1. OSTEOARTHRITIS

2. Osteoarthritis (OA) is a common, degenerative disease, which is characterized by local degeneration of joint cartilage and new bone formation at the base of the cartilage lesion (subchondral bone) and at the joint margins (osteophytes).

3. Osteoarthritis is the result of both mechanical and biologic events that destabilize the normal coupling of degradation and synthesis of articular cartilage and subchondral bone

4. Risk factors Older age - Osteoarthritis typically occurs in older adults. People under 40 rarely experience osteoarthritis. Sex - Women are more likely to develop osteoarthritis, though it isn't clear why. Bone deformities - Some people are born with malformed joints or defective cartilage, which can increase the risk of osteoarthritis. Joint injuries - Injuries, such as those that occur when playing sports or from an accident, may increase the risk of osteoarthritis. Obesity - Carrying more body weight places more stress on your weight-bearing joints, such as your knees. But obesity has also been linked to an increased risk of osteoarthritis in the hands, as well. Other diseases - that affect the bones and joints. Bone and joint diseases that increase the risk of osteoarthritis include gout, rheumatoid arthritis, Paget's disease of bone and septic arthritis.

5. Risk factors Older age Osteoarthritis typically occurs in older adults. People under 40 rarely experience osteoarthritis.

6. Risk factors Sex Women are more likely to develop osteoarthritis, though it isn't clear why.

7. Risk factors Bone deformities Some people are born with malformed joints or defective cartilage, which can increase the risk of osteoarthritis.

8. Risk factors Joint injuries Injuries, such as those that occur when playing sports or from an accident, may increase the risk of osteoarthritis.

9. Risk factors Obesity Carrying more body weight places more stress on your weight- bearing joints, such as your knees. But obesity has also been linked to an increased risk of osteoarthritis in the hands, as well.

10. Risk factors Other diseases That affect the bones and joints. Bone and joint diseases that increase the risk of osteoarthritis include gout, rheumatoid arthritis, Paget's disease of bone and septic arthritis.

11. FACTORS 1.Genetic 2.Developmental 3.Metabolic 4.Traumatic

12. Classification Primary Aging Sex Secondary Congenital disorders of jointsCongenitaldisorders Diabetes.Diabetes Inflammatory diseases (such as Perthes' disease), (Lyme disease), and all chronic forms of arthritis (e.g. costochondritis, gout, and rheumatoid arthritis). In gout, uric acid crystals cause the cartilage to degenerate at a faster pace. Perthes' diseaseLyme diseasecostochondritisgout rheumatoid arthritisuric acid Injury to joints, as a result of an accident or orthodontic operations.Injury accident Septic arthritis (infection of a joint )Septic arthritis Ligamentous deterioration or instability may be a factor.Ligamentous Marfan syndrome Obesity Alkaptonuria Hemochromatosis and Wilson's diseaseHemochromatosisWilson's disease

13. OA may affect every joint

20. DEGENERATION OF THE ARTICULAR CARTILAGE

21. Symptoms Pain in a joint during or after use, or after a period of inactivity Tenderness in the joint when you apply light pressure Stiffness in a joint, that may be most noticeable when you wake up in the morning or after a period of inactivity Loss of flexibility may make it difficult to use the joint Grating sensation when you use the joint Bone spurs, which appear as hard lumps, may form around the affected joint Swelling in some cases

22. Heberden's nodesHeberden's nodes may form in osteoarthritis

23. Diagnosis X-RAY Primary osteoarthritis of the left knee. Note the osteophytes, subchondral cyst formation, narrowing of the joint space (arrow), and increased subchondral bone density (arrow).osteophytescyst

24. Diagnosis Arthroscopy

25. NON-DRUG TREATMENT weight loss (normal weight people have a 20% risk of hip OA, overweight have 25% risk, and obese have 39% risk) water exercise programs physical therapy (range of motion and strengthening exercises) occupational therapy (assistive devices, joint protection) patient education

26. DRUG TREATMENT Acetaminophen Non-steroidal anti- inflammatory drugsNon-steroidal anti- inflammatory drugs Tanezumab (monoclonal antibody)Tanezumab Chondroitin sulfate Glucosamine S-Adenosyl methionine

27. Surgery

28. INTRAARTICULAR INJECTION Artificial synovial fluid Steroids Enzyme inhibitors Chondroprotectors

29. INTRAARTICULAR INJECTION

30. Surgeory Autologous chondrocyte implantation Microfracture surgery Arthroscopic surgery Arthroscopic surge Osteotomy Limb lengthening Arthrodesis Joint replacement

31. Deformity correction

33. Limb lengthening

34. Arthrodesis of ankle joint

36. Subtalar arthrodesis

38. TOTAL SHOULDER REPLACEMENT

39. TOTAL ELBOW REPLACEMENT

40. TOTAL HIP REPLACEMENT

41. TOTAL KNEE REPLACEMENT

42. TOTAL ANKLE REPLACEMENT