1. Corporate Office of Science and Technology © Copyright Johnson & Johnson 2004 Nanotechnology Applications in Health Care World Environment Center Nanotech Roundtable New York, NY March 11, 2005 Youseph Yazdi, Ph.D. Corporate Director, Science and Technology

2. Health Care Applications of Nanotechnology WEC Nanotech Rountable NY | March 11, 2005 | Y. Yazdi, Ph.D.1 World’s Largest Comprehensive Health Care Company… Medical Device and Diagnostics Consumer Products Pharmaceutical $8.3 ($0.31) $16.9 ($2.2) $22.1 ($3.5) AVEENO

3. Health Care Applications of Nanotechnology WEC Nanotech Rountable NY | March 11, 2005 | Y. Yazdi, Ph.D.2 Corporate Office of Science & Technology: Collaboration Hub Medical Device and Diagnostics Consumer Products Pharmaceutical AVEENO Promote Collaboration Promote Innovation Develop New Businesses

4. Health Care Applications of Nanotechnology WEC Nanotech Rountable NY | March 11, 2005 | Y. Yazdi, Ph.D.3 Nanotechnology in Nature: Our Design and Proof-of-Principle Lab Spider silk is 100 times stronger than steel per unit weight Bacterial flagellar motors convert energy with near 100% efficiency. Typical auto engine is ~30% efficient trillion neurons self-assemble to form 10 16 contacts, ten orders of magnitude greater contact density than on a Pentium chip Source: Larry Bock, Nanosys, Inc. Nature is not biased to what humans can see and manipulate -- it is optimized on all scales

5. Health Care Applications of Nanotechnology WEC Nanotech Rountable NY | March 11, 2005 | Y. Yazdi, Ph.D.4 From nature to nanotech: now we are in the game… “nano is the scale of light, the scale of life”

6. Health Care Applications of Nanotechnology WEC Nanotech Rountable NY | March 11, 2005 | Y. Yazdi, Ph.D.5 Most significant development: nanotech “picks & shovels”  Nanoscale imaging, characterization, modeling, simulation, prototyping tools  “you can’t go where to can’t see…” -Microscope --> Lister theory of microbial basis of disease --> J&J’s first products, antiseptic bandages -How will aM and zM detection of PSA, HIV, effect clinical disease management --> we can’t know until we can see it!

7. Health Care Applications of Nanotechnology WEC Nanotech Rountable NY | March 11, 2005 | Y. Yazdi, Ph.D.6 Biggest Hurdle: Hype (negative or positive) 1988: Drexler “Engines of Creation”  Negative: ‘grey goo’, M. Creighton, MD, HRH Prof Prince Charles, Bill Joy…  ‘Positive’: Fantastic Voyage… ?! 1985: Smalley, Curl, Rice U. (go Owls!) discover shape of C-60

8. Health Care Applications of Nanotechnology WEC Nanotech Rountable NY | March 11, 2005 | Y. Yazdi, Ph.D.7 Not just the lay press…Reading past the nano “A nanomolecular approach to the nanofabrication of nanoparticles using a nanooptical nanochemical nanobioreactor” [ref: Bogus Journal, October 2004]

9. Health Care Applications of Nanotechnology WEC Nanotech Rountable NY | March 11, 2005 | Y. Yazdi, Ph.D.8  Tissue Engineering: -scaffolds to promote tissue growth -tissue engineering of bone, cartilage, skin, arteries, nerves  Nanocomposites: -improved mechanical properties for orthopedic and other implants  Coatings for Implants: -improve osteointegration, faster fixation  Diagnostics: -identifying and quantifying rare events -evaluating the impact of anti-cancer agents in treatment and clinical trials  Tissue Ablation: -technologies for localized tumor ablation -targeting for minimal collateral damage Current Some Key Opportunity Spaces for Medical Device Apps of Nanotech

10. Health Care Applications of Nanotechnology WEC Nanotech Rountable NY | March 11, 2005 | Y. Yazdi, Ph.D.9 Some Key Opportunity Spaces for Pharma Apps of Nanotech  Drug Delivery -nanocapsules, liposomes, targeted delivery  Tools for Drug Discovery and Drug Development -micro and nano fluidics -biomarkers & bar codes -nano-milling for solubility/stabilization  Multifunctional Therapeutics: Combining… -targeting -recognition -drug release -monitoring  Supramolecular Drug Design -self-assembly in targeted manner -synthetic peptides

11. Health Care Applications of Nanotechnology WEC Nanotech Rountable NY | March 11, 2005 | Y. Yazdi, Ph.D.10 Key Opportunity Spaces in Nanotech for Consumer Products  Improved Materials -responsive to physical or chemical changes -improved moisture and thermal handling properties  Improved Adhesives -based on physical (vs chemical) properties of materials -self-cleaning, more versatile  Nanodispersives -for delivery of therapeutic agents -increased bioavailability of active ingredients  Cosmetics -improved wear-resistance -change in response to environment  Consumer Diagnostics

12. Health Care Applications of Nanotechnology WEC Nanotech Rountable NY | March 11, 2005 | Y. Yazdi, Ph.D.11  ALZA -broad range of expertise and capabilities in key areas of nanotechnology -product interests: drug delivery, drug formulation  Center Biomaterials and Adv Tech (CBAT) -Implantable biomaterials -Drug-device combinations -Tissue Engineering Scaffolds -Drug Delivery technologies -Microspheres and Microdispersives  JJ Medical Microsystems -newly formed center for MEMS R&D -focus on select product development efforts The Stealth Liposome. ALZA Internal Johnson & Johnson Nanotech and MEMS Expertise Cells Scaffold Scaffold to promote tissue growth for tissue engineering image courtesy of MEMS Clearinghouse

13. Health Care Applications of Nanotechnology WEC Nanotech Rountable NY | March 11, 2005 | Y. Yazdi, Ph.D.12 Summary: An Industry View of ‘Nanotechnology’  not a platform or a specific field of technology, rather, the natural progression of all fields of science and technology in understanding and manipulating matter on a smaller and smaller scale.  not just smaller -- enables development of new materials and systems with novel properties, features  expected to have a substantial impact on almost every field of science, industry, health care  today, most activity still in the realm of science not tech  manage like other technologies: surveillance, relationships, organic entry, avoid hype, focus on real impact on health care

14. Health Care Applications of Nanotechnology WEC Nanotech Rountable NY | March 11, 2005 | Y. Yazdi, Ph.D.13 Nanotechnology: a test of industry’s ability to manage new science "Wherever this field leads, it is likely to follow the well-known pathway of incredible results leading to unrealistic expectations followed by sobering complications and disappointments - and ultimately, cautious optimism." - Drs Roger Latham and Peter Oettgen, Harvard Medical School

15. Health Care Applications of Nanotechnology WEC Nanotech Rountable NY | March 11, 2005 | Y. Yazdi, Ph.D.14 a few thoughts on environmental issues…  Nanotech is not fundamentally new, rather a stage in a continuum of human control over matter  Modern ‘Nanotech’ can reduce risk by enabling us to measure, model, understand and control what people and nature have been doing all along, and better assess the impact of new products NYT, February 22, 2005 “Tiny Is Beautiful: Translating 'Nano' Into Practical”, KENNETH CHANG

16. Health Care Applications of Nanotechnology WEC Nanotech Rountable NY | March 11, 2005 | Y. Yazdi, Ph.D.15 Our Credo …We must maintain in good order the property we are privileged to use, protecting the environment and natural resources… General Robert Wood Johnson, 1943