1. Immune System Review Book Fold a blank piece of paper into 8 rectangles, then cut them apart. Staple the pages together to make a booklet. staples Immune System Review Book The purpose of the book is to give you an overview/summary of the Immune system. Use it to help you study!

2. Immune System Review Book By: _________________ Cover of book:

3. Inside cover (first pages) The Three Lines of Defense: 1.Surface Barriers 2.Nonspecific Response 3.Specific Response 1. Surface Barriers Skin Tears Mucous Membranes Saliva Cough &Sneeze Friendly Bacteria Low pH Urine Diarrhea Left side right side

4. Next pages 2.Non-specific Response Complement Proteins: Can interact with carb molecules on the surfaces of microorganisms Cascade Lysis Reactions to make protein “membrane attack complexes” Attack complexes insert into cell membrane and lyse microorganism (death)

5. Next Pages (I’m sorry I forgot these in class Wednesday! You can add them to the end of your booklet if it is too hard to insert them) 2. Inflammatory Response— also non-specific a. Bacteria invade b. Tissue irritation causes mast cells to release histamine (shown here as red dots) c. Capillary walls become leaky. Fluid and complement proteins leak out. Swelling. d. Complement proteins attack bacteria e. Phagocytes engulf invaders

6. Next pages 3.Specific Response Antigen triggers formation of lymphocyte armies. T and B lymphocytes will specifically recognize FOREIGN antigens. T and B will divide repeatedly into effector and memory cells. Our own cells recognize each other. Cells have MHC markers designating “self.” antigen on surface of bacterial cell antigen on surface of virus

7. Next pages 3. “T” Cell Mediated Response a. Macrophages ingest virus particles. Virus antigens are not digested, ANTIGEN IS DISPLAYED IN MHC COMPLEX Antigen-MHC Complex b.T cell Receptor of Helper T cells recognize the specific MHC-antigen complex. Binding stimulates the macrophage to secrete interleukins. c.Helper T releases interleukin 2. d.Interleukin 2 stimulates cell division of effector cytotoxic T armies Effector cytotoxic T: What does cytotoxic T do?

8. Next pages 3.Antibody-mediated response (B cells) Antibody: Effector Cytotoxic T cells find body cells infected with the virus (virus antigen presented in antigen-MHC complex). They “touch kill” cells with perforins. touch-killed body cell effector cytotoxic T cell antigen-MHC complex on infected body cell antigen-binding sites

9. last pages B cell armies are made Effector B cells Make/secrete many antibodies Memory B cells are made, too 3. Antibody-mediated response B cell encounters unbound Antigen from bacteria. Receptors bind antigen. Antigen is displayed in MHC. Helper T binds to antigen-MHC. Interleukins are released. Interleukins trigger cell division: B cell armies are made.