1. Changes of Presenile Cataracts that had been Operated over 10 years in Korea Sung Kun Chung, M.D. ; Eun-Jung Jun, M.D. Hyun Seung Kim. Department of Ophthalmology and Visual Science, The Catholic University of Korea No author has any financial or proprietary interest in any materials or methods mentioned

2. Introduction Many studies about senile cataract Many studies about senile cataract : aged more than 60 years old : aged more than 60 years old : age is one of the most important risk factors of cataract : age is one of the most important risk factors of cataract Presenile cataract patients may display different characteristics from senile cataract patients Presenile cataract patients may display different characteristics from senile cataract patients Purpose To investigate the long-term characteristics and changes of presenile cataracts that had been operated in Korea. To investigate the long-term characteristics and changes of presenile cataracts that had been operated in Korea.

3. Materials & Methods Inclusion criteria Inclusion criteria ① aged from 30 to 50 years ① aged from 30 to 50 years ② underwent cataract surgeries at St. Mary’s hospital from 1995 to 2004(n=976) ② underwent cataract surgeries at St. Mary’s hospital from 1995 to 2004(n=976) Exclusion criteria Exclusion criteria ① patients with histories of ocular trauma or uveitis ① patients with histories of ocular trauma or uveitis ② those received combined surgeries ② those received combined surgeries Retrospective review of medical records Retrospective review of medical records Analyze Analyze ① age & sex : 31-40, 41-50 group ① age & sex : 31-40, 41-50 group ② their histories of diabetes and hypertension ② their histories of diabetes and hypertension ③ types of lens opacities ③ types of lens opacities ④ preoperative and postoperative visual acuities ④ preoperative and postoperative visual acuities Lens opacity grading : LOCS ⅢLens opacity grading : LOCS Ⅲ (Lens Opacity Classification System III) (Lens Opacity Classification System III) Statistical analysis Statistical analysis : Cochran-Armitage proportion trend test : Cochran-Armitage proportion trend test

4. Results 30-39 years40-49yearsTotal Mean age36.245.341.7 Male299(38.8%)472(61.2%)771(79.0%) Female81(39.5%)124(60.5%)205(21.0%) History of diabetes20(20.0)78(80.0)98(10.0%) History of hypertension16(21.1%)60(78.9%)76(7.8%)

5. Results

6. Results Anterior polar Opacity Posterior subcapsular opacity (PSCO) Anterior polar opacity +PSCO Cortical opacity Nuclear opacity 30-39years n (%) 147 (42.2%) 104 (30.3%) 34 (50%) 12 (20.3%) 16 (30.2%) 40-49years n (%) 201 (57.8%) 239 (69.7%) 34 (50%) 47 (79.7%) 37 (69.8%) Total n (%) 348 (35.7%) 343 (35.1%) 68 (7.0%) 59 (6.0%) 53 (5.4%) Lens opacities in each age group (LOCS Ⅲ )

7. Region of study Sample size, race Methods of evaluation Age Group (yrs) Prevalence(%) CorticalNuclearPSCMaleFemale Beijing, China 4439, Chinese slit-lamp c AREDS ≥ 40 0.382.24.3No statistically significant difference in gender Shih- Pai,Taiw an 1361, Chinese Slit-lamp c LOCS Ⅲ ≥ 65 21.938.99.2Female predominance Singapo re 1717, Chinese Slit-lamp c LOCS Ⅲ 40-7923.922.67.0No statistically significant difference in gender Sumatra, Indonesia 919, Indonesian Slit-lamp c LOCS Ⅲ ≥ 21 45.7Female predominance except cortical cat. Victoria, Australia 4433, Australian Slit-lamp c WCGS ≥ 40 11.312.64.08Female predominance Korea976, Korean Slit-lamp c LOCS Ⅲ 30-496.05.435.1Male predominanceResults *PSC : posterior subcapsular *c : with *AREDS : Age-related Eye disease Study *LOCS Ⅲ : Lens Opacities Classification System Ⅲ *cat. : cataract *JCCESG : Japanese Cooperative Cataract Epidemiology Study Group *WCGS : Wilmer cataract grading scheme

8. Results Eyes that had surgeries for presenile cataracts displayed statistically significant decrease(p = 0.0002, CI 95%) Eyes that had surgeries for presenile cataracts displayed statistically significant decrease(p = 0.0002, CI 95%) Presenile cataracts with diabetes showed no significant trend with the passage of time(p = 0.4767, CI 95%) Presenile cataracts with diabetes showed no significant trend with the passage of time(p = 0.4767, CI 95%) Presenile cataracts with hypertension showed statistically significant increase (p = 0.0049, CI 95%) Presenile cataracts with hypertension showed statistically significant increase (p = 0.0049, CI 95%)

9. Conclusion Presenile cataract patients had different characteristics from senile cataract patients. Presenile cataract patients had different characteristics from senile cataract patients. Men consisted of the majority of the presenile cataract patients. Men consisted of the majority of the presenile cataract patients. Anterior polar opacity was the most common type of lens opacity. Anterior polar opacity was the most common type of lens opacity. Cataracts with hypertension showed overall increase over 10 years. Cataracts with hypertension showed overall increase over 10 years.