1. Progress Against Breast Cancer

2. Progress Against Breast Cancer
1970–1979

3. 1970–1979 Progress Against Breast Cancer
1971: More limited mastectomy proven effective for early-stage breast cancer

4. 1970–1979 Progress Against Breast Cancer
1974: Doxorubicin active against advanced breast cancer

5. 1970–1979 Progress Against Breast Cancer
1975: Adjuvant chemotherapy increases cure rates for early-stage breast cancer

6. 1970–1979 Progress Against Breast Cancer
1977: Estrogen receptor status proven to predict risk of breast cancer recurrence
1977: Many women can opt for breast-conserving surgery
1977: Breakthrough drug, tamoxifen, receives initial FDA approval
Late 1970s: Growing use of mammography saves lives

7. Progress Against Breast Cancer
1980–1989

8. 1980–1989 Progress Against Breast Cancer
1986: Tamoxifen reduces breast cancer recurrence

9. Progress Against Breast Cancer
1990–1999

10. 1990–1999 Progress Against Breast Cancer
Mid-1990s: BRCA1 and BRCA2 gene mutations linked to increased breast cancer risk
1994, 2008: Taxanes emerge as vital chemotherapy option for breast cancer

11. 1990–1999 Progress Against Breast Cancer
Mid-1990s: Bone-building drugs help reduce complications of breast cancer and its treatment

12. 1990–1999 Progress Against Breast Cancer
1996: Sentinel lymph node biopsy introduced to assess breast cancer spread

13. 1990–1999 Progress Against Breast Cancer
1998: Oral chemotherapy drug, capecitabine, approved for advanced breast cancer
1998: Drug therapy can reduce breast cancer risk in women at high risk
1998: Chemotherapy before surgery helps more women benefit from breast-conserving treatment
1998: First targeted anti-breast cancer drug, trastuzumab (Herceptin), has major impact on care

14. Progress Against Breast Cancer
2000–Present

15. 2000–Present Progress Against Breast Cancer
2000: High-dose chemotherapy plus stem cell transplant does not improve breast cancer survival
2000: Breast cancer subtypes identified

16. 2000–Present Progress Against Breast Cancer
2002–2004: Novel genetic tests help guide breast cancer therapy

17. 2000–Present Progress Against Breast Cancer
2003: Higher density, shorter term chemotherapy improves breast cancer survival

18. 2000–Present Progress Against Breast Cancer
2004: New class of drugs, aromatase inhibitors, introduced
2004: Adding new drug, gemcitabine, extends survival for some women with advanced breast cancer
2004: Docetaxel helps reduce breast cancer recurrence

19. 2000–Present Progress Against Breast Cancer
2005: Low-fat diet and regular exercise may reduce risk of breast cancer recurrence
2005: Digital mammography more accurate than standard mammography in younger women

20. 2000–Present Progress Against Breast Cancer
2006: Screening, treatment key to declining U.S. breast cancer mortality
2006: Tamoxifen and raloxifene equally effective for preventing invasive breast cancer
2006: Many breast cancer survivors experience fatigue

21. 2000–Present Progress Against Breast Cancer
2007: Lapatinib approved for patients whose HER2-positive breast cancer no longer responds to trastuzumab
2007: MRI screening recommended for women at high risk of breast cancer
2007: Declining breast cancer incidence linked to lower use of hormone replacement therapy
2007: Shorter course of radiation therapy is as effective as less frequent radiation therapy for early-stage breast cancer

22. 2000–Present Progress Against Breast Cancer
2007: First in new class of drugs approved for advanced breast cancer that resists other treatments
2008–2010: Bevacizumab (Avastin) approved for advanced breast cancer

23. 2000–Present Progress Against Breast Cancer
2009: Preventive surgery confirmed to reduce breast and ovarian cancer risk in women with BRCA gene mutations
2009: Standard chemotherapy is an option for older women
2009: PARP inhibitors show promise for difficult-to-treat breast cancers

24. 2000–Present Progress Against Breast Cancer
2010: Targeted drug denosumumab helps prevent common bone-related complications in advanced breast cancer
2010: Removing fewer lymph nodes for some breast cancer patients does not impair survival
2010: New chemotherapy drug improves survival for advanced breast cancer
2011: Aromatase inhibitors cut breast cancer risk among women at high risk

25. 2000–Present Progress Against Breast Cancer
2012: Two targeted drugs together are more potent than one for HER-2 positive breast cancer
: “Armed-antibody” drug improves survival for women with resistant HER2 positive cancers

26. Five-Year Survival Progress Against Breast Cancer
Source: National Cancer Institute

27. Mortality Progress Against Breast Cancer
Source: National Cancer Institute

28. New Cases Progress Against Breast Cancer
Source: National Cancer Institute

29. Visit CancerProgress.Net for an interactive timeline of progress against a range of common cancers
CancerProgress.Net is a project of the American Society of Clinical Oncology, which represents nearly 30,000 physicians who treat people with cancer and research new cures