1. Tuberculosis Ivan Štironja Mentor: A. Žmegač Horvat

2. Honoré de Balzac Alber Camus Franz Kafka Voltaire Frederic Chopin Niccolò Paganini Alexander Graham Bell John Henry Doc Holliday René Laënnec Immanuel Kant Florence Nightingale "Captain among these Men of Death" (John Bunyon 1660) White Death White Plague Consumption Tuberculosis...

3. Mycobacterium tuberculosis - Gram positive, obligate aeorobe, facultative intracellular pathogens - Slow-growing - generation time 12 - 18 hours - Hydrophobic with high lipid content in cell wall - "acid-fast bacilli“ - transmission primarily by aerosol route but also through gastrointestinal tract

6. MDR-TB (Multi-drug resistant tuberculosis) : bacteria resistant to isoniazid and rifampicin HIV/AIDS

7. granulomatous inflammatory disease caused by mycobacteria, usually attacks the lungs (pulmonary tuberculosis – 75%), but can also affect: – CNS – lymphatic system – circulatory system – genitourinary system – gastrointestinal system – bones (Pott’s disease) and skin tubercle (Lat. tuber-knot) – granuloma made of macrophages, T-lymphocytes, B-lymphocytes and fibroblasts surrounding the central caseous necrosis

9. Symptoms chronic cough blood-tinged sputum fever night sweats weight loss weakness or fatigue

10. Diagnosis identification of the causative organism in a clinical sample (sputum) PPD test (Mantoux tuberculin test) X-rays

12. Treatment BCG vaccination (Baccillus Calmette-Guérin) first-line anti-TB drugs: isoniazid, rifampicin, streptomycin, ethambutol, pyrazinamide second-line anti-TB drugs: rifabutin, ethionamhide long-term treatment

13. World TB day - March 24 15 billion US$

14. References Patologija, Damjanov, Jukić, Nola, Med. naklada, Zagreb,2008. Medicinska bakteriologija i mikologija, Kalenić, Mlinarić-Missoni i sur., Zagreb, 2005. internet