1. LUNG TRANSPLANTATION Pediatric Recipients ISHLT 2012 J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

2. RECIPIENT AGE DISTRIBUTION FOR PEDIATRIC LUNG RECIPIENTS - NUMBER (Transplants: January 1986 - June 2011) ISHLT 2012 Analysis includes living donor transplants J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

3. RECIPIENT AGE DISTRIBUTION FOR PEDIATRIC LUNG RECIPIENTS – PERCENTAGE (Transplants: January 1986 - June 2011) ISHLT 2012 Analysis includes living donor transplants J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

4. DONOR TYPE DISTRIBUTION BY YEAR OF TRANSPLANT FOR PEDIATRIC LUNG RECIPIENTS (Transplants: 1986-2010) ISHLT 2012 NOTE: This figure includes only the lung transplants that are reported to the ISHLT Transplant Registry. As such, the presented data may not mirror the changes in the number of lung transplants performed worldwide. Analysis includes living donor transplants J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

5. DONOR TYPE DISTRIBUTION BY RECIPIENT AGE GROUP WITHIN ERA FOR PEDIATRIC LUNG RECIPIENTS (Transplants: January 1986 – June 2011) ISHLT 2012 Analysis includes living donor transplants J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

6. AGE DISTRIBUTION FOR DONORS OF PEDIATRIC LUNG RECIPIENTS (Transplants: January 1986 - June 2011) ISHLT 2012 J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

7. AGE DISTRIBUTION OF PEDIATRIC LUNG RECIPIENTS BY YEAR OF TRANSPLANT ISHLT 2012 NOTE: This figure includes only the pediatric lung transplants that are reported to the ISHLT Transplant Registry. Therefore, these numbers should not be interpreted as the rate of change in pediatric lung procedures performed worldwide. Analysis includes living donor transplants J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

8. NUMBER OF CENTERS REPORTING PEDIATRIC LUNG TRANSPLANTS ISHLT 2012 Analysis includes living donor transplants J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

9. NUMBER OF CENTERS REPORTING PEDIATRIC LUNG TRANSPLANTS BY CENTER VOLUME ISHLT 2012 Analysis includes living donor transplants J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

10. NUMBER OF PEDIATRIC LUNG TRANSPLANTS BY CENTER VOLUME ISHLT 2012 Analysis includes living donor transplants J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

11. PEDIATRIC LUNG TRANSPLANTS: Indications (Transplants: January 1990 - June 2011) ISHLT 2012 Diagnosis AGE: < 1 Year AGE: 1-5 Years AGE: 6-11 Years AGE: 12-17 Years Cystic Fibrosis 11.1%65.0%17153.8%82671.5% Idiopathic Pulmonary Arterial Hypertension 1213.2%2722.5%319.7%837.2% Re-Transplant: Obliterative Bronchiolitis 75.8%92.8%353.0% Congenital Heart Disease 1415.4%97.5%41.3%100.9% Idiopathic Pulmonary Fibrosis 99.9%2117.5%154.7%393.4% Obliterative Bronchiolitis (Not Re-TX) 108.3%237.2%494.2% Re-Transplant: Not OB 33.3%4 92.8%302.6% Interstitial Pneumonitis 11.1%21.7%30.9% Pulmonary Vascular Disease 88.8%75.8%41.3%10.1% Eisenmenger’s Syndrome 11.1%54.2%51.6%70.6% Pulmonary Fibrosis, Other 66.6%86.7%165.0%242.1% Surfactant Protein B Deficiency 1617.6%32.5% COPD/Emphysema 44.4%21.7%30.9%90.8% Bronchopulmonary Dysplasia 33.3%32.5%72.2%20.2% Bronchiectasis 11.1% 61.9%141.2% Other 1213.2%65.0%123.8%272.3% Analysis includes living donor transplants J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

