1. National Institutes of Health (NIH) Training Opportunities to Develop Scientists Jane D. Scott, ScD, MSN, FAHA Director, Office of Research Training & Career Development Division of Cardiovascular Sciences National Heart, Lung, and Blood Institute National Institutes of Health Cleveland State University Colleges of Sciences and Health Professions April 11, 2013

2.  NIH’s role in research & research training  Identify research training opportunities for individuals interested in pursuing a research career.  Identify programs for PhDs and clinician scientists  Provide links to NIH resources Goals for today 2

3. National Institutes of Health The NIH is part of the U.S. Department of Health and Human Services (HHS). 3

4. National Institutes of Health The National Institutes of Health (NIH) is the largest source of funding for biomedical research in the world, making important medical discoveries that improve health and save lives. 4

5. What is Biomedical Research? Biomedical research advances knowledge in biology and medicine and related fields. 5

6. National Institutes of Health 6

7. NIH Funding: 27 Institutes and Centers 7

8. Most NIH Funds Are Spent Beyond Bethesda NIH Budget FY 2010: $30.759 B At NIH (intramural): $3.22 (11%) Outside NIH (extramural): $26.3 B (89%) 8

9. NIH Research Funding Cleveland State University Today

10.  5 R01 AG039547 02 CIRCADIAN CLOCK AND DIETARY RESTRICTION KONDRATOV, ROMAN V CLEVELAND STATE UNIVERSITY 2012 NIA $291,100 5R01AG03954702CIRCADIAN CLOCK AND DIETARY RESTRICTION KONDRATOV, ROMAN V  5 R01 AI066095 07 CHARACTERIZE FUNCTIONS OF T. BRUCEI RAP1 AND TRF IN ANTIGENIC VARIATION AND TELOM LI, BIBO CLEVELAND STATE UNIVERSITY 2013 NIAID $319,500 5R01AI06609507CHARACTERIZE FUNCTIONS OF T. BRUCEI RAP1 AND TRF IN ANTIGENIC VARIATION AND TELOMLI, BIBO  5 R01 HL079164 08 TRANSLATIONAL SILENCING IN MONOCYTES: ROLE OF L13A MAZUMDER, BARSANJIT CLEVELAND STATE UNIVERSITY 2012 NHLBI $351,464 5R01HL07916408TRANSLATIONAL SILENCING IN MONOCYTES: ROLE OF L13AMAZUMDER, BARSANJIT  5 R01 HL102604 04 RECOMBINANT AND CHEMO-/BIO-ORTHOGONAL SYNTHESIS OF LIPOSOMAL THROMBOMODULIN SUN, XUE-LONG CLEVELAND STATE UNIVERSITY 2013 NHLBI $284,675 5R01HL10260404RECOMBINANT AND CHEMO-/BIO-ORTHOGONAL SYNTHESIS OF LIPOSOMAL THROMBOMODULINSUN, XUE-LONG  1 R01 NS081710 01 RESTORING UPPER LIMB MOVEMENT SENSE TO AMPUTEES; A MOVE TOWARDS NATURAL CONTROL O MARASCO, PAUL CLEVELAND VA MEDICAL RESEARCH/ED/FDN 2012 NINDS OD $327,033 1R01NS08171001RESTORING UPPER LIMB MOVEMENT SENSE TO AMPUTEES; A MOVE TOWARDS NATURAL CONTROL OMARASCO, PAUL NIH funding at Cleveland State University 10

