1. Silver-haired Bat (Lasionycteris noctivagans) Vector of cryptic rabies virus 1990-2002: ~70% of 33 reported human rabies cases in the US Only 2 cases had a history of bat bite

2. Plant System For High-Yield Production of Recombinant Subunit Vaccines

3.  Safety  Cost-efficiency  Easy scale-up  Proper glycosylation  Suitable for developing countries  Possible direct delivery Vaccine Production in Plants

4. RABIES VIRUS NEUTRALIZING TITERS OF HUMAN SERA CONTROL EXPERIMENTAL

5. BIOMEDICALS FOR DISEASE PROPHYLAXIS AND TREATMENT EXPRESSED IN PLANTS AT THE BIOTECHNOLOGY FOUNDATION LABORATORIES DISEASESPLANT VACCINEAntibody Severe Acute Respiratory Syndrome (SARS) Anthrax Respiratory Syncytial Virus (RSV) Smallpox Diphtheria, Pertussis, Tetanus (DPT) Rabies HIV Avian Influenza Hepatitis B Colorectal and Breast Cancer Tobacco Tomato Cauliflower Tobacco Tomato Spinach Tobacco Swiss Chard Collard Swiss Chard Carrot Tobacco Spinach Collard Tobacco Spinach Barley Lettuce Cauliflower Tobacco ● (recently initiated) ● ●●●●●●

6. COMPARATIVE COSTS OF ANTI-RABIES ANTIBODIES COMPANY PRODUCTPRODUCT DESCRIPTION PRODUCT PRICE NAME SOURCE Bayer BayRabHumanhuman anti-Rabies 1500 iu $1,125. Donorsimmunoglobulins Aventis IMOGAM Human anti-Rabies 1500 iu $ 847. Rabies-HTDonorsimmunoglobulins wholesale (10-18% protein) price AbCam ab10014Mouse monoclonal mouse100 µg $ 250. Cellsantibodies Biotechnology MAb57Tobacco monoclonal mouse 100 µg $ 0.5 -$1. Foundation, Inc.