1. Plan for the coming years VELUX FONDEN - D A N I S H A G I N G R E S E A R C H C E N T E R - www.sdu.dk/darc Why do we age so differently?

2. Danish Aging Research Center

4. Current Ph.D. projects  Continue isolation of lymphocytes and analysis of repair capacities in twin samples  Initiate isolation of lymphocytes and analysis of mitochondrial functions in samples from fatigue and non- fatigue individuals  Confirm preliminary data on nuclear and mitochondrial carbonylation in premature aging syndromes  Continue study on regulation of synaptic mitochondrial DNA repair activity  Establish methods suitable for telomere length measurement in twin and other cohort samples  Initiate telomere length measurements in samples from twins and extreme social class individuals

5. Potential development - when correlations have been identified  Mechanisms/factors regulating DNA repair activity?  Posttranslational modifications of DNA repair proteins  Correlation with specific polymorphisms in DNA repair proteins  Effect on localization  Effect on proein-protein interactions  Effect on specific activity  Effect on stability  Effect of environmental factors on specific DNA repair activities

6. Potential development - when correlations have been identified  Mechanisms/factors regulating mitochondrial function?  Effect of specific (environmental) factors on specific function  Correlation between telomere length and DNA repair capacity?  Identification of potential mechanisms