1. Foot and Mouth Disease Aphthous fever FMD الحمى القلاعية Foot and Mouth Disease Aphthous fever FMD الحمى القلاعية Bibliotheca Alexandrina 18/3/2012

2. o Epizootic events US 1914-1929 UK 1967 Taiwan 1997 UK 2001 China 2005 UK 2005 Japan and Korea 2010/2011 Bulgaria 2011

3. EGYPT 2006 o Epizootic events Losses up to 900.000 head

4. o What is FMD? VIRAL

5. o Susceptibility

7. o Taxonomy أصله وفصله PicornaviridaePicorna virus Aphthous virus FMD VIRUS FMD VIRUS OAC SAT1SAT2SAT3 ASIA1

8. o Physico-chemical properties ? PH : stable at 7.4-7.6.... ! ! Resistant to : Chloroform Ether Bile salts Detergents ????

9. o Virus Structure General virus structure

11. o Virus Structure 1.Capsid الإطار الخارجى 2.Viral proteins : VP1 VP2 VP2 VP3 VP3 VP4 VP4 3. Nucleic Acid “RNA” ANTIGENICITY إحداث المرض

12. Genetic MaterialViral proteins

13. o Understanding infection

14. o Why Antigenic Variation??!! Evolution of New Subtype Millions of copies + narrow time + LACK OF CORRECTION = Evolution of New Subtype

15. Point mutation o Why Antigenic Variation??!!

16. Point mutation

17. o Prognosis o Morbidity: 100% o Mortality: up to 5% 50-70% in calves 50-70% in calves up to 100% in suckling calves up to 100% in suckling calves

18. o Mode of Transmission

19. Quantitative risk assessment of FMD virus transmission via water. National Institute of Health USA

20. o Clinical Signs الأعراض الإكلينيكية

25. o P.M Examination Calf heart if passed: MYOCARDIOPATHY

26. o How to control ? Isolation of suspected cases

27. o How to control ? Vaccination  Matching and selection..  Emergency vaccination..  Protective Vaccination Vs Suppressive Vaccination..

28. o How to control ? Biosecurity procedures

29. o How to control ? Biosecurity procedures

30. o How to control ? Biosecurity procedures

31. o Public Health concern.. Zoonotic in very limited conditions ?? Milk.. If unboiled ! Occupational.. Vets !

32. o Public Health concern.. Zoonotic in very limited conditions ??

33. o Syndicate Axial Role

34. o References http://www.oie.int/eng/A_FMD2012/docs/2.01.05_FMD.pdf http://www.fao.org/ag/againfo/commissions/docs/training/ material/Diagnostic_sampling_procedures/Diagnostic_sa mpling_procedures.pdf http://www.daff.gov.au/animal-plant-health/pests-diseases- weeds/animal/fmd http://veterinaryextension.colostate.edu/News/dzinfo/Japa n%20FMD%20_2_1%20_2_.pdf