Download presentation
Presentation is loading. Please wait.
Published byClinton Price Modified over 9 years ago
3
First month Second Month First month Second Month Milk line remnant Milk line remnant Accessory axillary breast tissue Accessory axillary breast tissue Congenital nipple inversion Congenital nipple inversion
7
Life long breast changes
8
Cyclic hormonal effect
10
Breast abscess Breast abscess
11
Granulomatous mastitis
12
Periductal (recurrent )mastitis
13
Mammary ductectasia
14
Fat necrosis
15
Prolactinoma
18
Fibroademoma Fibroademoma
20
Phyllodes Tumor
22
Sarcoma Radiation induced angiosarcoma
23
Fibrocystic changes
33
Cribriform and solid in situ carcinoma
34
Comedo carcinoma
36
Paget’s disease
37
Infiltrating ductal carcinoma
38
Invasive ductal carcinoma
40
Grading Modified Bloom Richardson Grading System Modified Bloom Richardson Grading System
41
ER PR HER2 P53
43
Metastasis
44
Breast Carcinoma Metastasis
45
Risk Factors Age Age Genetics: BRCA1,BRCA2(first degree relatives) Genetics: BRCA1,BRCA2(first degree relatives) Carcinoma of contralateral breast Carcinoma of contralateral breast Endometrial carcinoma Endometrial carcinoma Reproductive life( early menarche, late menopause) Reproductive life( early menarche, late menopause) Parity( nulliparous > multiparous) Parity( nulliparous > multiparous) First live birth First live birth Race (Northern Europe) Race (Northern Europe) Geographic Influence (immigration) Geographic Influence (immigration) Radiation Exposure (therapeutic or environmental) Radiation Exposure (therapeutic or environmental)
46
Risk Factors Cont’ed Estrogen exposure Estrogen exposure Obesity( specially in postmenopausal state) Obesity( specially in postmenopausal state) Diet Diet Exercise Exercise Breast feeding Breast feeding Environmental toxins Environmental toxins Tobacco Tobacco
47
Prognostic and predictive factors Major: Invasive vs In situ Invasive vs In situ Distant Metastasis Distant Metastasis Lymph node metastasis Lymph node metastasis Locally advanced disease Locally advanced disease Inflammatory carcinoma Inflammatory carcinoma
48
Prognostic Factors cont’ed Minor: Histological type Histological type Tumor grade Tumor grade Estrogen and progesterone receptors Estrogen and progesterone receptors Lymphovascular invasion Lymphovascular invasion Proliferative rate Proliferative rate DNA content DNA content
49
Staging Stage 0: DCIS or LCIS ( 5 year survival 92%) Stage I : Invasive <2 cm, including in situ and microinvasive microinvasive Stage II: Invasive 5cm without nodal involvement involvement Stage III: Invasive>5 cm+ nodal involvement or any breast ca+ fixed L.N, or any breast ca+ fixed L.N, or inflammatory breast cancer inflammatory breast cancer Stage IV: Any form of breast Ca+ distant breast metastasis metastasis
50
Treatment option based on LN involvement 0: No systemic therapy depends on the main tumor tumor 1-3: some form of standard systemic treatment indicated ( hormonal or chemotherapy) indicated ( hormonal or chemotherapy) 4-9: high dose chemotherapy 10 or more: autologous bone marrow transplantation transplantation
52
Lobular Carcinoma
54
Colloid Carcinoma
55
Tubular Carcinoma
56
Medullary Carcinoma
57
Breast B. cell Lymphoma
58
Metastasis to the breast
60
Gynecomastia
61
Male breast Carcinoma
Similar presentations
© 2025 SlidePlayer.com. Inc.
All rights reserved.