1. Unit 1: DNA and the Genome DNA and the Genome Unit 1: CFE Higher Biology June – October Unit Assessment – before October break

2. CFE Higher Biology DNA and the Genome Key area 1: The structure of DNA

3. CFE Higher Biology DNA and the Genome Take a moment…think… What have you learned about DNA so far? In groups, collect an sheet of poster paper. Nominate a scribe. Write down as many things you can remember about DNA from your school/life so far. DNA

4. CFE Higher Biology DNA and the Genome Carousel Pass the sheets around. Read the facts/comments. Put a tick next to any you had on your sheet. Add any you had that are missing.

5. CFE Higher Biology DNA and the Genome Share with class Share what is on your sheet with the class. The aim is to fill a sheet of your jotter with “DNA background information”.

6. CFE Higher Biology DNA and the Genome Key concepts DNA is inherited. DNA is the genetic material of living things. DNA is located within the nucleus of all cells apart from red blood cells. DNA is a long chemical sequence and this sequence contains the information needed for that living thing to develop, survive and pass its genetic information on to the next generation. The DNA chemical sequence differs between individuals. The pattern of this sequence is called the genotype.

7. Unit 1: DNA and the Genome The structure of DNA

8. CFE Higher Biology DNA and the Genome Prior knowledge DNA is the genetic material.

9. CFE Higher Biology DNA and the Genome Deoxyribonucleic acid The DNA molecule is comprised of two chains of nucleotides. The nucleotides are comprised of a sugar, a phosphate and a base.

10. CFE Higher Biology DNA and the Genome Nucleotides Phosphate Sugar Base 5’ end 3’ end 5’ pronounced “5 prime”

11. CFE Higher Biology DNA and the Genome Why 5’ and 3’? This is what a nucleotide looks like at the molecular level… …lets zoom in to look at the sugar in more detail…

12. CFE Higher Biology DNA and the Genome Carbon 1 Carbon 2 Carbon 3 Carbon 4Carbon 5

13. CFE Higher Biology DNA and the Genome Nucleotides in a chain are joined together by sugar- phosphate bond to make long chains of nucleotides – called polynucleotides. (poly = many)

14. CFE Higher Biology DNA and the Genome The bases In DNA there are four different bases: Adenine Thymine Cytosine Guanine or A, T, C and G

15. CFE Higher Biology DNA and the Genome Base pairing These bases are described as being complementary to each other. This means their shapes match up.

16. CFE Higher Biology DNA and the Genome DNA base pair rules Adenine always joins to Thymine Cytosine always joins with Guanine The bases are joined by hydrogen bonds.

17. CFE Higher Biology DNA and the Genome The double helix The chains of polynucleotides are joined together by the bases, by hydrogen bonds, for form a double helix structure.

18. CFE Higher Biology DNA and the Genome Imagine the sugars and phosphates joined together making the side of a ladder, with the pairs of bases forming the rungs. Then the ladder gets twisted…

19. CFE Higher Biology DNA and the Genome

20. CFE Higher Biology DNA and the Genome The double helix is described as having two anti-parallel chains of nucleotides because one side goes from 5’ to 3’ and the opposite side goes from 3’ to 5’.

21. CFE Higher Biology DNA and the Genome How was all this discovered? Who would have thought that science could produce such a story of intrigue and characters? Like all major scientific discoveries, the discovery of the structure of DNA by James Watson and Francis Crick in 1953 was the result of years of work from a great number of scientists. Not only is the story one of great scientific interest, it is also one of great human interest and controversy.

22. CFE Higher Biology DNA and the Genome Your task This task will see you research one of the individuals or groups of scientists whose work contributed to the discovery. There are six people to choose from and your teacher will help you decide which one to focus on: Griffiths Avery et al. Hershey and Chase Chargaff Franklin and Wilkins Watson and Crick

23. CFE Higher Biology DNA and the Genome The results of your research will then be produced as a scientific poster, which you will present to the class. who the scientist(s) is, where they worked and when the aims of the experiments what the experiments were, including a diagram what the conclusions were other interesting information that you have gathered that lends interest to the story.

24. CFE Higher Biology DNA and the Genome Read the instruction sheet for more details.

25. CFE Higher Biology DNA and the Genome Key concepts DNA is composed of two polynucleotide chains. Nucleotides consist of a sugar, phosphate and base. Nucleotides bond to form a sugar–phosphate backbone. The two polynucleotide chains run antiparallel, with a deoxyribose sugar at the 3′ end and a phosphate group at the 5′ end. The nucleic acid bases are paired by hydrogen bonding in the centre to form a double helix. Base pairing is specific, with adenine pairing with thymine and cytosine pairing with guanine.