11.  1 R03 CA159906 01A1 THE CONTEXT OF CAREGIVING AND BEREAVEMENT ADJUSTMENT IN LATE-STAGE CANCER FRANCIS, LINDA E CLEVELAND STATE UNIVERSITY 2012 NCI $71,0001R03CA15990601A1THE CONTEXT OF CAREGIVING AND BEREAVEMENT ADJUSTMENT IN LATE-STAGE CANCERFRANCIS, LINDA E  1 R15 AI103889 01 DRUG DEVELOPMENT OF ORALLY ACTIVE ANTI- TRYPANOSOMIASIS AGENTS SU, BIN CLEVELAND STATE UNIVERSITY 2013 NIAID $436,5001R15AI10388901DRUG DEVELOPMENT OF ORALLY ACTIVE ANTI- TRYPANOSOMIASIS AGENTSSU, BIN  1 R15 DK092716 01 FLUID FLOW MAY BE AN ENVIRONMENTAL MODIFIER OF ADPKD DISEASE PROGRESSION RESNICK, ANDREW CLEVELAND STATE UNIVERSITY 2011 NIDDK $332,344 1R15DK09271601FLUID FLOW MAY BE AN ENVIRONMENTAL MODIFIER OF ADPKD DISEASE PROGRESSIONRESNICK, ANDREW  1 R15 GM099056 01 CONTROL OF PAIRING AND RECOMBINATION DURING MEIOSIS BOERNER, VALENTIN CLEVELAND STATE UNIVERSITY 2011 NIGMS $284,000 1R15GM09905601CONTROL OF PAIRING AND RECOMBINATION DURING MEIOSISBOERNER, VALENTIN   1 S10 OD010381 01 NIKON A1RSI CONFOCAL MICROSCOPE BARIK, SAILEN CLEVELAND STATE UNIVERSITY 2012 OD $590,931 1S10OD01038101NIKON A1RSI CONFOCAL MICROSCOPEBARIK, SAILEN NIH funding at Cleveland State University 11

12. Are you interested in a research career? 12

13. Awards for individuals with a Health-Professional Doctorate 13 Mentored Patient-Oriented Research CDA (K23)

14.  Institutional T32 Training Programs for pre & post-docs  Individual Fellowship Grants (F awards)  Institutional Career Development Awards (K)  Individual Career Development Awards NIH Research Training: 4 key programs

15. Research Training: T32 15

16. Research Training: T32 16

17. NIH Training (T) grants, Midwest 356 programs for 101M

18.  Individual pre and post doctoral awards  Generally after T32 training  2-3 years of additional research  F31  F32  F30 Fellowship Awards

19.  Please note, there can be big difference between NIH and Institute specific programs  NHLBI F31 individual predoctoral fellowships are to Promote Diversity in Health Related Research  For individuals with disabilities,  or from underrepresented racial and ethnic groups,  or individuals from disadvantaged backgrounds pursuing advanced degrees in biomedical and behavioral sciences.  Up to 5 years support, must have US citizenship  For pursuit of PhD or comparable degree F31 Fellowship

20.  Individual award  Postdoctoral support  Up to 3 years full-time support  Frequently transition from T32 to F32  Includes stipends, tuition and fees, more F32 Fellowship

21.  Individual award  Combined MD/PhD program  Up to 6 years of support  Only training award that supports tuition for medical school  Citizenship required  Extremely competitive award F30 Fellowship

22. Individual K Awards (early faculty): 22

23. Individual K awards: 23

24.  Joint K/R program  Mentored career development (K99) 2 years  Independent research (R00) 3 years  Must be a post-doc  Rules are changing (<5 yrs chg to <4 yrs)  Overwhelmingly utilized by PhDs  No citizenship requirements  Current discussion for broad expansion across NIH K99/R00 grant

25.  Supplements are available for some research awards, & each institute different  HS, undergrad, pre, post, early faculty  Requested by the R01 Principal Investigator  Supports the conduct of research by supplement awardees for 2-3 years.  http://www.nhlbi.nih.gov/funding/training/guid-app.htm http://www.nhlbi.nih.gov/funding/training/guid-app.htm NIH Diversity Supplement Awards

26. NIH Loan Repayment Programs 26

27. NIH Loan Repayment Programs 27

28. Getting started: 28

29. Getting started: 29

30. RePORT & RePorter: http://report.nih.gov 30

31. Am Heart J 2011;161:13-67 31

32. K08 and K99 Cardiovascular Training : Comparisons and Trends Among Current Awardees Authors Jane Scott & Drew Carlson Analyzed 150 K08 & K99 awards Includes tips on writing a competitive K award Circ Res. 2012;110:910-914

33. For more information 33

34. http://projectreporter.nih.gov/reporter.cfm http://grants.nih.gov/grants/oer.hhtm www.nih.gov www.nhlbi.nih.gov For more information

35. Office of Research Training & Career Development, Division of Cardiovascular Sciences, NHLBI, NIH: 301.435.0545 Jane Scott, ScD, MSN Drew Carlson, PhD Tawanna Meadows, BS

36. Questions??? NIH Research Training Opportunities

37. NHLBI: People…Science…Health 37