1. 2005 Beltwide Cotton Conferences Plant Protection and Biotech Products in the Pipeline Frank L. Carter Senior Scientist, Pest Management National Cotton Council National Cotton Council Memphis, TN

2. Plant Protection and Biotech Products in the Pipeline Focus: –New biotech constructs –New active ingredients Pipeline: –Registered within the past year –Expect registration within the year Not include:Not include: –Premixes, co-packs, re-formulations, or generics

3. Plant Protection and Biotech Products in the Pipeline 5 biotech products 20 chemical products

4. Registered: Bollgard II WideStirke LibertyLink / Ignite System Nearing Registration:VipCot Roundup Flex Biotech Products

5. Registered Biotech Products: Bollgard IIMonsantoBt Cotton Int. 2004 IRM = BG WideStrike Dow(Phytogen)Bt Cotton Launch ’05 IRM = BG LibertyLink Bayer(FiberMax) Ignite Tolerant Int. ’04 (<1.5%)

6. Bollgard II Bt toxins Cry1Ac and Cry2Ab CompanyMonsanto Reg. Status Completed 12/03 Target Pests Broad Lep control Varieties 1.5% planted in ’04; see seed companies for 2005 varieties and supplies IRM 80/20; 95/5 Emb. or UT; community

7. WideStrike Bt toxins Cry1Ac and Cry1F Company Dow Agrosciences Reg. Status Completed late ‘04 Target Pests Broad Lep control Varieties Phytogen early-to-mid varieties PHY 440 W (ample supplies) PHY 470 WR (limited supplies) PHY 480 WR (limited supplies) IRM Same as BG and BG II; 80/20; 95/5 Emb. or UT; community

8. LibertyLink / Ignite System Herbicide Tolerant Glufosinate ammonium (Ignite) Company Bayer CropScience Reg. Status Completed Varieties > 1 % planted in ’04; in FiberMax varieties

9. VipCot Bt toxins Vip3A Company Syngenta and DeltaPine Reg. Status Cot 102 first; Cot 200 series Target Pests Broad Lep control VipCot Bt Exotoxin produced during vegetative stages of Bacillus thuringiensis growth IRM Alan McCaffery in Insect Res. Conf.

10. Roundup Flex Glyphosate tolerant CompanyMonsanto Reg. Status EPA- late stages USDA- Late stages FDA- ongoing Use Greater flexibility of timing and rate of glyphosate applications 2005 plans Variety trials, company tests, seed increase; Launch 2006 Info: Monsanto Tech Bulletin; See seed company partners

11. Plant Protection Products Recently Registered (11 products)

12. Diamond Common Name Novaluron Class IGR – 3 rd Gen. chitin inhibitor CompanyCrompton Label Status Registered in May 2004 Primary Target Pests Lepidopteran complex, plant bugs, stink bugs, suppress whiteflies & thrips Comments

13. Zeal Common Name Etoxazole ( V-1283) Class IGR – MOA unclassified CompanyValent Label Status Registered in 2004 Primary Target Pests Mites (eggs and immatures) Comments Long residual molt inhibitor, adult mite sterilant, use with adulticide early in the season, ovicidal activity IRM – 1 use per season

14. Prolex Common Name Gamma cyhalothrin Class 4 th generation pyrethroid Company Dow Agrosciences Label Status Registered in 2004 Primary Target Pests Beet armyworm, lygus, fall armyworm Comments

15. FujiMite Common Name Fenpyroximate Class Company Nichino America Label Status Approved June ‘04 Primary Target Pests Mites Comments

16. Ignite Common Name Glufosinate ammonium Class Inhibits glutamine synthetase Company Bayer Cropscience Label Status Registered in 2004 Use Preplant Burn-down or Hooded in all cottons & Over the top in LibertyLink Comments Novel MOA, controls wide spectrum of weeds, quick kill. FiberMax varieties

17. Valor SX Chateau (CA & AZ) Active Name Flumioxazin Class CompanyValent Label Status Registered in April, 2004 Use Winter weed control, burn down, preplant, preemergence, layby and in-season cotton use Comments

18. Envoke Common Name Trifloxysulfuron sodium Class PPO inhibitor CompanySyngenta Label Status Reg. 2004 Use Post emergence weed control after 5 th leaf, post directed Comments Major broadleaf weeds and sedges

19. Suprend Premix Trifloxysulfuron sodium & prometryn Class CompanySyngenta Label Status Registered Use Broad spectrum herbicide that provides contact & extended control of many tough weeds Timing For post-directed and lay-by applications

20. Sequence Premix Glyphosate & Dual (S-metalachlor) CompanySyngenta Label Status Registered Use Foliar systemic herbicide with residual weed control Comments

21. Dynasty CST 3-Way Premix Fludioxonil (Maxim) Mefenoxam (Apron XL) Azoxystrobin CompanySyngenta Label Status Launch 2006 Use Seed treatment for seedling diseases Maxim – Fusarium & Rhizoconia Apron XL- Pythium Azoxystrobin- pre & post damping off

22. Gaucho Grande Common Name Imidacloprid ClassNeonicitinoid Company Bayer CropScience/ Gustafson Label Status Registered Primary Target Pests Aphids & thrips Comments Seed treatment, higher rate of imidacloprid

23. Plant Protection Products Nearing Registration 9 products

24. Carbine Common Name Flonicamid ( FMC 1785) Class New class of chemistry CompanyISK/FMC Label Status Expect mid-to-late 2005; Primary Target Pests Plant bugs, fleahopper Comments Launch 2006

25. S- 1812 (No Trade Name) Common Name Pyradalyl Class New MOA, not released CompanyValent Label Status Very near registration on cotton Primary Target Pests Leps Comments Demo in ’05, Launch in ‘06

26. Venom Common Name Dinotefuran; V1283 Classneonicitinoid CompanyValent Label Status Very near registration on cotton Primary Target Pests aphids Comments Demo in ’05, launch in ‘06

27. BAS 320 I Common Name Metaflumizone ClassSemicarbizone CompanyBASF Label Status Late 2006; sales 2007 Primary Target Pests Broad spectrum lep activity; Researching plant bug activity Comments

28. Blizzard Common Name Fluthiacet-methyl ClassPGR/Defoliant CompanyCrompton Label Status Project early 2005 UseDefoliant Comments Is PPO inhibitor (related to AIM and ET)

29. STAN (Seed Treatment Against Nematodes) Common Name Abamectin Class CompanySyngenta Label Status Launch 2006 Primary Target Pests Nematodes Comments Seed treatment

30. Topsin M Common Name Thiophanate-methyl Class CompanyCerexagri Label Status Pending Primary Target Pests Reduce Hard Lock Comments Mature fungicide used in more than 25 crops for 25 years

31. Oberon Common Name Spiromesifen ClassKetoenols Company Bayer CropScience Label Status Project early 2005 Primary Target Pests Mites and whiteflies Comments IRM tool - new chemistry and MOA

32. New Product Summary 5 Biotech products5 Biotech products –3 insect protected –2 herbicide tolerant 11 New registered products11 New registered products 9 Nearing Registration9 Nearing Registration

33. Variety of New Products Biotech for insects and weedsBiotech for insects and weeds InsecticidesInsecticides MiticidesMiticides HerbicidesHerbicides DefoliantDefoliant FungicidesFungicides NematacideNematacide Seed treatmentsSeed treatments

34. Acknowledgements: Gerret Van Duyn – NCCGerret Van Duyn – NCC Dr. Jack Reed – Miss. State Univ.Dr. Jack Reed – Miss. State Univ. CompaniesCompanies