1. Boaz Blankrot Leon Karabchevsky Adi Hanuka June 18 th, 2013 Acknowledgments: Prof. Levi Schächter, Dr. Daniel Briscoe, Mr. Eli Shoshan, Mr. Mony Orbach, Mr. Alex Kinko, Mr. Stanislav Shapira

2. Goal How does it work? Eyelid Sensor Device (ESD) Eyelid Pro Summary & Liveshow Summary & Live show1 2 3 4 5

3. Damage to muscles or nerves Topical and systemic medication Degenerative neurologic diseases Systemic diseases Eye disease (Ptosis, Cataract, Glaucoma) Observation-based diagnosis can be time-consuming, and inaccurate due to the unnatural conditions in the doctor’s office. Goal 1 Many medical conditions can be diagnosed by observing the patients’ eyelid movement, such as:

4. Eyelid Pro Eyelid Sensor Device (ESD) Patient Doctor Creating a complete solution which will allow: Recording the patients’ eyelid movement in a more “relaxed environment” Analysis and diagnosis of the results by the doctor Creation of a wide database of movement patterns and medical conditions for research purposes Our solution: Eyelid Sensor Device (ESD) & Eyelid Pro Goal 2

5. Goal How does it work? Eyelid Sensor Device Eyelid Pro Summary & Liveshow Summary & Live show1 2 3 4 5

6. A tiny magnet is attached to the eyelid 4 sensors measure the varying magnetic field due to eyelid motion Data is processed and stored on a micro-SD card, for later analysis by Eyelid Pro Eyelid Pro Alternatively, data can be sent directly via USB ESD How? 3

7. 4 Sample & Processing Magnetic field Voltage Calibration How?

8. 5 Method that retrieves the motion’s characteristics from the voltage measurements Data Base Presentation & Analysis How?

9. Goal How does it work? Eyelid Sensor Device Eyelid Pro Summary & Liveshow Summary & Live show1 2 3 4 5

10. ESD 6

11. User-friendly operation On/Off/Sleep mode switch Start/Stop recording switch Device is ‘foolproof’ – operates only according to pre-defined workflow Notification system Device’s state is indicated by 2 tri-color LEDs and buzzer Signal processing The device samples the eyelid motion, processes it and stores it ~40 times faster than a blink of an eye USB communication Communicates with the PC using a simple USB port, enabling high-speed and plug-and-play functionality ESD 7

12. Operating modes Real-time –patient’s eyelid motion is sent directly to the doctor’s screen Offline –data is stored on internal micro-SD card Portability Powered by a lightweight rechargeable battery Automatically recharges through USB port Storage ESD 8 Diagnosing illnesses necessitates at least 10 minutes of observation, requiring a high capacity solution A micro-SD card is used (up to 2GB, or 10,000 minutes of storage) When connected, device is recognized as a disk-on-key, enabling: robustness, speed, ease-of-use & future development

13. Goal How does it work? Eyelid Sensor Device Eyelid Pro Summary & Liveshow Summary & Live show1 2 3 4 5

14. A software tool that provides the doctor with a wide array of abilities, including: receiving, analyzing & storing the recorded eyelid motion. Doctor’s interface with the patient data User-friendly Advanced analysis tools Eyelid Pro 9

15. 1. Eyelid pattern analyzer Annotation support Session remarks Advanced toolbar Full screen view Cursor positioning Image export Eyelid Pro 10

16. 2. Eyelid pattern comparison tool Visually compare data between different sessions & even between different patients Ability to adjust all axes simultaneously or separately Patient #1 Patient #2 Eyelid Pro 11

17. 3. Real-Time data acquisition Includes all pattern analyzer capabilities Adjustable sample viewing window Ability to store the session 4. Results database Easily updatable patient’s record, including medical conditions & medication Ability to ignore/un-ignore recorded eyelid motion data Eyelid Pro 12

18. 5. Simultaneous multiple devices Automatic device detection & user selection option 6. Usability Tool-tips, user manual & fully documented design Easy to deploy – just press “install”… Eyelid Pro 12

19. Goal How does it work? Eyelid Sensor Device Eyelid Pro Summary & Liveshow Summary & Live show1 2 3 4 5

20. HaEmek Medical Center, Afula, Israel The system was presented to the Ophthalmology department, headed by Dr. Daniel Briscoe. Conferences The system’s medical and technological principles were presented at: ISVER 2013 – 33 rd Meeting of the Israeli Society of Vision and Eye Research. OOG 2013 – 43 rd Spring meeting of the European Ophthalmic Oncology Group. Clinical research ESD will be used for clinical trials in the nearby future. Summary 13

21. Automatic diagnostics Automatically diagnose based on the eyelid pattern and medical database Multidisciplinary research The system provides a platform for: Psychological studies Analyzing reaction time to different stimuli Communication for paralyzed people Balance Summary 14

23. ?@*#$?

24. Thank you!