1. Batterjee Medical College

2. Dr. Manal El Said Chlamydiae Head of Medical Microbiology Department

3. Batterjee Medical College 1-Chlamydia trachomatis Diseases Characteristics Nongonococcal urethritis Cervicitis Inclusion conjunctivitis Lymphogranuloma venereum Trachoma. Pneumonia in infants. Obligate intracellular parasites. Not seen on Gram-stained smear. Exists as inactive elementary body extracellularly & metabolically active, dividing reticulate body intracellularly.

4. Batterjee Medical College 1-Chlamydia trachomatis

5. Batterjee Medical College Habitat and Transmission 1-Chlamydia trachomatis Pathogenesis Habitat is human genital tract & eyes. Transmission is by sexual contact & during passage of neonate through birth canal. Transmission in trachoma is by hand-to-eye contact. No toxins or virulence factors known.

6. Batterjee Medical College 1-Chlamydia trachomatis Pathogenesis

7. Batterjee Medical College Laboratory Diagnosis 1-Chlamydia trachomatis Cytoplasmic inclusions on Giemsa-stained or fluorescent antibody–stained smear. Glycogen-filled cytoplasmic inclusions can be visualized with iodine. Organism grows in cell culture & embryonated eggs. PCR-based assay & ELISA using patient's urine

8. Batterjee Medical College 1-Chlamydia trachomatis Laboratory Diagnosis

9. Batterjee Medical College Treatment 1-Chlamydia trachomatis Tetracycline (such as doxycycline) Macrolide (such as azithromycin). Erythromycin effective in infected mother to prevent neonatal disease. No vaccine is available. Prevention

10. Batterjee Medical College 2-Chlamydia pneumoniae Diseases Characteristics Atypical pneumonia. Same as C. trachomatis. Habitat is human respiratory tract. Transmission is by respiratory aerosol. Habitat and Transmission

11. Batterjee Medical College 2-Chlamydia pneumoniae

12. Batterjee Medical College Pathogenesis 2-Chlamydia pneumoniae No toxins or virulence factors known. Serologic tests for antibody in patient's serum. Laboratory Diagnosis Tetracycline, such as doxycycline. Treatment Prevention No vaccine or drug is available.

13. Batterjee Medical College 3-Chlamydia psittaci Diseases Psittacosis. Symptoms range from inapparent illness to systemic illness with severe pneumonia. It presents as atypical pneumonia. In 1 st week symptoms are: prostrating high fevers, arthralgias, diarrhea, conjunctivitis, epistaxis & leukopenia. Rose spots (Horder's spotscan) appear. Splenomegaly is frequent toward end of 1 st week.

14. Batterjee Medical College Characteristics 3-Chlamydia psittaci Same as C. trachomatis. Habitat and Transmission Habitat is birds (psittacine & others). Transmission is via aerosol of dried bird feces.

15. Batterjee Medical College 3-Chlamydia psittaci Pathogenesis No toxins or virulence factors known. Laboratory Diagnosis Diagnosis made by testing for antibodies in patient's serum. Cytoplasmic inclusion seen by Giemsa or fluorescent antibody staining. Organism can be isolated from sputum (rarely done).

16. Batterjee Medical College 3-Chlamydia psittaci Treatment Prevention Tetracycline. No vaccine or drug is available.