1. Ravi Chacko CEO Chase McCaleb CFO Walker Plash CMO Perry Yin CTO George Zhou CRO

2. Design Problem Each year in the US 100,000-200,000 people sustain a ruptured or torn ACL. (Mayo Clinic) Surgery >$10,000 Rehab >$10,000 Emotional, social and productivity costs

4. Known Risk Factors Screening for risk factors has shown reduction in injury rates (Hewett) Physiological Factors Hormones, Sex, Leg Dominance, Joint Laxity/Recurvation Behavioral Factors Landing/Jumping Limb position and resulting stresses on knee, hip, and ankle Toe to heel shock absorption Side-step/Cut muscle firing patterns

5. Design Brief Standardize ACL screening and preventative training Method: Measure leg mechanics (e.g. position, angle, forces) during jumping, landing or cutting Determine risk factors and generate personalized training regimen to correct for those factors

6. Constraints and Specifications Health and Safety Should not overexert or injure user Sensor device must be reusable Cost Customers will pay <$500 for this type of diagnostic equipment Insurance may supplement cost Reliability and Use Results promptly displayed after testing Imaging modality has sufficient resolution to determine position accurately Calculations and results must yield significant medical benefit Should allow freedom of movement for accurate results Comfort Device must be comfortable to wear with dimensions similar to athletic clothing Cannot impede usual athletic movement

7. Existing Products Spring Loaded Goniometer Flock of Birds Motion Capture KINE Live Biodex System

8. Components Testing Modality Landing, Cutting, Jumping Sensors Accelerometer Electromyogram (EMG) Goniometer Gyroscopes Pressure Sensor Displacement Sensor Output Risk factors Targeted training regimen Live biofeedback

9. ProLand Risk Factors Tested: Knee Angle Ankle Pronation Components: Gyroscopes Pressure Sensor Display

10. ProCut Risk Factors: Delay in activation of Vastus Lateralis (VL), Semitendinosis (ST) during sidecut Components EMG on VL and ST Accelerometer/gyroscope Display Zebis et al. 2009 VL-ST delay: Risk Group:

11. ProScore Risk Factors: Knee and hip landing angle Ankle and foot arch pronation Ligament Dominance Knee Abduction moment Knee stability (Anterior-Posterior) Components Goniometers Pressure Sensors Gyroscopes Wireless Transmitter Display Hip Angle: Knee Angle: Medial Knee motion: Abduction Moment: Stability: Dynamic Foot Pronation: Ankle Pronation:

12. Thank you Dr. Paul Sadja Associate Professor of Biomedical Engineering Jim Gossett Associate Athletics Director for Sports Medicine Paige Plash Physical Therapist, COO Encore Rehabilitation Dr. Elizabeth Hillman Assistant Professor of Biomedical Engineering Keith Yeager Senior Staff Associate, Laboratory Manager

13. Questions?