genomic Stability and DNA Repair Link: Aneuploidy can cause cancer

10. Figure 18-4a Copyright © 2006 Pearson Prentice Hall, Inc.

11. Figure 18-4b Copyright © 2006 Pearson Prentice Hall, Inc. Homogeneous

12. Figure 18-5 Copyright © 2006 Pearson Prentice Hall, Inc.

13. Gleevec

14. Tomlins et al.

18. Figure 18-6 Copyright © 2006 Pearson Prentice Hall, Inc. HNPCC (hereditary nonpolyposis colorectal cancer) Pedigree – defects in mismatch repair

20. Cancer Cells Contain Genetic Defects Affecting Cell Cycle Regulation The Cell Cycle and Signal Transduction Cell Cycle Control and Checkpoints

21. Figure 18-7 Copyright © 2006 Pearson Prentice Hall, Inc.

22. Figure 18-8 Copyright © 2006 Pearson Prentice Hall, Inc.

23. Figure 18-9 Copyright © 2006 Pearson Prentice Hall, Inc.

24. Figure 18-10 Copyright © 2006 Pearson Prentice Hall, Inc. Apoptosis may occur if damage is severe

25. Many Cancer-Causing Genes Disrupt Control of the Cell Cycle

26. Table 18-2 Copyright © 2006 Pearson Prentice Hall, Inc.

27. Figure 18-11 Copyright © 2006 Pearson Prentice Hall, Inc. Ras proto-oncogenes

28. Figure 18-12 Copyright © 2006 Pearson Prentice Hall, Inc.

29. Figure 18-13 Copyright © 2006 Pearson Prentice Hall, Inc.

30. The p53 Tumor Suppressor Gene (the “guardian of the genome”)

31. Figure 18-14 Copyright © 2006 Pearson Prentice Hall, Inc.

32. The RB1 Tumor Suppressor Gene

33. Figure 18-15 Copyright © 2006 Pearson Prentice Hall, Inc.

34. Figure 18-16 Copyright © 2006 Pearson Prentice Hall, Inc.

35. from Arnold et al. (2005), Cancer 104:2035-2047 Epigentic gene silencing can play a role in cancer

36. Cancer Is a Genetic Disorder Affecting Cell–Cell Contact

37. Figure 18-17 Copyright © 2006 Pearson Prentice Hall, Inc.

38. Predisposition to Some Cancers Can Be Inherited

39. Table 18-3 Copyright © 2006 Pearson Prentice Hall, Inc.

40. Figure 18-18 Copyright © 2006 Pearson Prentice Hall, Inc.

41. Figure 18-19 Copyright © 2006 Pearson Prentice Hall, Inc.

42. Viruses Contribute to Cancer in Both Humans and Animals

43. Figure 18-20 Copyright © 2006 Pearson Prentice Hall, Inc.

44. Table 18-4 Copyright © 2006 Pearson Prentice Hall, Inc.

45. Table 18-5 Copyright © 2006 Pearson Prentice Hall, Inc. New idea about viruses and cancer Research article, Zhao et al 2007 Links:

46. Cervical Cancer Vaccine Gets Injected With a Social Issue Some Fear a Shot For Teens Could Encourage Sex By Rob Stein Washington Post Staff Writer Monday, October 31, 2005; Page A03 Vaccine Prevents Most Cervical Cancer Published: October 7, 2005 http://www.biol.sc.edu/~awaldman/HPVvaccine.htm Link:

47. NYTimes article on new teatment Link:

48. Environmental Agents Contribute to Human Cancers