1. Using Fluorescence X-rays for Non-invasive Biopsy Team members: Savannah Gill Kelvin Lin Mike McHugh Trey Reece Derric Williams Advisors: Dr. Frank Carroll Dr. Ed Donnelly Mr. Robert Traeger

2. Project Background/Social Impact Current Methods are Invasive Our Project Hopes To – Rid Detection Process of Needles, Anesthetic, & Pain – Reduce radiation dose to patient – Rid of contrast agent – Reduce Time & Complications http://healtgate.partners.org

3. Project Goals Design beamline components Isolate rings from small angle scattering Figure out which rings represent which elements Distinguish signals from noise

4. Facilities/Resources W.M. Keck Free Electron Laser (FEL) Center at VU – Monochromatic X-ray machine – Specimen for imaging Vanderbilt BME Department – Computers with necessary software http://www.vanderbilt.edu/fel/

5. Project Description X-Ray Fluorescence

6. Project Description Monochromatic X-ray Specimen

7. Project Description Task 1: Decrease the size of the x-ray

8. Task 2: Block off the extra x-ray Project Description

9. Task 3: Determine Material d R Project Description

10. Market Potential Conventional Methods Mammography – High False Negative Rate – Cheap, Simple, Ubiquitous MRI – High False Positive Rate – More Sensitive – More Costly – Safer Mammography X-Ray Image http://history.nih.gov/exhibits/genetics/sect2.htm

11. Market Potential Screening with Monochromatic X-Rays Requires sophisticated equipment Costly Greater sensitivity Safer than conventional mammography Potential use for biopsy upon positive or uncertain mammography

12. Work Completed Completed NCIIA Proposal Researched Journals Constructed Website Submitted Progress Report Finalized team issues

13. Work in Progress Complete Radiation Safety Course Collimation Technique Low Angle Scattering Geometry Calculation Determine Source and Object Distance Weekly advisors meeting and weekly team members meeting

14. Future Work Assess our Financial Needs Gather Appropriate Materials Conduct experiments and perform data analysis

15. Questions?