1. Profiles Research Networking Software Users Group Meeting http://profiles.catalyst.harvard.edu http://profiles.catalyst.harvard.edu July 19, 2013

2. Agenda Welcome to New Members Upcoming Events Updates Identifying Translational Science

3. Profiles Users Group Members UCSF Fred Hutchinson CRC Oregon Health Sci U Lawrence Berkeley UC Davis (CBST) Touro University U Southern California UCLA UC San Diego Charles Drew U Hawaii Arizona State Montana State U Colorado Denver U Nebraska-Lincoln UW Madison UW-Milwaukee U Illinois U Chicago Baylor College Med UT Southwestern UT Houston Midwestern State Univ Jackson State (RTRN) Ohio State Cincinnati Children’s Case Western U Kentucky Vanderbilt Stem Cell U Arkansas Little Rock U Alabama Birmingham Tulane University Harvard Univ Minnesota Dartmouth Univ Mass Boston Univ Tufts Univ Boston VA Rensselaer Univ Connecticut Univ Rochester NYU Med Ctr Long Island University Stony Brook University Mount Sinai Sch of Med New Jersey Med Sch MedMeme Thomas Jefferson UPenn Johns Hopkins USUHS-CNRM NIH George Wash U Penn State Childrens Nat Med Ctr Duke Cancer Institute Wake Forest Leadership in Med HSSC Georgia Tech Piedmont Healthcare Emory University University of the South Pacific (Fiji) Velammal Engineering College (India) University of Limpopo (South Africa) Nati Sci Lib, Chinese Acad of Sci (China) Clinical & Biomedical Computing Ltd (UK) Jonkoping University Engineering School (Sweden) Universidad Nacional Autonoma de Mexico (Mexico) Ministério da Ciência e Tecnologia e Inovação (Brazil) Jaypee University of Information Technology (India) Zakir Hussain College of Engineering & Technology (India) Faculdade de Engenharia da Universidade do Porto (Portugal) Centre Interdisciplinaire de Nanoscience de Marseille (France) Symplectic Limited (UK) University of Dundee (UK) McGill University (Canada) Finders University (Australia) University of Cambridge (UK) Erasmus University (Brussels) Makerere University (Uganda) Elysium, Geneva (Switzerland) University of Calgary (Canada) University of Leuven (Belgium) South-Valley University (Egypt) University of Salzburg (Austria) Beijing Normal University (China)

4. http://profiles.ucdenver.edu

5. University Spotlights Harvard University http://connects.catalyst.harvard.edu South Carolina http://profiles.healthsciencessc.org Wake Forest Medicne http://profiles.tsi.wakehealth.edu UCSF http://profiles.ucsf.edu UConn Health Center http://profiles.uconn.edu http://profiles.bumc.bu.edu Boston University http://rtrnprofiles.rtrn.net/profilesweb RTRN (18 RCMI Institutions) U. Rochester Med Center http://urmc.rochester.edu/profiles UMASS Medical School http://profiles.umassmed.edu University of Minnesota http://profiles.ahc.umn.edu Penn State http://profiles.psu.edu http://profiles.viictr.org Baylor College of Med

6. Upcoming Events VIVO Annual Conference, St. Louis, Missouri, August 14-16, 2013 [includes a Profiles RNS Workshop] 3 rd Global TechMining Conference (Text-mining, Analysis, and Visualization), Atlanta, Georgia, September 25, 2013 American Medical Informatics Association (AMIA) Annual Symposium, Washington, DC, November 16-20, 2013

7. Identifying Translational Science T1-T4 is qualitative, no consensus on precise definition. Can a bibliometric technique quantitatively identify translation? Weber GM. Identifying translational science within the triangle of biomedicine. J Transl Med. 2013 May 24;11:126. doi: 10.1186/1479-5876-11-126. http://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23705970 Image from http://catalyst.harvard.edu

8. Research Levels - Francis Narin 1976 LevelNameCategoryPrototype Journals 1Clinical Observation Clinical Medicine The Journal of the American Medical Association (JAMA) 2Clinical MixClinical Medicine New England Journal of Medicine (NEJM) 3Clinical Investigation Biomedical Research Journal of Clinical Investigation (JCI) 4Basic ResearchBiomedical Research The Journal of Biological Chemistry (JBC) Narin assigns other journals to a level based on which prototype journals reference it most. Grant Lewison (2004) classifies articles based on whether their titles include one of 100 “basic” or 100 “clinical” keywords.

9. ACH Classification – Weber 2013 Based on MeSH terms assigned to articles “H”: Humans B01.050.150.900.649.801.400.112.400.400 (Human), M01 (Person) “A”: Animals B01 (Eukaryota) [except Human] “C”: Cells and Molecules A11 (Cells), B02 (Archaea), B03 (Bacteria), B04 (Viruses), G02.111.570 (Molecular Structures), G02.149 (Chemical Processes) If multiple terms then AC, AH, CH, ACH

10. ACH Classification – Weber 2013 Category Number of Articles Percent of PubMed Percent in PMC A1,878,6049.4%5.5 C826,4264.1%17.1 H8,676,29443.3%4.9 AC2,015,18110.1%13.5 AH611,0983.1%6.3 CH1,581,2187.9%11.3 ACH714,3723.6%15.2 None3,728,99618.6%7.6

11. Triangle of Biomedicine

12. Triangle of Biomedicine: Disciplines

13. Level 4 Basic Research (JBC) Level 3 Clinical Investigation (JCI) Level 2 Clinical Mix (NEJM) Level 1 Clinical Observation (JAMA) ACHACHAHHCAC Comparison to Research Levels H A C AC CH AH ACH Clinical Medicine Basic Research Clinical Medicine Basic Research

14. Triangle of Biomedicine: Changes over Time

15. Triangle of Biomedicine: Citation Flow

16. Triangle of Biomedicine: Harvard Faculty

17. Triangle of Biomedicine: Harvard Faculty

18. Limitations NLM takes a year or more to assign MeSH terms to articles. Would the results be different using a commercial dataset? “H” category very large. Should there be a “P” category for health practice? Weber GM. Identifying translational science within the triangle of biomedicine. J Transl Med. 2013 May 24;11:126. doi: 10.1186/1479-5876-11-126. http://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23705970 http://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23705970