1. The company of specialists.

2. 2Copyright © 2009 i3 | CONFIDENTIAL Economic Analyses of Niaspan ® in Latin America f or Abbott Laboratories Project Initiation Meeting Rio de Janeiro, Brazil 9 September 2009

3. 3Copyright © 2009 i3 | CONFIDENTIAL Agenda  Introductions  Project Overview & Abbott Expectations  i3 Innovus Review of Project Scope  Role of Latin American Research Consortium  Overview of Niaspan ® Global Models  Project Roles  Project Deliverables & Timelines  Final Questions

4. 4Copyright © 2009 i3 | CONFIDENTIAL Introductions: Abbott Abbott Global HEOR  Bob Simko  *Silky Webb Abbott Latin America  Diego Cortina; Abbott Mexico  Gena Laranjeira; Abbott Brazil  Paulo Vega Mateus; Abbott Colombia * Abbott point-of-contact

5. 5Copyright © 2009 i3 | CONFIDENTIAL Introductions: i3 Innovus Project Team  David Thompson; Project Director  *Joanna Campbell; Senior Manager  Hemangi Parekh; Research Analyst  Kevin Leahy; Research Associate * i3 Innovus point-of-contact

6. 6Copyright © 2009 i3 | CONFIDENTIAL Introductions: i3 Innovus Latin American Research Partners AxiaBio (Brazil)  Gabriella Tannus de Araujo; Health Economics Director Guia Mark (Mexico)  Leon Zapata; Director General HEORT (Colombia)  Alejandro Bryon; Project Manager  Ximena Burbano; Research Director IECS (Argentina)  Federico Augustovski; Director, Health Economic Evaluation

7. 7Copyright © 2009 i3 | CONFIDENTIAL Project Overview & Abbott Expectations Silky Webb; Abbott

8. 8Copyright © 2009 i3 | CONFIDENTIAL i3 Innovus Review of Project Scope: Study Objectives The specific objectives for this project are to:  Evaluate current Abbott global economic models of Niaspan® for suitability of adaptation to Latin America –Identify local-area data requirements  Identify, evaluate & collect local secondary data in six countries –Argentina, Brazil, Colombia, Mexico, Peru & Venezuela  Propose appropriate methods of supplementary primary data collection, where necessary

9. 9Copyright © 2009 i3 | CONFIDENTIAL i3 Innovus Review of Project Scope: Develop Research Plan i3 Innovus to work with Abbott to develop a written research plan for the project  Specify project objectives  Describe specific research tasks –Search strategy –Data evaluation guidelines –Data analysis plan for Brazil & Colombia –Criteria for assessing primary data collection strategies  Specify content & format of project deliverables –Data abstraction template –Study report outline

10. 10Copyright © 2009 i3 | CONFIDENTIAL i3 Innovus Review of Project Scope: Evaluation of Niaspan® Global Economic Models Conduct a thorough review of existing global Niaspan ® models  Inventory the data requirements for each model –Assess need for Latin American data inputs, target search for appropriate local-area data  Evaluate model flexibility in incorporating new treatment comparators –Treatments for hypercholesterolemia/mixed dyslipidemia –Treatments for disease-related complications  Document identified deficiencies and collaborate with Abbott to develop recommendations

11. 11Copyright © 2009 i3 | CONFIDENTIAL i3 Innovus Review of Project Scope: Identification, Evaluation & Collection of Local-Area Data Work with consortium of research partners in the Latin American region to  Identify sources for required local-area estimates: –disease epidemiology (prevalence & incidence) –clinical endpoints in model (e.g. plasma cholesterol, HDL-C, LDL-C, triglycerides) –treatment patterns –costs of treatments for disease & disease-related complications  Evaluate quality of data sources  Abstract readily acquired data into excel spreadsheets –Where available, collect separate data for public & private payers

12. 12Copyright © 2009 i3 | CONFIDENTIAL i3 Innovus Review of Project Scope: Identification, Evaluation & Collection of Local Data (cont’d)  Data searches will be conducted using English-, Portuguese-, and Spanish-language sources: –General: PubMed and Google Scholar –Region-specific: LILACS, SciELO, Compumedicina –PAHO publications  Review of publications by national statistical agencies –Epidemiology –Healthcare resource use –Healthcare costs

13. 13Copyright © 2009 i3 | CONFIDENTIAL i3 Innovus Review of Project Scope: Identification, Evaluation & Collection of Local Data (cont’d)  Gaps likely in local secondary data sources –Especially healthcare utilization (& costs)  High-quality electronic data resources in Brazil and Colombia already identified –Data analysis plans to be reviewed by Abbott prior to implementation  Document remaining gaps in secondary sources –Evaluate alternative methods of supplementary primary data collection for likely validity, cost, ease of acquisition Advisory boards Analysis of local hospital or payer databases Chart reviews Surveys of local providers and/or prayer representatives

14. 14Copyright © 2009 i3 | CONFIDENTIAL i3 Innovus Review of Project Scope: Prepare Study Report  i3 Innovus will prepare a study report describing in detail the study’s objectives, methods, findings, and implications  Study report to center on: –Model evaluations –Results of search for local data –Recommendations for supplemental primary data collection

15. 15Copyright © 2009 i3 | CONFIDENTIAL i3 Innovus Latin American Research Partners Gabriella Tannus de Araujo; AxiaBio Ximena Burbano; HEORT Federico Augustovski; IECS Leon Zapata; Guia Mark

16. 16Copyright © 2009 i3 | CONFIDENTIAL Overview of Niaspan ® Global Models Silky Webb; Abbott

17. 17Copyright © 2009 i3 | CONFIDENTIAL Project Roles & Responsibilities:  Abbott Project Lead –Silky Webb; Tel: 847.938.0200 email: silky.webb@abbott.comsilky.webb@abbott.com  i3 Innovus Project Manager –Joanna Campbell; Tel: 781.518.4017 email: joanna.campbell@i3innovus.comjoanna.campbell@i3innovus.com  Abbott – i3 Innovus Business Development Liaison –Kevin Kelly Tel: 317.564.2913 email: kevin.kelly@i3innovus.comkevin.kelly@i3innovus.com

18. 18Copyright © 2009 i3 | CONFIDENTIAL Project Deliverables  Agenda & meeting summary for initial kick-off meeting  Research plan: draft & final  Study report w/ data appendices: draft & final

19. 19Copyright © 2009 i3 | CONFIDENTIAL Project Timelines *Dates & times of update calls to be confirmed

20. 20Copyright © 2009 i3 | CONFIDENTIAL Additional Questions

21. 21Copyright © 2009 i3 | CONFIDENTIAL The company of specialists.