1. Interventional MRI Magnetoencephalography
Verification of Functional Imaging with Interventional MRI: Mapping of Epilepsy and Eloquent Cortex

2. Steven Stufflebeam, M.D. (MGH) Ronald Kikinis, M.D. (BWH)
Partners Radiology Research Award

3. Interictal Spike Localization
MEG
This shows some of the information missing from the previous section: timing. In this case the propagation of a spike detected with MEG.
Lower shows the classic way to find epileptic events:EEG. Looking at squiggles, but with a lot of information on the temporal patterns of spontaneous brain activity. No spieks in EEG, but a spike in MEG. Originally thought to be frontal lobe epilepsy

4. Brain Connectivity Structural Connectivity: DTI Tractography
Greg Sorensen
Functional Connectivity:
BOLD fMRI
Vincent & Buckner, 2006
Effective Connectivity:
MEG dynamic SEM
Fa-Hsuan Lin

5. Tumor, MEG, MRAngo, DTI fMRI
Combining Advanced Imaging Technologies: Sum is greater than the Parts
I’m often asked whats the next advancement in imaging, particularly MEG.
Not a single innovation but a more rigorous integration of the existing technologies.
Here is an image make from MEG from MGH and MRI at BWH, in collaboration with Ron Kikinis and Steve Pieper
We’ve extracted information from each technology and put it into a common coordinate system.
This is very simple to do, but can be extremely powerful. It shows how mapping points can be put relative to a tumor (green) an other vital structures (white matter tracks)
How can we intelligently put these together? Including intraoperative mapping (often the goal standard, but it’s an arrest similar to tMS)
Tumor, MEG, MRAngo, DTI fMRI
Stephen Piper, Ph.D.

6. Language Mapping in Temporal Lobe Tumor
T2 MRI Tumor
Isopoential Field Maps (MEG)
DTI
MEG Dipole For Language Stimuli
Dr. Alexandra Golby
Dr. Ralph Suarez
Dr. Ronald Kikinis.
Dr. Stufflebeam C

7. Dr. Alex Golby Dr. Ralph Suarez. Dr. Stufflebeam
Blue blobs represent MEG language localizations. Red blobs represent fMRI language localizations. Brown cords represent white matter tractography. Green blob represents the tumor lesion. Red tags represent intra-operative language mapping sites ascertained by intra-operative ECS. Note the regions where MEG and fMRI language overlap, these co-localizations were used as seeding points for tractography generation. Note the unsafe distance observed here between the tumor lesion and functional language systems.
Dr. Alex Golby
Dr. Ralph Suarez.
Dr. Stufflebeam

8. Why is this research important?
Translational research: bench to bedside.
Multidisciplinary and cross-institutional: Physics, software engineering, mathematics, neurosurgery, neurology.
Leverages the resources of the BWH & MGH to advance researchdirectly to patients/physicians.
250 epilepsy & brain tumor patients from MGH/BWH
Awards at ISCAMEG, HBM, ISB
HST.583 Imaging Biophysics & Clin Apps
Grants R01, P41, K08, K25, CIMIT

9. Thanks BWH MGH/Martinos Center Ron Kikikis Stephen Piper Ferenc Jolesz
Ralph Suarez
Alexandra Golby
Joseph Madsen
Ed Bromfield
Barabara Dworetzky
Jong Lee
Emad Eskandar
Reese Cosgrove
Andy Cole
Ronan Kilbride
Matti Hamalainen
Fa-Hsuan Lin
Greg Sorensen
Randy Buckner
Gordon Harris
Giorgio Bonmassar