1. DEVICE FOR EXTRACORPORAL PURIFICATION OF BIOLOGICAL BODY FLUIDS FROM TOXINS BY APPLICATION OF MAGNETICALLY CONTROLLED MICROPARTICLES OF SORBENTS Danilin A.N., Zakharov A.P., Yanovskiy Yu.G. Institute of applied mechanics RAS, Moscow, e-mail: iam@ipsun.ras.ru Geydel А.А., Sidorin Yu.Yu. Scientific-production association “Nanometric powder materials - Kemerovo”, Kemerovo, e-mail: nano-psa@mail.ru Alehin A.I., Goncharov N.G. Central clinical hospital RAS, Moscow, e-mail: alehin.ckb@mail.ru Schematic diagram of the stand for investigating the detoxication processes of biological fluids by application of magnetically controlled sorbents 1 – tank, containing biological fluid with toxins; 2 – unit for preparing the suspension of magnetic sorbent; 3 – unit for mixing; 4 – peristaltic pump; 5 – magnetic filter; 6 – tank for collecting the biological fluid purified from toxins.

2. Version of magnetic filter design Creation of high-gradient magnetic fields 1, 2 – end bushings with inlet and outlet pipes; 3 – bushing for additional biasing of particles; 4 – bushing for rough filtration; 5 – bushing for precise filtration; 6 – bushing made of magnetically soft material; 7 – plastic insert in the area of precise filtration with spiral canals on its outer surface in order to arrange the flow of magnetic fluid crosswise the magnetic field lines.

3. Axial section of diametrically magnetized bushing of the first stage of magnetic separator Versions of bushing magnetization of precise filtration area of separator in order to create high-gradient magnetic fields (0.3-1.0 tesla/cm) Monolithic magnetic bushings (niodim-ferrum-boron), creating high-gradient magnetic fields

4. Structural versions of mixer-reactor Mixer-reactor. Assembled view Spiral canals Insert Housing Right and left caps (side pieces) with branch pipes Labyrinth mixer

5. Peristaltic pump Mixer Ultrasonic disperser Dosing pump N N N Main pipe N N N N S S Magnetic filter S S N N N N S S Multipole bushing of separation area Diametrically magnetized bushing of aggregation zone S N Functional scheme of the device for purification of biological body fluids from toxins and viruses by application of nano- and micro- particles of magnetically controlled sorbents Development, magnetic sorbents, testing: IAM RAS, PSA «NPM-КЕМЕRОVО», CCH RAS - medium to be purified (blood) - toxins and viruses - micro particles of magnetically controlled sorbent

6. Schematic diagram of the device for extracorporal detoxication of biological body fluids by application of micro-dimension magnetically controlled sorbents 2 - peristaltic pumps from the vein Ultrasonic sensor of air presence Solution of anticoagulant (heparin) to the vein 3 - mixer-reactor 4 – magnetic trap Air trap Ultrasonic level sensor Control, monitoring and supply unit Ultrasonic radiator 1- Ultrasonic unit for dispersion of suspension of magnetically controlled components Suspension “concentrate” in syringe

7. Experimental model of the device for detoxication of biological body fluids by application of magnetically controlled sorbents DEVICE FOR EXTRACORPORAL DETOXICATION OF BIOLOGICAL BODY FLUIDS

8. Investigation of sorption capacity of particles and their microstructure Optical density, relative units Wave length, nm Fig.9. Absorption spectrums of methylene blue in physiological solution (pH 7,2) at control (1), after adsorption by ferrocarbon (FC) for mass ratios of FC/adsorbate: 20 (2), 30 (3), 50 (4) Wave length, nm Fig.10. Absorption spectrums of cyanocobalamin (vitamin B 12 ) in physiological solution (pH 7,2) at control (1), after adsorption by ferrocarbon (FC) for mass ratios of FC/adsorbate: 20 (2), 30 (3), 50 (4) Fig.11. Absorption spectrums of hemoglobin in physiological solution (pH 7,2) at control (1), after adsorption by ferrocarbon (FC) for mass ratios of FC/adsorbate: 20 (2), 30 (3), 50 (4)