1. © Copyright 2002 Frost & Sullivan. All Rights Reserved. U.S. Gene Therapy Markets Human Genome Research Accelerates Research “Stringent regulatory requirements will force researchers to undergo rigorous strategic assessments of technologies and clinical approaches.” Drug Discovery and Biotechnology Analyst Team Frost & Sullivan

2. © Copyright 2002 Frost & Sullivan. All Rights Reserved. Frost & Sullivan provides: Detailed insights into recent developments and trends Drivers, restraints, challenges, and strategic recommendations Analytical insights on ‘hot topics’ and emerging applications in the gene therapy markets Market sizing and competitive analysis Market forecasts and opportunity analyses Quarterly assessments End-user analysis in each report Key Features

3. © Copyright 2002 Frost & Sullivan. All Rights Reserved. Coverage: The United States Proven methodology using extensive primary and secondary data and research Focused information and strategies that cover business and technology issues Credible data and analysis highlighting industry dynamics Precise strategies to help you create winning business plans What We Offer

4. © Copyright 2002 Frost & Sullivan. All Rights Reserved. Current Market Participants Find out where you stand in comparison with the competitors Assess current and future drivers and restraints Determine and exploit new market share opportunities New Entrants Analyze challenges associated with the industry Calculate timescales for strategy implementation Position yourself to capitalize on the market’s unmet needs Investment Community Analyze long-term strategies of companies Determine which participants will outperform the competition Assess attractiveness of investing in the market Benefits

5. © Copyright 2002 Frost & Sullivan. All Rights Reserved. Advanced Therapies, Inc. ALZA Corp. ARIAD Pharmaceuticals, Inc. Athersys, Inc. Aventis Gencell Avigen, Inc. BD Biosciences Clontech Bio-Rad Laboratories, Inc. BioStratum, Inc. Biovector Therapeutics, S.A. Cell Gensys, Inc. Dendritech, Inc. Enzo Biochem, Inc. F.H.Faulding & Co Ltd Genelabs Technologies, Inc. Genetic Therapy, Inc. Genetix Pharmaceuticals, Inc. Genetronics Biomedical Ltd. GenStar Therapeutics Corp. GenVec, Inc. Glygen Corp. Immune Response Corp. Inex Intronn LLC InvivoGen Lexicon Genetics, Inc. Nature Technology Corp. Onyx Pharmaceuticals, Inc. Polygenetics, Inc. REPLICor Inc. RHeoGene Ribozyme Pharmaceutical, Inc. Selective Genetics Stem Cells, Inc. StressGen Targeted Genetics Corp. Therion Biologics Corp. Valentis, Inc. ValiGen, Inc. Key Market Participants

6. © Copyright 2002 Frost & Sullivan. All Rights Reserved. Call toll free 877 G O F ROST (877.463.7876) Fax toll free 888.690.3329 E-mail myfrost@frost.com Visit www.frost.com For More Information