1. Chapter 1. Applications of Synthetic Receptors for Biomolecules
Supplementary information for Synthetic Receptors for Biomolecules: Design Principles and Applications
© The Royal Society of Chemistry 2015
Chapter 1. Applications of Synthetic Receptors for Biomolecules
Evan M. Peck and Bradley D. Smith*
Department of Chemistry and Biochemistry,
236 Nieuwland Science Hall,
University of Notre Dame, Notre Dame, IN, USA *

2. © The Royal Society of Chemistry 2015
Supplementary information for Synthetic Receptors for Biomolecules: Design Principles and Applications
© The Royal Society of Chemistry 2015
Scheme 1.1 Receptor biomolecule association with 1:1 stoichiometry.

3. Scheme 1.2 Work flow diagram for supramolecular chemistry research.
Supplementary information for Synthetic Receptors for Biomolecules: Design Principles and Applications
© The Royal Society of Chemistry 2015
Scheme 1.2 Work flow diagram for supramolecular chemistry research.

4. Scheme 1.3 Major categories of synthetic receptors.
Supplementary information for Synthetic Receptors for Biomolecules: Design Principles and Applications
© The Royal Society of Chemistry 2015
Scheme 1.3 Major categories of synthetic receptors.

5. Scheme 1.4 Common scaffolds for organic molecular receptors.
Supplementary information for Synthetic Receptors for Biomolecules: Design Principles and Applications
© The Royal Society of Chemistry 2015
Scheme 1.4 Common scaffolds for organic molecular receptors.

6. Scheme 1.5 Receptor scaffolds that incorporate Lewis acids.
Supplementary information for Synthetic Receptors for Biomolecules: Design Principles and Applications
© The Royal Society of Chemistry 2015
Scheme 1.5 Receptor scaffolds that incorporate Lewis acids.

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Supplementary information for Synthetic Receptors for Biomolecules: Design Principles and Applications
© The Royal Society of Chemistry 2015
Scheme 1.6 X-ray structure of RNA aptamer complex with 5’-adenosine monophosphate (AMP) guest.

8. © The Royal Society of Chemistry 2015
Supplementary information for Synthetic Receptors for Biomolecules: Design Principles and Applications
© The Royal Society of Chemistry 2015
Scheme 1.7 Molecular imprinted polymer created by non-covalent imprinting.

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Supplementary information for Synthetic Receptors for Biomolecules: Design Principles and Applications
© The Royal Society of Chemistry 2015
Scheme 1.8 Guest encapsulation within the internal cavities of a dendrimer or hyperbranched polymer.

10. Scheme 1.9 Nanoparticle with core shell architecture.
Supplementary information for Synthetic Receptors for Biomolecules: Design Principles and Applications
© The Royal Society of Chemistry 2015
Scheme 1.9 Nanoparticle with core shell architecture.

11. Scheme 1.10 Major applications of receptors for biomolecules.
Supplementary information for Synthetic Receptors for Biomolecules: Design Principles and Applications
© The Royal Society of Chemistry 2015
Scheme 1.10 Major applications of receptors for biomolecules.

12. Scheme 1.11 Affinity chromatography involves three major steps.
Supplementary information for Synthetic Receptors for Biomolecules: Design Principles and Applications
© The Royal Society of Chemistry 2015
Scheme 1.11 Affinity chromatography involves three major steps.

13. Scheme 1.12 Synthetic receptors for separations.

14. Scheme 1.13 Liquid membrane transport.

15. Scheme 1.14 Supramolecular systems for imaging and sensing.
Supplementary information for Synthetic Receptors for Biomolecules: Design Principles and Applications
© The Royal Society of Chemistry 2015
Scheme 1.14 Supramolecular systems for imaging and sensing.

16. Scheme 1.15 Synthetic receptors used for imaging and sensing.
Supplementary information for Synthetic Receptors for Biomolecules: Design Principles and Applications
© The Royal Society of Chemistry 2015
Scheme 1.15 Synthetic receptors used for imaging and sensing.

17. Scheme 1.16 Supramolecular catalysis of ligation or cleavage reactions.

18. Scheme 1.17 Synthetic pyridoxamine dendrimer as transaminase mimic.

19. Scheme 1.18 Synthetic receptors for catalysis.

20. © The Royal Society of Chemistry 2015
Supplementary information for Synthetic Receptors for Biomolecules: Design Principles and Applications
© The Royal Society of Chemistry 2015
Scheme 1.19 Pharmaceutically relevant protein biomolecule association systems.

21. Scheme 1.20 Synthetic receptors with pharmaceutical activity.
Supplementary information for Synthetic Receptors for Biomolecules: Design Principles and Applications
© The Royal Society of Chemistry 2015
Scheme 1.20 Synthetic receptors with pharmaceutical activity.

22. Scheme 1.21 Channel and carrier mechanisms for membrane transport.
Supplementary information for Synthetic Receptors for Biomolecules: Design Principles and Applications
© The Royal Society of Chemistry 2015
Scheme 1.21 Channel and carrier mechanisms for membrane transport.