1. Overview of Tuberculosis in Deer Classical Pathology and Immunology The Many Hosts of Mycobacteria II: Immunopathology Gettysburg, PA

2. Natural: oral, aerosol Routes of infection Tonsil Retropharyngeal LN Lung and LNs Hepatic LN Parotid LN 38% 45% of naturally infected deer have extracranial lesions Experimental: intratonsilar (40 CFU) 300 CFU- 83% infection rate Red deer (Cervus elaphus) 100-500 CF- 80-90% infection

3. Day 90Day 28 Day 180 Day 328 148 days post-contact

4. Day 28 Day 60 Day 180 Day 328

5. Immunopathology in WTD Re-stimulate isolated PBMC with PPD or E:C

6. GATA3 Responses to M. bovis Infection

7. IL-17 Responses to M. bovis Infection