12. DIAGNOSIS IN PEDIATRIC LUNG RECIPIENTS BY YEAR OF TRANSPLANT Age: 12-17 Years ISHLT 2012 Analysis includes living donor transplants J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

13. PEDIATRIC LUNG TRANSPLANTS Age Distribution by Location ( Transplants: January 2000 – June 2011) ISHLT 2012 Analysis includes living donor transplants J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

14. PEDIATRIC LUNG TRANSPLANTS Diagnosis Distribution by Location (Transplants: January 2000 – June 2011) ISHLT 2012 Analysis includes living donor transplants NOTE: Unknown diagnoses were excluded from this tabulation Total number of transplants reported: Europe = 410 North America = 619 Other = 66 J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

15. PEDIATRIC LUNG TRANSPLANTS Donor Age Distribution by Location (Transplants: January 2000 – June 2011) ISHLT 2012 NOTE: Transplants with unknown donor age and living donor transplants were excluded from this tabulation. Total number of transplants reported: Europe = 410 North America = 619 Other = 66 J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

16. LUNG TRANSPLANTS Kaplan-Meier Survival by Recipient Age Group (Transplants: January 1990 - June 2010) ISHLT 2012 p = 0.4368 J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

17. PEDIATRIC LUNG TRANSPLANTS Kaplan-Meier Survival by Procedure Type (Transplants: January 1990 - June 2010) ISHLT 2012 p < 0.0001 J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

18. PEDIATRIC LUNG TRANSPLANTS Kaplan-Meier Survival for Congenital Diagnoses (Transplants: January 1990 - June 2010) ISHLT 2012 Eisenmenger’s vs. Other: p = 0.5078 J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

19. PEDIATRIC LUNG TRANSPLANTS Kaplan-Meier Survival by Recipient Age Group (Transplants: January 1990 - June 2010) ISHLT 2012 <1 year vs. 1-11 years: p = 0.2101 <1 year vs. 12-17 years: p = 0.9694 1-11 years vs. 12-17 years: p = 0.0106 J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

20. PEDIATRIC LUNG TRANSPLANTS Conditional Kaplan-Meier Survival by Recipient Age Group (Transplants: January 1990 - June 2010) ISHLT 2012 <1 year vs. 1-11 years: p = 0.7629 <1 year vs. 12-17 years: p = 0.1241 1-11 years vs. 12-17 years: p = 0.0083 J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

21. PEDIATRIC LUNG TRANSPLANTS Kaplan-Meier Survival by Era (Transplants: January 1988 - June 2010) ISHLT 2012 1988-1994 vs. 1995-2001: p = 0.0556 1988-1994 vs. 2002-6/2010: p < 0.0001 1995-2001 vs. 2002-6/2010: p = 0.0033 J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

22. PEDIATRIC LUNG TRANSPLANTS Kaplan-Meier Survival by Donor Type for Recipients Age 12-17 Years (Transplants: January 1990 - June 2010) ISHLT 2012 p = 0.2897 J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

23. PEDIATRIC LUNG RE-TRANSPLANTS Between January 1994 and June 2011 ISHLT 2012 Analysis includes living donor transplants J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

24. PEDIATRIC LUNG RE-TRANSPLANTS Survival for Transplants Performed Between January 1994 and June 2010 ISHLT 2012 J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

25. PEDIATRIC LUNG RE-TRANSPLANTS Survival for Transplants Performed Between January 1988 and June 2010 Stratified by Inter-Transplant Interval ISHLT 2012 Analysis includes living donor transplants. Only patients who were less than 18 years old at the time of re- transplant are included. J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

26. PEDIATRIC LUNG RE-TRANSPLANTS Survival for Transplants Performed Between January 1988 and June 2010 Stratified by Diagnosis ISHLT 2012 Analysis includes living donor transplants. Only patients who were less than 18 years old at the time of re- transplant are included. J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

