1. TOMHS 8.3% 6.8% 18.3% 2.8% 6.6% 6.8%

2. Treatment of Mild Hypertension Study (TOMHS) Eligibility Visits 902 men/women Age 45-69 years DBP 90-99 mm Hg Free of CHD Drug/withdrawal visits Randomization by Stratum 1 Stratum 2 Weight loss, sodium reduction, alcohol reduction, increased physical activity Placebo n = 234 Beta Blocker Acebutolol n = 132 400-800 mg Ca Blocker Amlodipine n = 131 5-10 mg Diuretic Chlorthalidone n = 136 15-30 mg Alpha blocker Doxazosin n = 134 2-4 mg ACE Inhibitor Enalapril n = 135 5-10 mg

3. TOMHS Male Participants Reporting Difficulty Obtaining Erection: Baseline to 24 Months Percent Number of participants: 83 62 73 70 62 125 ANOVA P =.20

4. TOMHS Male Participants Reporting Difficulty Obtaining Erection 24 and 48 Months by Treatment Group * *P <.04 vs placebo

6. ALLHAT

7. ALLHAT

8. ALLHAT