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Polypetides and proteins
L.O.: Explain the formation of a peptide (amide) linkage between α-amino acids to form polypeptides and proteins. Describe the acid and alkaline hydrolysis of proteins and peptides to form α-amino acids or carboxylates. Exam qs
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Formation of a dipeptide between glycine and alanine
Peptide: compound containing amino acids linked by peptide bonds. Peptide bond: amide bond in proteins and peptides.
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Formation of a dipeptide between glycine and alanine
Draw an alternative dipeptide made from the condensation of glycine and Alanine.
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Alternative reaction of alanine and glycine
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Section of a polypeptide showing four different amino acids
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Acid hydrolysis of a dipeptide
Reaction conditions: reflux with HCl for 24 hours. 6
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Alkaline hydrolysis of a polypeptide chain
Reaction condition: NaOH, heat Note: sodium salts are formed. 7
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Peptide hydrolysis (powerPoint)
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Draw the organic products formed when the following protein is heated with concentrated hydrochloric acid:
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