27. PEDIATRIC LUNG RECIPIENTS Cross-Sectional Analysis Functional Status of Surviving Recipients (Follow-ups: April 1994 – June 2011) ISHLT 2012 J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

28. PEDIATRIC LUNG RECIPIENTS Functional Status of Surviving Recipients US Recipients Only (Follow-ups: March 2005 – June 2011) ISHLT 2012 J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

29. PEDIATRIC LUNG RECIPIENTS Rehospitalization Post-transplant of Surviving Recipients (Follow-ups: April 1994 – June 2011) ISHLT 2012 J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

30. PEDIATRIC LUNG RECIPIENTS Rehospitalization Post-transplant of Surviving Recipients (Follow-ups: April 1994 – June 2011) ISHLT 2012 J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

31. PEDIATRIC LUNG RECIPIENTS Induction Immunosuppression (T ransplants: January 2001 – June 2011) ISHLT 2012 Analysis is limited to patients who were alive at the time of the discharge J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

32. PEDIATRIC LUNG RECIPIENTS Induction Immunosuppression (Transplants: January 2001 – June 30, 2011) ISHLT 2012 Analysis is limited to patients who were alive at the time of the discharge J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

33. PEDIATRIC LUNG TRANSPLANTS Kaplan-Meier Survival Stratified by Induction Use (Transplants: January 2001 - June 2010) ISHLT 2012 p = 0.8790 J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

34. PEDIATRIC LUNG RECIPIENTS Maintenance Immunosuppression at Time of Follow-up (Follow-ups: January 2001 – June 2011) ISHLT 2012 Analysis is limited to patients who were alive at the time of the follow-up J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

35. PEDIATRIC LUNG RECIPIENTS Maintenance Immunosuppression at Time of Follow-up (Follow-ups: January 2001 – June 2011) ISHLT 2012 Analysis is limited to patients who were alive at the time of the follow-up NOTE: 0.2% of patients were on both calcineurin inhibitors at different point during the 1-year; these patients are not counted in either group. And 0.5% (2 patients) was on neither drug during the 1-year. In the 5-year tabulations, 0.6% were reported to be on both drugs during the year and 1.7% (3 patients) was reported to be on neither drugs. J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

36. PEDIATRIC LUNG RECIPIENTS Maintenance Immunosuppression Drug Combinations at Time of Follow-up (Follow-ups: January 2001 – June 2011) ISHLT 2012 Analysis is limited to patients who were alive at the time of the follow-up NOTE: Different patients are analyzed in Year 1 and Year 5 J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

37. POST-LUNG TRANSPLANT MORBIDITY FOR PEDIATRICS Cumulative Morbidity Rates in Survivors within 1 Year Post- Transplant (Follow-ups: April 1994 - June 2011) ISHLT 2012 Outcome Within 1 Year Total number with known response Hypertension41.7%(N = 664) Renal Dysfunction10.0%(N = 683) Abnormal Creatinine < 2.5 mg/dl6.9% Creatinine > 2.5 mg/dl2.0% Chronic Dialysis0.7% Renal Transplant0.3% Hyperlipidemia5.1%(N = 683) Diabetes23.5%(N = 684) Bronchiolitis Obliterans Syndrome13.2%(N = 638) J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

38. POST-LUNG TRANSPLANT MORBIDITY FOR PEDIATRICS Cumulative Morbidity Rates in Survivors within 5 Years Post- Transplant (Follow-ups: April 1994 - June 2011) ISHLT 2012 Outcome Within 5 Years Total number with known response Hypertension69.8%(N = 179) Renal Dysfunction32.8%(N = 189) Abnormal Creatinine < 2.5 mg/dl24.3% Creatinine > 2.5 mg/dl5.3% Chronic Dialysis1.6% Renal Transplant1.6% Hyperlipidemia15.8%(N = 184) Diabetes36.8%(N = 190) Bronchiolitis Obliterans Syndrome35.9%(N = 145) J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

