1. NIHR CLAHRC for Northwest London Collaborations for Leadership in Applied Health Research and Care November 2008

3. Background to CLAHRC bids Closing the second translational gap - Cooksey ReportClosing the second translational gap - Cooksey Report –‘Accelerating research into better care’ CLAHRC bids aimedCLAHRC bids aimed –Chronic Disease –Public Health Partnerships between NHS and UniversityPartnerships between NHS and University –Broad partnership –Spans the Comprehensive Local Research Network (regional)

4. NIHR CLAHRC for NW London Improve the delivery of innovative research to provide the highest quality of patient care Devise and evaluate a systematic approach for the rapid adoption of clinically effective interventions Develop a model for the conduct and application of health research that is transferable across the NHS Develop research capacity and capability across northwest London

6. The Partnership Chelsea and Westminster NHS Foundation TrustChelsea and Westminster NHS Foundation Trust Imperial College, LondonImperial College, London Acute Trusts in NW LondonAcute Trusts in NW London Primary Care Trusts in NW LondonPrimary Care Trusts in NW London Other NHS OrganisationsOther NHS Organisations –NHS London –NHS Institute for Improvement and Innovation –NHS Direct Other HEIOther HEI –London School of Hygiene and Tropical Medicine CommercialCommercial

7. Delivering an Integrated System

8. Our Focus

9. Sharing Experiences

10. How is this going to work?

11. Funding Sources UKCRN PortfolioUKCRN Portfolio –Funding directed towards high quality research Competitive at a National LevelCompetitive at a National Level Peer ReviewedPeer Reviewed Competitive FundingCompetitive Funding –National Institute for Health Research http://www.nihr.ac.ukhttp://www.nihr.ac.uk –Association of Medical Research Charities http://www.amrc.org.ukhttp://www.amrc.org.uk Commercial FundingCommercial Funding –Research Networks http://www.ukcrc.orghttp://www.ukcrc.org http://www.ukcrn.org.ukhttp://www.ukcrn.org.uk

12. Funding CLAHRC fundingCLAHRC funding –Through host NHS organisation

13. What are the opportunities Increase research capacityIncrease research capacity Awareness of CLAHRC purposeAwareness of CLAHRC purpose Supporting NHS staffSupporting NHS staff –Research –Establishing an evidence base Undertaking researchUndertaking research –Use of information –Knowledge management/transfer E learningE learning –Maximising across the CLAHRC(s)

14. Patient and Public involvement AccessAccess DisseminationDissemination Supporting PPI in generalSupporting PPI in general

15. Q&A www.clahrc-northwestlondon.nihr.ac.uk

17. www.rdfunding.org.uk

19. Funding Applications Read the guidelinesRead the guidelines –Make sure your proposal is within the scope of the bid and meets all criteria Seek financial advice early!Seek financial advice early! –Familiarise yourself with local requirements –Check application guidelines Research Costs (research funder e.g. NIHR, MRC)Research Costs (research funder e.g. NIHR, MRC) NHS Support Costs (DH/NIHR via research networks)NHS Support Costs (DH/NIHR via research networks) Treatment Costs (Commissioning)Treatment Costs (Commissioning)

20. How to improve applications Service user involvementService user involvement –Development of the grant application –Design and management of the research –Undertaking research –Analysis –Dissemination of findings Clear dissemination policyClear dissemination policy Field a strong teamField a strong team Invite critical review before you submitInvite critical review before you submit

21. Ethics and Governance http://www.nres.npsa.nhs.uk/ What requires ethical approval?What requires ethical approval? –Includes tissue and data collection –New IRAS application process (www.myresearchproject.org.uk) Seek advice from your local research officeSeek advice from your local research office –Ethical approval (Site Specific Assessment) –Trust R&D approval –Other approvals EudraCT – registering RCTsEudraCT – registering RCTs MHRA (investigational medicinal products and medical devices)MHRA (investigational medicinal products and medical devices) PIAGPIAG Research Governance FrameworkResearch Governance Framework –Good Clinical Practice Training –Monitoring and Auditing

23. Example: Project Flow

24. Patient and Public Involvement Cascade

25. Shifting the Balance

26. Making Step Change Happen

27. Opportunities I Research Project (site or organisation)Research Project (site or organisation) –Key research staff or delivery staff funded –Training and support from expert team –Peer reviewed publications CLAHRC PartnerCLAHRC Partner –Full access to training programme –Staff development –Dissemination – supported implementation –Support programme

28. Opportunities II Round 1 April 2008Round 1 April 2008 –Medicine management –COPD and Pneumonia –HIV Round 2 and 3Round 2 and 3 –Open competition bids from NW London partnerships –Technology, therapeutics, service delivery –Roll-Out of projects from Round 1 Links with other research programmesLinks with other research programmes Patient and public focusPatient and public focus Action Research and Improvement MethodologyAction Research and Improvement Methodology