1. Dr. Peter J.E. Verdegem Chief Scientific Officer

2. VisuTein: A powerful protection for age-related eye disorders

3. The human eye: anatomy

4. A trip through the eye

5. 42% 23% 16% 14% 5% Cataract Degenerative diseases Trachoma Glaucoma Nyctalopia Different causes of blindness in the world Data: WHO

6. Cataract Scene with normal visionScene with cataract vision Pictures: NEI

7. Glaucoma Scene with normal visionScene with glaucoma vision Pictures: NEI

8. Age-related Macula Degeneration Scene with normal visionScene with AMD vision Pictures: NEI

9. AMD & Amsler grid Normal AMD

10. Eye diseases: current treatments Cataract –Lens extraction AMD –Laser surgery Glaucoma –Drug therapy –Laser surgery –Conventional surgery Cataract –Lens extraction AMD –Laser surgery Glaucoma –Drug therapy –Laser surgery –Conventional surgery Prevention

11. Cataracts: biological background Disfunctional Proteases Accumulation of damaged proteins Cataract Proteases Removal damaged proteins Protein Oxidized Proteins Sun lightOH O 2 – H2O2H2O2 GSH peroxidase Catalase SOD Beta-carotene Vitamin E, C

12. Multi Action System Protection against oxidative stress Important nutrients Ingredients for specific eye diseases

13. Module 1 I Vitamin C Vitamin E Beta carotene Direct antioxidants

14. 0 0,2 0,4 0,6 0,8 1 1,2 1,4 1,6 1,8 MultivitaminsVitamin CVitamin E Jacques, PF; Int. J. Vitam. Nutr. Res. 1999; 69:198. Antioxidants: Studies for Cataract

15. Intake Studies for cataracts 0 0.5 1 1.5 2 2.5 3 3.5 4 Relative Risk CarotenoidsLuteinCarotene

16. Module 1 I Vitamin C Vitamin E Mixed carotenoids Selenium Zinc Copper Vitamin B6 N-acetyl-L-cystein Direct antioxidants Co-factors for enzymatic antioxidant defence Glutathion synthesis stimulation Herbal antioxidant source Vaccinium myrtillus

17. Herbal antioxidants Rich in anthocyanosides Stimulant of visual acuity Morazzoni, P et al; Fitoterapia 1999; 67:3.

18. Module 2 I Vitamin A Beta carotene Important nutrients

19. Module 3 Lutein Zeaxanthin III Macula pigments

20. Macular pigment: lutein and zeaxanthin Zeaxanthin Lutein Function Structural UV-protection Source Dark green leafy vegetables

21. -4 -2 0 2 4 6 8 10 12 14 -15-10-5051015 0 0,5 1 1,5 2 2,5 Dist from centre (mm) Macular pigment: lutein and zeaxanthin Lutein Zeaxanthin Landrum; Arch. Bioch. Biophys. (2001); 385:28.

22. Lutein supplementation Landrum, J et al; Am. J. Clin. Nutr. 2000; 72:844.

23. Clinical Study with VisuTEIN Louisiana Retinal Institute Dry AMD patients Study versus OcuVite Improvements –Recovery from a flash –Contrast sensitivity –Visual Acuity Louisiana Retinal Institute Dry AMD patients Study versus OcuVite Improvements –Recovery from a flash –Contrast sensitivity –Visual Acuity

24. Lutein and visual acuity in AMD 0% 20% 40% 60% 80% 100% LuteinPlacebo Worse Equal Better Massacesi, AL et al; Invest. Opth. Vis. Sci 2001; 42:S234.

25. Multi Action System Providing nutrients Improving actuity Antioxidant protection

26. Dr. Peter J.E. Verdegem Chief Scientific Officer