39. POST-LUNG TRANSPLANT MORBIDITY FOR PEDIATRICS Cumulative Morbidity Rates in Survivors within 7 Years Post- Transplant (Follow-ups: April 1994 - June 2011) ISHLT 2012 Outcome Within 7 Years Total number with known response Renal Dysfunction41.3%(N = 92) Abnormal Creatinine < 2.5 mg/dl29.3% Creatinine > 2.5 mg/dl7.6% Chronic Dialysis0.0% Renal Transplant4.3% Diabetes33.9%(N = 62) Bronchiolitis Obliterans Syndrome44.6%(N = 56) J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

40. Freedom from Bronchiolitis Obliterans Syndrome For Pediatric Lung Recipients (Follow-ups: April 1994-June 2011) ISHLT 2012 J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

41. Freedom from Bronchiolitis Obliterans Syndrome For Pediatric Lung Recipients by Age Group (Follow-ups: April 1994-June 2011) ISHLT 2012 p = 0.0308 J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

42. Freedom from Bronchiolitis Obliterans Syndrome For Pediatric Lung Recipients by Diagnosis (Follow-ups: April 1994-June 2011) ISHLT 2012 p = 0.0606 J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

43. Freedom from Bronchiolitis Obliterans Syndrome For Pediatric Lung Recipients by Induction Use (Follow-ups: April 1994-June 2011) ISHLT 2012 p = 0.9867 J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

44. Freedom from Severe Renal Dysfunction* For Pediatric Lung Recipients (Follow-ups: April 1994-June 2011) ISHLT 2012 J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

45. MALIGNANCY POST-LUNG TRANSPLANT FOR PEDIATRICS Cumulative Morbidity Rates in Survivors (Follow-ups: April 1994-June 2011) ISHLT 2012 Malignancy/Type 1-Year Survivors 5-Year Survivors 7-Year Survivors No Malignancy 657 (94.4%)175 (88.8%)87 (90.6%) Malignancy (all types combined) 39 (5.6%)22 (11.2%)9 (9.4%) Malignancy Type* Lymphoma 36229 Other 210 Type Not Reported 100 * Recipients may have experienced more than one type of malignancy so sum of individual malignancy types may be greater than total number with malignancy. ”Other” includes Liver and primitive neuroectodermal tumor. J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

46. Freedom from Malignancy For Pediatric Lung Recipients (Follow-ups: April 1994- June 2011) ISHLT 2012 J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

47. PEDIATRIC LUNG TRANSPLANT RECIPIENTS Cause of Death (Deaths: January 1992 - June 2011) ISHLT 2012 CAUSE OF DEATH 0-30 Days (N =114) 31 Days - 1 Year (N = 159) >1 Year - 3 Years (N = 209) >3 Years - 5 Years (N = 92) >5 Years (N = 84) BRONCHIOLITIS 16 (10.1%)80 (38.3%)36 (39.1%)38 (45.2%) ACUTE REJECTION 3 (2.6%)3 (1.9%)2 (1.0%)2 (2.2%) LYMPHOMA 8 (5.0%)7 (3.3%)4 (4.3%)5 (6.0%) MALIGNANCY, NON-LYMPHOMA 1 (0.6%)1 (0.5%) 3 (3.6%) CMV 5 (3.1%) INFECTION, NON-CMV 15 (13.2%)53 (33.3%)32 (15.3%)18 (19.6%)9 (10.7%) GRAFT FAILURE 35 (30.7%)31 (19.5%)49 (23.4%)20 (21.7%)17 (20.2%) CARDIOVASCULAR 18 (15.8%)6 (3.8%)3 (1.4%)1 (1.1%) TECHNICAL 13 (11.4%)5 (3.1%)6 (2.9%)3 (3.3%)1 (1.2%) MULTIPLE ORGAN FAILURE 11 (9.6%)19 (11.9%)10 (4.8%)3 (3.3%)6 (7.1%) OTHER 19 (16.7%)12 (7.5%)19 (9.1%)5 (5.4%)5 (6.0%) J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

