1. Respiratory Effectiveness Group Study Proposal (REG) Insert name of Lead Investigator & key collaborating groups Please direct all questions and correspondence about this protocol to: [insert email address and contact details of Lead Investigator / corresponding collaborator]

2. Background Enter relevant text o Enter relevant text –Enter relevant text Enter relevant text o Enter relevant text –Enter relevant text Enter relevant text o Enter relevant text –Enter relevant text

3. Aims & Objectives Enter relevant text o Enter relevant text –Enter relevant text Enter relevant text o Enter relevant text –Enter relevant text Enter relevant text o Enter relevant text –Enter relevant text

4. Study design Enter relevant text o Enter relevant text –Enter relevant text Enter relevant text o Enter relevant text –Enter relevant text Enter relevant text o Enter relevant text –Enter relevant text

5. Methodology Enter relevant text o Enter relevant text –Enter relevant text Enter relevant text o Enter relevant text –Enter relevant text Enter relevant text o Enter relevant text –Enter relevant text

6. Study population Enter relevant text o Enter relevant text –Enter relevant text Enter relevant text o Enter relevant text –Enter relevant text Enter relevant text o Enter relevant text –Enter relevant text

7. Outcomes Enter relevant text o Enter relevant text –Enter relevant text Enter relevant text o Enter relevant text –Enter relevant text Enter relevant text o Enter relevant text –Enter relevant text

8. Study Team Research team o Enter relevant text –Enter relevant text Steering Committee involvement (if relevant) o Enter relevant text –Enter relevant text Patient Advocate involvement (if relevant) o Enter relevant text –Enter relevant text

9. Study Limitations & Ethics Enter details of known limitations of the planned study o Enter relevant text –Enter relevant text Enter details of any ethical approvals required for the study o Enter status of the current status of such approvals

10. Timelines Study o Estimated start date o Estimated completion date (include estimates of planned milestones and/or phases, where relevant) Dissemination plans o Enter details of publication plans –Enter estimated dates of publication plans