1. Microvascular Complications in Childhood- Onset Type 1 Diabetes and Celiac Disease: A Multicenter Longitudinal Analysis of 56,514 Patients From the German-Austrian DPV Database Featured Article: Tilman R. Rohrer, Johannes Wolf, Susanne Liptay, Klaus-Peter Zimmer, Elke Fröhlich-Reiterer, Nicole Scheuing, Wolfgang Marg, Martin Stern, Thomas M. Kapellen, Berthold P. Hauffa, Joachim Wölfle, and Reinhard W. Holl, for the DPV Initiative and the German BMBF Competence Network Diabetes Mellitus Diabetes Care Volume 38: 801-807 May, 2015

2. STUDY OBJECTIVE To investigate whether celiac disease (CD) associated with type 1 diabetes increases the risk of microvascular complications Rohrer T. R. et al. Diabetes Care 2015;38:801-807

3. STUDY DESIGN AND METHODS Patients aged >10 years with diabetes duration <20 years from 392 centers in Germany and Austria were assigned to one of three categories: No CD Biopsy-confirmed CD Suspected CD Confirmed and suspected groups were combined and analyzed for retinopathy or nephropathy Cox proportional hazards regression was used to adjust for potential confounders Rohrer T. R. et al. Diabetes Care 2015;38:801-807

4. RESULTS Kaplan-Meier analysis revealed that retinopathy and nephropathy occurred earlier in the presence versus absence of CD Adjusted risk for both retinopathy and nephropathy was higher in patients with diabetes and CD versus patients without CD Cox regression revealed CD as an independent risk factor for microvascular complications after adjusting for confounders Rohrer T. R. et al. Diabetes Care 2015;38:801-807

7. CONCLUSIONS CD is an independent risk factor for retinopathy and nephropathy in patients with type 1 diabetes Regular serologic testing for CD is recommended, even in the absence of clinical CD Further studies are needed to determine if a gluten-free diet reduces the risk of microvascular disorders in patients with diabetes and CD Rohrer T. R. et al. Diabetes Care 2015;38:801-807