48. PEDIATRIC LUNG TRANSPLANT RECIPIENTS Relative Incidence of Leading Causes of Death (Deaths: January 1992 - June 2011) ISHLT 2012 J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

49. PEDIATRIC LUNG TRANSPLANT RECIPIENTS (1/1993-6/2010) Risk Factors For 1 Year Mortality/Graft Failure ISHLT 2012 VARIABLENRelative Risk P-value95% Confidence Interval Single lung transplant 113.920.0021.63 -9.41 On ventilator 1333.17<.00012.10 -4.77 Year of transplant: 1993-2000 vs. 2001-6/2010 3371.670.0021.21 -2.31 Donor CMV+/Recipient CMV- 2621.400.0341.03 -1.91 Chronic steroid use 2991.330.0850.96 -1.84 N = 826 J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

50. PEDIATRIC LUNG TRANSPLANT RECIPIENTS (1/1993-6/2010) Risk Factors For 1 Year Mortality/Graft Failure ISHLT 2012 Continuous Factors (see figures) Pediatric transplant center volume (borderline) J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

51. PEDIATRIC LUNG TRANSPLANT RECIPIENTS (1/1993-6/2010) Risk Factors For 1 Year Mortality/Graft Failure Center Volume Pediatric Transplants ISHLT 2012 p = 0.0870 J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

52. PEDIATRIC LUNG TRANSPLANT RECIPIENTS (1/1993-6/2006) Risk Factors For 5 Year Mortality/Graft Failure ISHLT 2012 VARIABLENRelative Risk P-value95% Confidence Interval Single lung transplant 94.370.00012.07 -9.21 On ventilator 911.980.00041.36 -2.89 Chronic steroid use 2141.320.02081.04 -1.66 Year of transplant: 1993-2000 vs. 2001-6/2006 3371.300.03041.02 -1.64 N = 609 J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

53. PEDIATRIC LUNG TRANSPLANT RECIPIENTS (1/1993-6/2006) Risk Factors For 5 Year Mortality/Graft Failure ISHLT 2012 Continuous Factors (see figures) Recipient age Pediatric transplant center volume J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

54. PEDIATRIC LUNG TRANSPLANT RECIPIENTS (1/1993-6/2006) Risk Factors For 5 Year Mortality/Graft Failure Recipient Age ISHLT 2012 p = 0.0424 J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

55. PEDIATRIC LUNG TRANSPLANT RECIPIENTS (1/1993-6/2006) Risk Factors For 5 Year Mortality/Graft Failure Center Volume Pediatric Transplants ISHLT 2012 p = 0.0075 J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

56. PEDIATRIC LUNG TRANSPLANT RECIPIENTS (1/1991-6/2001) Risk Factors For 10 Year Mortality/Graft Failure ISHLT 2012 VARIABLENRelative Risk P-value95% Confidence Interval On ventilator 652.17<.00011.49 -3.15 Single lung transplant 242.110.01221.18 -3.78 Donor cause of death = anoxia 361.450.07400.96 -2.17 N = 369 J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

57. PEDIATRIC LUNG TRANSPLANT RECIPIENTS (1/1991-6/2001) Risk Factors For 10 Year Mortality/Graft Failure ISHLT 2012 Continuous Factors (see figures) Recipient age Pediatric transplant center volume (borderline) J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

58. PEDIATRIC LUNG TRANSPLANT RECIPIENTS (1/1991-6/2001) Risk Factors For 10 Year Mortality/Graft Failure Recipient Age ISHLT 2012 p = 0.0195 J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095

59. PEDIATRIC LUNG TRANSPLANT RECIPIENTS (1/1991-6/2001) Risk Factors For 10 Year Mortality/Graft Failure Center Volume Pediatric Transplants ISHLT 2012 p = 0.0896 J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095