1. Syphilis  制作人： 陈永 冯斌 时迎斌 张伟强 孙景福 陈娜 徐平 周强 于晓宁 叶茜 主讲人：叶茜

3. Syphilis TThere are more than 70,000 new cases of syphilis （梅毒） each year. SSyphilis, chronic and slowly progressive, is the third most common sexually transmitted disease.

4. Spirochetes  Gram negative bacteria  long, thin, helical and motile  Axial filaments - (a form of flagella) - are the locomotory organelles found between the peptidoglycan layer and outer membrane and running parallel to them

5. T.Pallidum

7. Mechanism The antibodies result from tissue injury, with autoimmunity developing to self components.

8. Transmission  T. pallidum is generally transmitted by genital/genital contact.  Transmission in utero or during birth can also occur. It can also be transmitted through blood transfusion.

9. Congenital syphilis

10. Blood Transfusion TThe main manifestation FFever RRobeola SSymptoms like secondary stage of syphilis

11. Pathogenic process PPrimary syphilis SSecondary syphilis TTertiary syphilis

12. Primary syphilis  After initial infection hard chancre present.  Mainly seen in outer genital organ.  Last for 4 to 8 weeks.

13. Secondary syphilis  The organisms has penetrate and systemically spread during this time period.  The patient has flu-like symptoms with secondary lesion particularly affecting the skin(2-10 weeks later)  Mainly in trunk and limbs.

14. Secondary Syphilis

16. Common features of primary and secondary syphilis IIn these two stages large numbers of T. Pallidum often present. SStrong infection, weak damage. SSelf-limited

17. Tertiary syphilis  The final stage is tertiary syphilis ( after several years later).  As the disease progresses immunity controls the bacterial replication and few organisms are seen.  Main manifestation are chronic granuloma and tissue necrosis.

18. Tertiary Syphilis

20. Diagnosis(1)  The organisms are often present in sufficient numbers in exudates detected by dark field microscopy.  The actively motile organisms appears brightly lit against the dark backdrop.  The FTA-ABS （ 荧光密螺旋体抗体吸收 试验 ) is often used.

21. Diagnosis(2) 3.VDRL and RPR are also widely used. 1.Serological methods are usually used to detect syphilis. 2. Screening methods are based on detecting serum antibodies to cardiolipin in patients (including VDRL test).

22. Therapy  No vaccine exists, but antibiotic therapy (usually penicillin G) is usually highly effective.

23.  That is all.  Thank you!