1. How to analyse dust in the lung Dr. med. Andreas Burger Zentrum für Medizinische Lehre in der Medizinischen Fakultät der RUB (Center of Medical Education in the Faculty of Medicine) Lehrender des Institutes für Pathologie Ruhr-Universität Bochum (Teacher of the Institute of Pathology) Ruhr-University Bochum Lecture Moscow 27.05.2010

2. © Dr. med. Andreas Burger 2012 How to analyse dust in the lung, lecture Irkutsk 15.10.2012 That is the Problem: A white lung

3. –Silikoses –Asbestoses –Hardmetalfibroses –and so on Lungdiseases conditional on dust © Dr. med. Andreas Burger 2012 How to analyse dust in the lung, lecture Irkutsk 15.10.2012

4. Pulmonal Hypertonus (> 25 mm Hg or 325 kPa) Cor pulmonale –Hypertrophy –and/or –Insufficiency of the right heart Also often causes obstruction Complications © Dr. med. Andreas Burger 2012 How to analyse dust in the lung, lecture Irkutsk 15.10.2012

5. Coal miners Workers in casting Gum manufacture Welding Coating Working with Pesticids, Herbicids, Dioxin Oilrefinerie Cane-sugar manufacture Professions with higher risks on lung diseases with dust © Dr. med. Andreas Burger 2012 How to analyse dust in the lung, lecture Irkutsk 15.10.2012

6. Safe: Arsen, Asbest, Bichlormethylester, Chrome- u. Nickelcompounds, polyzyclic aromatic coal-hydrogens (pacs), Radon, venom gases Suspected: Cadmium, chlorined Toluoles, Dimethylsulfat, Epichlorhydrids, Mineral- fibres, Lead, Silicates, Talcum In question: Acrylnitrites, Beryllium, Vinyl- chloride Dusts with higher risks for lung cancer © Dr. med. Andreas Burger 2012 How to analyse dust in the lung, lecture Irkutsk 15.10.2012

7. gross anatomy of the left lung © Dr. med. Andreas Burger 2012 How to analyse dust in the lung, lecture Irkutsk 15.10.2012

8. subpleural dust and emphysema © Dr. med. Andreas Burger 2012 How to analyse dust in the lung, lecture Irkutsk 15.10.2012

9. Lungfibroses © Dr. med. Andreas Burger 2012 How to analyse dust in the lung, lecture Irkutsk 15.10.2012

10. Microscopy © Dr. med. Andreas Burger 2012 How to analyse dust in the lung, lecture Irkutsk 15.10.2012

11. E nergy D ispersive X -Ray Analysis © Dr. med. Andreas Burger 2012 How to analyse dust in the lung, lecture Irkutsk 15.10.2012

12. Asbestbodies © Dr. med. Andreas Burger 2012 How to analyse dust in the lung, lecture Irkutsk 15.10.2012

13. Trans Electron Microscopy © Dr. med. Andreas Burger 2012 How to analyse dust in the lung, lecture Irkutsk 15.10.2012

14. Trans-, Scanning Electron Microscopy © Dr. med. Andreas Burger 2012 How to analyse dust in the lung, lecture Irkutsk 15.10.2012

15. E nergy D ispersive X -Ray Analysis ( Spectroscopy ) Ferric oxide http://de.wikipedia.org/wiki/Energiedispersive_R%C3%B6ntgenspektroskopie © Dr. med. Andreas Burger 2012 How to analyse dust in the lung, lecture Irkutsk 15.10.2012

16. E nergy D ispersive X -Ray Analysis © http:// marl.iastate.edu Liquid nitrogen Analysis unit by Thermo Scientific – Kevex X-Ray Products 320 El Pueblo Road Scotts Valley, CA 95066 USA © Dr. med. Andreas Burger 2012 How to analyse dust in the lung, lecture Irkutsk 15.10.2012

17. E nergy D ispersive X -Ray Analysis © Dr. med. Andreas Burger 2012 How to analyse dust in the lung, lecture Irkutsk 15.10.2012

18. Dust Inflammation Fibrosis Welding smoke in this case © Dr. med. Andreas Burger 2012 How to analyse dust in the lung, lecture Irkutsk 15.10.2012

19. Gardolineum Contrasting in angiographics New Entity © Dr. med. Andreas Burger 2012 How to analyse dust in the lung, lecture Irkutsk 15.10.2012

20. White lung - lungfibrosis 26 year old man Heroin disease Heroin extended with talcum © Dr. med. Andreas Burger 2012 How to analyse dust in the lung, lecture Irkutsk 15.10.2012

21. Talcum powder © Dr. med. Andreas Burger 2012 How to analyse dust in the lung, lecture Irkutsk 15.10.2012

22. EDX-spectrum of Talcum Powder © Dr. med. Andreas Burger 2012 How to analyse dust in the lung, lecture Irkutsk 15.10.2012